ID   M0N9E4_9EURY            Unreviewed;       356 AA.
AC   M0N9E4;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   SubName: Full=Methionine synthase {ECO:0000313|EMBL:EMA53275.1};
GN   ORFNames=C450_08172 {ECO:0000313|EMBL:EMA53275.1};
OS   Halococcus salifodinae DSM 8989.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halococcaceae; Halococcus.
OX   NCBI_TaxID=1227456 {ECO:0000313|EMBL:EMA53275.1, ECO:0000313|Proteomes:UP000011625};
RN   [1] {ECO:0000313|EMBL:EMA53275.1, ECO:0000313|Proteomes:UP000011625}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 8989 {ECO:0000313|EMBL:EMA53275.1,
RC   ECO:0000313|Proteomes:UP000011625};
RX   PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA   Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA   Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT   "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT   strategies for static and dynamic osmo-response.";
RL   PLoS Genet. 10:E1004784-E1004784(2014).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EMA53275.1}.
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DR   EMBL; AOME01000051; EMA53275.1; -; Genomic_DNA.
DR   RefSeq; WP_005042388.1; NZ_AOME01000051.1.
DR   AlphaFoldDB; M0N9E4; -.
DR   STRING; 1227456.C450_08172; -.
DR   PATRIC; fig|1227456.3.peg.1644; -.
DR   OrthoDB; 17656at2157; -.
DR   Proteomes; UP000011625; Unassembled WGS sequence.
DR   GO; GO:0003871; F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:InterPro.
DR   CDD; cd03311; CIMS_C_terminal_like; 1.
DR   Gene3D; 3.20.20.210; -; 1.
DR   InterPro; IPR002629; Met_Synth_C/arc.
DR   InterPro; IPR038071; UROD/MetE-like_sf.
DR   PANTHER; PTHR30519; 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE; 1.
DR   PANTHER; PTHR30519:SF0; 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE; 1.
DR   Pfam; PF01717; Meth_synt_2; 1.
DR   SUPFAM; SSF51726; UROD/MetE-like; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          19..330
FT                   /note="Cobalamin-independent methionine synthase MetE C-
FT                   terminal/archaeal"
FT                   /evidence="ECO:0000259|Pfam:PF01717"
SQ   SEQUENCE   356 AA;  40203 MW;  7064245C41801B06 CRC64;
     MTREQFRPDD HPNEQFILST VVGSYPKPKW LDRVRERYEE SDDFDDANWA EATDDASRLI
     THEHERAGLD AVVDGEMRRN EMVEYFAERI EGYEFNGPVK VWGHNYFDKP SVVEEVEYDD
     SWLVDEFAFT DDVATKPVKV PITGPYTLAS WCFNESYDDD RALALDLADL VNEEIGKLVE
     AGARYIQIDE PALATTPDDH AIVGDCLDRI VAGLPDDVRI GLHVCYGDYS RIYPEILEFP
     IDEFDVELAN GDYEQLDVFK EPEFDLDLAL GVTDVHVAEV ESVEAIEANI EKGLEIVPPE
     RLTVSPDCGV KLLPREVAYG KMANMVEATR NVERKLDDGE IDARALREGA TASADD
//