ID LSRB_ECOSM Reviewed; 340 AA.
AC B1LF99;
DT 14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Autoinducer 2-binding protein LsrB;
DE Short=AI-2-binding protein LsrB;
DE Flags: Precursor;
GN Name=lsrB; OrderedLocusNames=EcSMS35_1656;
OS Escherichia coli (strain SMS-3-5 / SECEC).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=439855;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SMS-3-5 / SECEC;
RX PubMed=18708504; DOI=10.1128/jb.00661-08;
RA Fricke W.F., Wright M.S., Lindell A.H., Harkins D.M., Baker-Austin C.,
RA Ravel J., Stepanauskas R.;
RT "Insights into the environmental resistance gene pool from the genome
RT sequence of the multidrug-resistant environmental isolate Escherichia coli
RT SMS-3-5.";
RL J. Bacteriol. 190:6779-6794(2008).
CC -!- FUNCTION: Part of the ABC transporter complex LsrABCD involved in
CC autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and
CC LsrD permeases (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (LsrA),
CC two transmembrane proteins (LsrC and LsrD) and a solute-binding protein
CC (LsrB). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the bacterial solute-binding protein 2 family.
CC {ECO:0000305}.
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DR EMBL; CP000970; ACB19798.1; -; Genomic_DNA.
DR RefSeq; WP_000172466.1; NC_010498.1.
DR AlphaFoldDB; B1LF99; -.
DR SMR; B1LF99; -.
DR KEGG; ecm:EcSMS35_1656; -.
DR HOGENOM; CLU_037628_3_0_6; -.
DR Proteomes; UP000007011; Chromosome.
DR GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:UniProt.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProt.
DR CDD; cd20003; PBP1_LsrB_Quorum_Sensing; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR InterPro; IPR030159; LsrB.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR025997; SBP_2_dom.
DR PANTHER; PTHR30036; D-XYLOSE-BINDING PERIPLASMIC PROTEIN; 1.
DR PANTHER; PTHR30036:SF1; D-XYLOSE-BINDING PERIPLASMIC PROTEIN; 1.
DR Pfam; PF13407; Peripla_BP_4; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
PE 3: Inferred from homology;
KW Periplasm; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..340
FT /note="Autoinducer 2-binding protein LsrB"
FT /id="PRO_0000351318"
SQ SEQUENCE 340 AA; 36685 MW; D11AFACEC79171CE CRC64;
MTLHRFKKIA LLSALGIAAI SMNVQAAERI AFIPKLVGVG FFTSGGNGAQ QAGKELGVDV
TYDGPTEPSV SGQVQLINNF VNQGYNAIIV SAVSPDGLCP ALKRAMQRGV RVLTWDSDTK
PECRSYYINQ GTPAQLGGML VDMAARQVNK DKAKVAFFYS SPTVTDQNQW VKEAKAKIAK
EHPGWEIVTT QFGYNDATKS LQTAEGILKA YSDLDAIIAP DANALPAAAQ AAENLKNDKV
AIVGFSTPNV MRPYVERGTV KEFGLWDVVQ QGKISVYVAD ALLKKGSMKT GDKLDIQGVG
QVEVSPNSVQ GYDYEADGNG IVLLPERVIF NKENIGKYDF
//
