ID M0NM22_9EURY Unreviewed; 192 AA.
AC M0NM22;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE RecName: Full=Cytidylate kinase {ECO:0000256|HAMAP-Rule:MF_00239};
DE Short=CK {ECO:0000256|HAMAP-Rule:MF_00239};
DE EC=2.7.4.25 {ECO:0000256|HAMAP-Rule:MF_00239};
DE AltName: Full=Cytidine monophosphate kinase {ECO:0000256|HAMAP-Rule:MF_00239};
DE Short=CMP kinase {ECO:0000256|HAMAP-Rule:MF_00239};
GN Name=cmk {ECO:0000256|HAMAP-Rule:MF_00239};
GN ORFNames=C470_13597 {ECO:0000313|EMBL:EMA57725.1};
OS Halorubrum litoreum JCM 13561.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC Haloferacaceae; Halorubrum; Halorubrum distributum group.
OX NCBI_TaxID=1227483 {ECO:0000313|EMBL:EMA57725.1, ECO:0000313|Proteomes:UP000011581};
RN [1] {ECO:0000313|EMBL:EMA57725.1, ECO:0000313|Proteomes:UP000011581}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 13561 {ECO:0000313|EMBL:EMA57725.1,
RC ECO:0000313|Proteomes:UP000011581};
RX PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT strategies for static and dynamic osmo-response.";
RL PLoS Genet. 10:E1004784-E1004784(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + CMP = ADP + CDP; Xref=Rhea:RHEA:11600,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:58069, ChEBI:CHEBI:60377,
CC ChEBI:CHEBI:456216; EC=2.7.4.25;
CC Evidence={ECO:0000256|ARBA:ARBA00001097, ECO:0000256|HAMAP-
CC Rule:MF_00239};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + dCMP = ADP + dCDP; Xref=Rhea:RHEA:25094,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:57566, ChEBI:CHEBI:58593,
CC ChEBI:CHEBI:456216; EC=2.7.4.25;
CC Evidence={ECO:0000256|ARBA:ARBA00001115, ECO:0000256|HAMAP-
CC Rule:MF_00239};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|HAMAP-Rule:MF_00239}.
CC -!- SIMILARITY: Belongs to the cytidylate kinase family. Type 2 subfamily.
CC {ECO:0000256|ARBA:ARBA00011005, ECO:0000256|HAMAP-Rule:MF_00239}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMA57725.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AOJF01000056; EMA57725.1; -; Genomic_DNA.
DR RefSeq; WP_004595249.1; NZ_AOJF01000056.1.
DR AlphaFoldDB; M0NM22; -.
DR PATRIC; fig|1227483.3.peg.2709; -.
DR Proteomes; UP000011581; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0036430; F:CMP kinase activity; IEA:RHEA.
DR GO; GO:0036431; F:dCMP kinase activity; IEA:RHEA.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0006220; P:pyrimidine nucleotide metabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd02020; CMPK; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00239; Cytidyl_kinase_type2; 1.
DR InterPro; IPR011892; Cyt_kin_arch.
DR InterPro; IPR011994; Cytidylate_kinase_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR02173; cyt_kin_arch; 1.
DR Pfam; PF13189; Cytidylate_kin2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|HAMAP-Rule:MF_00239};
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00239};
KW Kinase {ECO:0000256|HAMAP-Rule:MF_00239, ECO:0000313|EMBL:EMA57725.1};
KW Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00239};
KW Transferase {ECO:0000256|HAMAP-Rule:MF_00239, ECO:0000313|EMBL:EMA57725.1}.
FT BINDING 7..15
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00239"
SQ SEQUENCE 192 AA; 21736 MW; 6AD84E0749644E94 CRC64;
MLITVSGPPG SGKSTNAVQL ADALGLGHVS GGDIFREMAA ERDMTPVEFN EFAEEDPQID
RDLDRRLREI AVERDDVVLE SRLAGWLAAD HADFRFWFDA PLSVRAERIA EREAKPVDRA
ATETERREAS ERKRYREYYD IDIDDLSIYD AAYNTARWGP ERFLDVLVAT VEAYDPDDDE
GKAPVEGVSY DF
//