ID LVSG_DICDI Reviewed; 2179 AA.
AC Q55FJ0;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 115.
DE RecName: Full=Probable inactive serine/threonine-protein kinase lvsG;
DE AltName: Full=Large volume sphere mutant lvsA-like protein G;
GN Name=lvsG; ORFNames=DDB_G0268088;
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- DOMAIN: The protein kinase domain is predicted to be catalytically
CC inactive.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC kinase family. {ECO:0000305}.
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DR EMBL; AAFI02000003; EAL73497.1; -; Genomic_DNA.
DR RefSeq; XP_647543.1; XM_642451.1.
DR AlphaFoldDB; Q55FJ0; -.
DR SMR; Q55FJ0; -.
DR PaxDb; 44689-DDB0231499; -.
DR EnsemblProtists; EAL73497; EAL73497; DDB_G0268088.
DR GeneID; 8616350; -.
DR KEGG; ddi:DDB_G0268088; -.
DR dictyBase; DDB_G0268088; lvsG.
DR eggNOG; KOG1786; Eukaryota.
DR HOGENOM; CLU_231449_0_0_1; -.
DR InParanoid; Q55FJ0; -.
DR OMA; NKMESCA; -.
DR PRO; PR:Q55FJ0; -.
DR Proteomes; UP000002195; Chromosome 1.
DR CDD; cd06071; Beach; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR46866; GH12955P; 1.
DR PANTHER; PTHR46866:SF1; GH12955P; 1.
DR Pfam; PF02138; Beach; 2.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 2.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Coiled coil; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..2179
FT /note="Probable inactive serine/threonine-protein kinase
FT lvsG"
FT /id="PRO_0000362022"
FT REPEAT 216..256
FT /note="WD 1"
FT DOMAIN 463..801
FT /note="BEACH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00026"
FT DOMAIN 1064..1400
FT /note="Protein kinase"
FT REPEAT 1864..1903
FT /note="WD 2"
FT REPEAT 1906..1942
FT /note="WD 3"
FT REPEAT 1945..1983
FT /note="WD 4"
FT REPEAT 2007..2048
FT /note="WD 5"
FT REPEAT 2052..2089
FT /note="WD 6"
FT REPEAT 2149..2179
FT /note="WD 7"
FT REGION 100..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 281..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 523..556
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 589..621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 778..801
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 844..959
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1033..1055
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1079..1153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1339..1362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1785..1807
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1021..1049
FT /evidence="ECO:0000255"
FT COMPBIAS 142..167
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 533..556
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 599..616
