ID M0JI80_9EURY Unreviewed; 336 AA.
AC M0JI80;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=Inosine-5'-monophosphate dehydrogenase {ECO:0000313|EMBL:EMA07390.1};
GN ORFNames=C438_03352 {ECO:0000313|EMBL:EMA07390.1};
OS Haloferax denitrificans ATCC 35960.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC Haloferacaceae; Haloferax.
OX NCBI_TaxID=662478 {ECO:0000313|EMBL:EMA07390.1, ECO:0000313|Proteomes:UP000011553};
RN [1] {ECO:0000313|EMBL:EMA07390.1, ECO:0000313|Proteomes:UP000011553}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35960 {ECO:0000313|EMBL:EMA07390.1,
RC ECO:0000313|Proteomes:UP000011553};
RX PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT strategies for static and dynamic osmo-response.";
RL PLoS Genet. 10:E1004784-E1004784(2014).
CC -!- SIMILARITY: Belongs to the IMPDH/GMPR family.
CC {ECO:0000256|ARBA:ARBA00005502}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMA07390.1}.
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DR EMBL; AOLP01000004; EMA07390.1; -; Genomic_DNA.
DR AlphaFoldDB; M0JI80; -.
DR PATRIC; fig|662478.6.peg.626; -.
DR Proteomes; UP000011553; Unassembled WGS sequence.
DR GO; GO:0003938; F:IMP dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006164; P:purine nucleotide biosynthetic process; IEA:InterPro.
DR CDD; cd00381; IMPDH; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR005990; IMP_DH.
DR InterPro; IPR001093; IMP_DH_GMPRt.
DR PANTHER; PTHR11911:SF111; INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE; 1.
DR PANTHER; PTHR11911; INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED; 1.
DR Pfam; PF00478; IMPDH; 1.
DR SMART; SM01240; IMPDH; 1.
DR SUPFAM; SSF51412; Inosine monophosphate dehydrogenase (IMPDH); 1.
PE 3: Inferred from homology;
FT DOMAIN 2..311
FT /note="IMP dehydrogenase/GMP reductase"
FT /evidence="ECO:0000259|Pfam:PF00478"
FT REGION 228..257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..251
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 336 AA; 34971 MW; 42018BF41203079E CRC64;
MDLSTNVTPD LRLDTPLVSA AMDTVTEADL AATLSGLGGL GVVHRFLDVD EQAEQVRRVA
EAGGTVSGAV GINEDYLDRT EALLDAGADA VVMDIAHGHM ERCLDAVERI RDEFDPEIVA
GNVVTPAAVE DLWEAGAGCV KVGVGPGSHC TTREVAGAGY PQLTAVSECA ERAHDLGIHV
MADGGIRTSG DAAKALMAGA DTVMMGSFFA GTDEAPGRVV EVDGETYKRS RGMASTEAAD
DREDKQSDVD AGEGVEALTP YKGPVEPLVE EFLGGIRSGV SYCGGHTLAD AREKASFVRV
AASAKEREGA HGVVFAEGPV EVDEEAEREL QAPMAD
//
