ID M0HTJ8_9EURY Unreviewed; 752 AA.
AC M0HTJ8;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Efflux transporter {ECO:0000313|EMBL:ELZ87935.1};
GN ORFNames=C452_14200 {ECO:0000313|EMBL:ELZ87935.1};
OS Haloferax alexandrinus JCM 10717.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC Haloferacaceae; Haloferax.
OX NCBI_TaxID=1227458 {ECO:0000313|EMBL:ELZ87935.1, ECO:0000313|Proteomes:UP000011577};
RN [1] {ECO:0000313|EMBL:ELZ87935.1, ECO:0000313|Proteomes:UP000011577}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 10717 {ECO:0000313|EMBL:ELZ87935.1,
RC ECO:0000313|Proteomes:UP000011577};
RX PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT strategies for static and dynamic osmo-response.";
RL PLoS Genet. 10:E1004784-E1004784(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ELZ87935.1}.
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DR EMBL; AOLL01000028; ELZ87935.1; -; Genomic_DNA.
DR RefSeq; WP_004062803.1; NZ_AOLL01000028.1.
DR AlphaFoldDB; M0HTJ8; -.
DR GeneID; 80787729; -.
DR PATRIC; fig|1227458.3.peg.2790; -.
DR Proteomes; UP000011577; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR022813; SecD/SecF_arch_bac.
DR InterPro; IPR000731; SSD.
DR NCBIfam; TIGR00921; 2A067; 1.
DR PANTHER; PTHR30081:SF10; PROTEIN EXPORT MEMBRANE PROTEIN; 1.
DR PANTHER; PTHR30081; PROTEIN-EXPORT MEMBRANE PROTEIN SEC; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 192..208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 215..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 241..259
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 280..300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 312..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 395..413
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 586..603
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 610..629
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 641..661
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 682..701
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 707..730
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 213..340
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT DOMAIN 644..736
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 349..373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 358..373
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 752 AA; 80598 MW; 63D82A8FD90D112E CRC64;
MDKLRQLFSA VGRQVQQRPV AVLLLAVLLI FTAFGGAAQI TSVTGDAAFV ADNPTFDAFT
ESFDRGSIAV LVRGDITEPQ TLHAIDRVDQ QMSTKANVHT VTSPADQVRR EYGRIPDSEA
KIRSVIGSPD YTVVQIVFDT GLSQTEERPI YTQAVEATDW AEFPSGTTVT VTGSAAFSAQ
LSTLIQQSTQ QLLGLAIGLM VVALFFLFRG VRLRLLPIVA VFVGVIYTFG AIGYAGVPNS
TMTSAVFPIL IGLGIDYSVQ FHERYEEELE NHPPREALPQ ALGGIGPPVF VAMLAAALGF
GATWVSTSSP SIIWFAQTSI FGVLLTFIAG ILVLLPLLTL WVRRRGDAED ETPDEDDAPT
TATTTQSQDQ GDSDRVGLVG ELLGRSARIL ASHPVLVLSI ALLIALVGFQ AGGSLDTLAD
TEGFIPQDLP AYTDLQQFRS VAGGGSSTSY DVLVTGTNLK HPATLQWMLD FEHIATQTPL
VQGVDSPATL VKQYNGGQLP QTESGVKRVL ETVPERQKLQ YYNDGRAHIM VYSAQDMTTQ
QALSFLENTR ESIAYSSPPP GVTAEITGTA AIATPSIVEQ INSRNVTTGL GVLFVFILLL
VYYRNLVKAV APLIPMVFVI GWQNIYMYLL DIPVSPLGAS LGAMTVGIGA EYTIIVMDRY
YQEKQRAGVS RLDAVQTAAT RVGKAISVSG MTTVFGFSAL VLSPFPILSG FGFLTVGVVF
LTLIASLATL PPTLVLLDSI AERVAASRSS SS
//