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 781..801
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 854..947
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2179 AA; 245159 MW; 969F8D73DE24F538 CRC64;
MGQTVSKEEI KEEIEKQLNI CFLSLDQEDI HSKNSISFNL STVSAHKGSI DFIFNKTSNN
NSSLIGSNGF VNISNNNIID DLIKDKSTSI LLQYANKHND HDLNKNKNNN NNSEENNNNS
GEGDEDNTGE KAPPPAPSSP LSPSSSSSTS TTTTPLSTSI SLNDLNSMPR KRTTIKYKQG
SFEASSYDGD EISIQVVKKN WINNSNDNNS QQRPRLYERS LKTSQQQQQQ QQQQFKFQPN
ETLSLWEYFD EINSPPMLYN IDQNNLNFTN NYIVQEKLNS LDNKDDDDNN NNNNNSNSQS
FTFNKEFIKS VLQSFSTYIS SLPNSIHFTD TNIPPSIDYT SPNVLKLHPN LLPIIEIIYN
DIDNNDNDND DDDDKNNNNL NDKIFIIYKK YNYTLDGLLR YSLQYLQRNQ KITTFMIYQL
IQLFSFLHQR EIVHGDLQPS NIHLNNQMWL GLEGFSFPST PLYHQPLENQ FESSMNKWIN
GELSNFNYLM ILNHLAHRHI GDPMNHPVLP WVIDFTTSPI NIDNDNDSRD DVDNSSSSNN
NNNNNNEDQS GKTVGWRDLT KTKYRLNKGD EQLDFQFFNT GNSTTLGDDS MGGGIGSIGS
TGGITNSSNN GGGGGSGNSG KAHHISDILS ELTYYSYLAR RTSVPLLRRF VRTNYEPNEY
PATMERLYRW TPDECIPEFF TDSTIFKSIH SDMPDLQLPD WVPNQSTQEF IKIHMNALES
DHVSKQLHSW IDLTFGYLLS GEEAIKAKNL ALMDTTIPRN NGIVQLFNHP HPKKKYLKSL
KYQRQQQTQQ HQQQTQQQPQ FDTEFTIKFN ESSFRYENQN INHNSTFLPN TTINSILNNL
SNVNNHHHHH SHNSNIPNTV SSRSDSFGSN SSSSAPGNSN SNILLSPSMS SSMGSLNSAT
SPSSQSQSSH QQTSSTPTSQ TQRSFSIINN NNSSSSSNSG VNNKPRTSSG KKEGENKPSL
AKFLPSLFTQ AIKIEKEDNS IVSSSPTNTP VQIDLLSSVN SNYIGYGSSI GNSSMQHQLY
LQQQLQQQQQ QQAQQQQSQQ QSQQQQANSP NSKQLHLIHS KSEESMIKKY SNGLFSSMGI
SKSTTNAPTT NNTTTNSNMG DSIGNNITSP PSPTSLKDSS SIQQQQQQQQ QQQQNSESTR
PITPPNVSNS TTDLSSIYTN QEHIIEPLPA ELELELYEYE LLNKDVTGIN ANIIYSSSPT
NVSTTTNTTT STTQPYIIYN NNTTQNNVAS YHSQQKKPNV FIESLLNCEL NNEFGHNFEN
LLPIYRPLEF NDNNSGSSEL SIDNEKNKGL IKIFSNNKEQ SNLEILKSND MFALGCIIAE
LYQGYPLFTS KGLENHFLNH SNSSNNNNNN NNNNNNNNKN GSFMITSNLP NNVKEIVDKL
IQPNPMERSE VNELLSSSLF PNYFKQMYHF LVHYHSLNTP EERLTFTLAN IGIVTSLPNE
SIDLILPFIL ELFYDSKTMV SALIDLLDPL SQRLGIHLST SYLLPCLIAL YQRHDDHLLQ
CHLIQIPMID MIVSRFGRDV YIHHILPFLL DSVKTNPKDN PNHEMLTTAL IKISKVLGIP
LTIRHMMYPL LVALTKPRLQ HLNEPLVAIA SSLGENVIVK FYFPSIFILI QKHSSKASRS
ESIPCTLLSL LQELILLVKP GLVLRSLLKE STQLASLLLN PSNTSLLLPL AETLLRISGR
IGVNHTKNYI LKYVQQFFSN YSDLYDYSGD NSYAKIGGDS ETTKQLRSIY SPEMTYYLYY
KLARIIGFEV MRAEISDNSL IEHIMRIYIK ENNIKTTNST ITTTTTTTTT TTTTTTTNNN
NENPNSLNFI PPYVSDDGLY DIIEETLDQK ISSTYLLDDY QDYDDLICDK TFTLQGNIVA
QYKEHNASIK SLAVSPSEER FISGSKDNLV KIWSLDSTKS LTTYNQHMHT AHTVHFVSSL
VASCDITSIQ VWDPESKIKV NVFYEPTGSF SCFEPISSKY LIASTCESTL SFYDLSMGSL
THEWSLAYQT GQAIRCIATS NDHLIGSNSN QFSSSSFIAS ATPTWVATGS SSGMITLLDT
RTGTILEQWK SHHDSPVNKL IAQGSRYLIS CGDKSVIQWD LHQSPPIISK MWKGFKDNIT
NASLYQNDLI VSSGHKLSSM TLLDDPYQLT SGGGNQNTFR VDGLKLNTPK QSNILSLSFF
PLHHVLLAGT DDGFIKICQ
//
