ID LONF3_MOUSE Reviewed; 753 AA.
AC Q9D4H7;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 24-JAN-2024, entry version 155.
DE RecName: Full=LON peptidase N-terminal domain and RING finger protein 3;
DE AltName: Full=RING finger protein 127;
GN Name=Lonrf3; Synonyms=Rnf127;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
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DR EMBL; AK016522; BAB30284.1; -; mRNA.
DR EMBL; AL450395; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC120688; AAI20689.1; -; mRNA.
DR EMBL; BC120690; AAI20691.1; -; mRNA.
DR CCDS; CCDS30059.1; -.
DR RefSeq; NP_083170.1; NM_028894.1.
DR AlphaFoldDB; Q9D4H7; -.
DR SMR; Q9D4H7; -.
DR BioGRID; 216694; 2.
DR STRING; 10090.ENSMUSP00000016383; -.
DR PhosphoSitePlus; Q9D4H7; -.
DR SwissPalm; Q9D4H7; -.
DR MaxQB; Q9D4H7; -.
DR PaxDb; 10090-ENSMUSP00000016383; -.
DR ProteomicsDB; 292350; -.
DR Antibodypedia; 29740; 161 antibodies from 22 providers.
DR DNASU; 74365; -.
DR Ensembl; ENSMUST00000016383.10; ENSMUSP00000016383.4; ENSMUSG00000016239.12.
DR GeneID; 74365; -.
DR KEGG; mmu:74365; -.
DR UCSC; uc009sxm.1; mouse.
DR AGR; MGI:1921615; -.
DR CTD; 79836; -.
DR MGI; MGI:1921615; Lonrf3.
DR VEuPathDB; HostDB:ENSMUSG00000016239; -.
DR eggNOG; KOG1124; Eukaryota.
DR eggNOG; KOG4159; Eukaryota.
DR GeneTree; ENSGT00440000033329; -.
DR HOGENOM; CLU_013989_1_2_1; -.
DR InParanoid; Q9D4H7; -.
DR OMA; RLMPHWS; -.
DR OrthoDB; 3088759at2759; -.
DR PhylomeDB; Q9D4H7; -.
DR TreeFam; TF327043; -.
DR BioGRID-ORCS; 74365; 3 hits in 77 CRISPR screens.
DR ChiTaRS; Lonrf3; mouse.
DR PRO; PR:Q9D4H7; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q9D4H7; Protein.
DR Bgee; ENSMUSG00000016239; Expressed in cleaving embryo and 99 other cell types or tissues.
DR ExpressionAtlas; Q9D4H7; baseline and differential.
DR Genevisible; Q9D4H7; MM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR CDD; cd16513; RING-HC_LONFs_rpt1; 1.
DR CDD; cd16514; RING-HC_LONFs_rpt2; 1.
DR Gene3D; 2.30.130.40; LON domain-like; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR003111; Lon_prtase_N.
DR InterPro; IPR046336; Lon_prtase_N_sf.
DR InterPro; IPR015947; PUA-like_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR23327:SF41; LON PEPTIDASE N-TERMINAL DOMAIN AND RING FINGER PROTEIN 3; 1.
DR PANTHER; PTHR23327; RING FINGER PROTEIN 127; 1.
DR Pfam; PF02190; LON_substr_bdg; 1.
DR Pfam; PF00097; zf-C3HC4; 1.
DR Pfam; PF13923; zf-C3HC4_2; 1.
DR SMART; SM00464; LON; 1.
DR SMART; SM00184; RING; 2.
DR SMART; SM00028; TPR; 4.
DR SUPFAM; SSF88697; PUA domain-like; 1.
DR SUPFAM; SSF57850; RING/U-box; 2.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51787; LON_N; 1.
DR PROSITE; PS50005; TPR; 3.
DR PROSITE; PS50293; TPR_REGION; 1.
DR PROSITE; PS00518; ZF_RING_1; 2.
DR PROSITE; PS50089; ZF_RING_2; 2.
PE 2: Evidence at transcript level;
KW Metal-binding; Reference proteome; Repeat; TPR repeat; Zinc; Zinc-finger.
FT CHAIN 1..753
FT /note="LON peptidase N-terminal domain and RING finger
FT protein 3"
FT /id="PRO_0000277673"
FT REPEAT 72..105
FT /note="TPR 1"
FT REPEAT 244..277
FT /note="TPR 2"
FT REPEAT 279..311
FT /note="TPR 3"
FT REPEAT 313..345
FT /note="TPR 4"
FT DOMAIN 540..749
FT /note="Lon N-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01123"
FT ZN_FING 159..197
FT /note="RING-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT ZN_FING 461..499
FT /note="RING-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT REGION 17..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 351..450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 368..384
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 385..431
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 753 AA; 83656 MW; B516FD1D555C0FB7 CRC64;
MDSLQTAQMV SLSAELGSNN LELAEPEEPG TSAAAGQSAA HPEEVTPEGS QALGAQEPEQ
SLPLAVPTPL ECKVLLTQAD ALASEGHLRE ALEVYRQLSE RQQLVAEQLE QLVRCLADSV
PQEELASDSS GTSSCCAAAL KEAGEAAAVA PEVWDGFKCK KCHGFLSDPV SLWCGHTFCK
LCLERGRAAD RRCALCGVKL SALMAASGRA RGPRRAGQPA PLQLRVNVVL SGLLGKLFPG
PARASQLRHE GNRLFREHQV EAALLKYNEA VRLAPNDHLL YSNRSQIYFT LESHEDALHD
AEIACKLRPM GFKAHFRKAQ ALATLGKVKE ALKEFLYCVS LDGKNKSARS EAQRENLELP
HCSNQEGAAA AEESSSLANS AQGKVSSKED RKKDQEGEDR DAASVRTGKC QEKKRNRCQI
ETQEDTELPN KVSKQDFPAE QGAKPDLSNP LGSFDASDLE CSLCMRLFYE PVTTPCGHTF
CLKCLERCLD HNAKCPLCKD VLLQCLPSRK YSKNVILEEL IATFLPEEFK ERKRLYEEEM
EELSNLNKNV PIFVCTMAYP TVPCPLHIFE PCYRLMIRRC IETGTRQFGM CLGDPVKGFV
EYGCILEIRN VQFFSDGRSV VDSIGKRRFK VLHQGQRDGY NTADIEYIED QKVQGDDCAE
LMGLHNCVYE QASSWFHSLK ASLKNRILNH FGPMPEKDED PQVNPNGPAW CWWTLAVLPL
ESRAQLPFLA MRSLKDRLNG IRRILAFISR NQN
//
