ID LSRR_ECO24 Reviewed; 317 AA.
AC A7ZLX0;
DT 14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE RecName: Full=Transcriptional regulator LsrR;
GN Name=lsrR; OrderedLocusNames=EcE24377A_1713;
OS Escherichia coli O139:H28 (strain E24377A / ETEC).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=331111;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E24377A / ETEC;
RX PubMed=18676672; DOI=10.1128/jb.00619-08;
RA Rasko D.A., Rosovitz M.J., Myers G.S.A., Mongodin E.F., Fricke W.F.,
RA Gajer P., Crabtree J., Sebaihia M., Thomson N.R., Chaudhuri R.,
RA Henderson I.R., Sperandio V., Ravel J.;
RT "The pangenome structure of Escherichia coli: comparative genomic analysis
RT of E. coli commensal and pathogenic isolates.";
RL J. Bacteriol. 190:6881-6893(2008).
CC -!- FUNCTION: Regulates transcription of many different genes. In the
CC absence of autoinducer 2 (AI-2), represses transcription of the lsr
CC operon and its own transcription. In the presence of AI-2, LsrR is
CC inactivated by binding phospho-AI-2, leading to the transcription of
CC the lsr genes (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SorC transcriptional regulatory family.
CC {ECO:0000305}.
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DR EMBL; CP000800; ABV20760.1; -; Genomic_DNA.
DR RefSeq; WP_000154340.1; NC_009801.1.
DR AlphaFoldDB; A7ZLX0; -.
DR SMR; A7ZLX0; -.
DR GeneID; 75202160; -.
DR KEGG; ecw:EcE24377A_1713; -.
DR HOGENOM; CLU_054506_0_1_6; -.
DR Proteomes; UP000001122; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1360; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR InterPro; IPR007324; Sugar-bd_dom_put.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR34294:SF12; TRANSCRIPTIONAL REGULATOR LSRR; 1.
DR PANTHER; PTHR34294; TRANSCRIPTIONAL REGULATOR-RELATED; 1.
DR Pfam; PF04198; Sugar-bind; 1.
DR SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 1.
PE 3: Inferred from homology;
KW Activator; Cytoplasm; DNA-binding; Reference proteome; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..317
FT /note="Transcriptional regulator LsrR"
FT /id="PRO_0000351614"
FT DNA_BIND 33..52
FT /note="H-T-H motif"
FT /evidence="ECO:0000255"
SQ SEQUENCE 317 AA; 33814 MW; B60AA1F47B7DA3B4 CRC64;
MTINDSAISE QGMCEEEQVA RIAWFYYHDG LTQSEISDRL GLTRLKVSRL LEKGHQSGII
RVQINSRFEG CLEYETQLRR QFSLQHVRVI PGLADADVGG RLGIGAAHML MSLLQPQQML
AIGFGEATMN TLQRLSGFIS SQQIRLVTLS GGVGSYMTGI GQLNAACSVN IIPAPLRASS
ADIARTLKNE NCVKDVLLAA QAADVAIVGI GAVSQQDDAT IIRSGYISQG EQLMIGRKGA
VGDILGYFFD AKGDVVTDIK IHNELIGLPL SSLKTIPVRV GVAGGENKAE AIAAAMKGGY
INALVTDQDT AAAILRS
//
