ID LYPL1_PONAB Reviewed; 237 AA.
AC Q5R8C2; Q5RB27;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=Lysophospholipase-like protein 1 {ECO:0000250|UniProtKB:Q5VWZ2};
DE EC=3.1.2.22 {ECO:0000250|UniProtKB:Q5VWZ2};
GN Name=LYPLAL1 {ECO:0000250|UniProtKB:Q5VWZ2};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Heart, and Kidney;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Palmitoyl thioesterase that catalyzes depalmitoylation of
CC CGAS and KCNMA1. Acts as a regulator of innate immunity by mediating
CC depalmitoylation of CGAS, thereby preventing CGAS homodimerization and
CC cyclic GMP-AMP synthase activity. Does not exhibit phospholipase nor
CC triacylglycerol lipase activity, able to hydrolyze only short chain
CC substrates due to its shallow active site.
CC {ECO:0000250|UniProtKB:Q5VWZ2}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) +
CC hexadecanoate + L-cysteinyl-[protein]; Xref=Rhea:RHEA:19233,
CC Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:7896,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950,
CC ChEBI:CHEBI:74151; EC=3.1.2.22;
CC Evidence={ECO:0000250|UniProtKB:Q5VWZ2};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19234;
CC Evidence={ECO:0000250|UniProtKB:Q5VWZ2};
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000250|UniProtKB:Q5VWZ2}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5R8C2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5R8C2-2; Sequence=VSP_017557;
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. AB hydrolase 2
CC family. {ECO:0000305}.
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DR EMBL; CR858831; CAH91033.1; -; mRNA.
DR EMBL; CR859831; CAH91988.1; -; mRNA.
DR RefSeq; NP_001126154.1; NM_001132682.1. [Q5R8C2-1]
DR RefSeq; NP_001128798.1; NM_001135326.1.
DR RefSeq; XP_009235805.1; XM_009237530.1. [Q5R8C2-1]
DR AlphaFoldDB; Q5R8C2; -.
DR SMR; Q5R8C2; -.
DR STRING; 9601.ENSPPYP00000000218; -.
DR ESTHER; ponpy-lypl1; LYsophospholipase_carboxylesterase.
DR Ensembl; ENSPPYT00000000233.2; ENSPPYP00000000218.2; ENSPPYG00000000212.3. [Q5R8C2-1]
DR GeneID; 100173113; -.
DR GeneID; 100189704; -.
DR KEGG; pon:100189704; -.
DR CTD; 127018; -.
DR eggNOG; KOG2112; Eukaryota.
DR GeneTree; ENSGT00940000159171; -.
DR InParanoid; Q5R8C2; -.
DR OMA; LEYPHIK; -.
DR OrthoDB; 4670340at2759; -.
DR Proteomes; UP000001595; Chromosome 1.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0008474; F:palmitoyl-(protein) hydrolase activity; ISS:UniProtKB.
DR GO; GO:0160049; P:negative regulation of cGAS/STING signaling pathway; ISS:UniProtKB.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR003140; PLipase/COase/thioEstase.
DR PANTHER; PTHR10655:SF71; LYSOPHOSPHOLIPASE-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR10655; LYSOPHOSPHOLIPASE-RELATED; 1.
DR Pfam; PF02230; Abhydrolase_2; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Alternative splicing; Cytoplasm; Hydrolase;
KW Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q5VWZ2"
FT CHAIN 2..237
FT /note="Lysophospholipase-like protein 1"
FT /id="PRO_0000227559"
FT ACT_SITE 124
FT /note="Charge relay system"
FT /evidence="ECO:0000250|UniProtKB:O75608"
FT ACT_SITE 179
FT /note="Charge relay system"
FT /evidence="ECO:0000250|UniProtKB:Q5VWZ2"
FT ACT_SITE 211
FT /note="Charge relay system"
FT /evidence="ECO:0000250|UniProtKB:Q5VWZ2"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q5VWZ2"
FT VAR_SEQ 1..68
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_017557"
FT CONFLICT 227
FT /note="T -> R (in Ref. 1; CAH91033)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 237 AA; 26299 MW; 041C69EC618BEE5B CRC64;
MAAASASVLQ RCIVSPAGRH SASLIFLHGS GDSGQGLRMW IKQVLNQDLT FQHIKIIYPT
APPRSYTPMK GGISNVWFDR FKITNDCPEH LESIDVMCQV LTDLIDEEVK SGIKKNRILI
GGFSMGGSMA MHLAYRNHQD VAGVFALSSF LNKASAVYQA LQKSNGVLPE LFQCHGTADE
LVLHSWAEET NSMLKSLGVT TKLHSFPDVY HELSKTELDI LKLWILTKLP GEMEKQK
//
