ID   M0NWN1_9EURY            Unreviewed;       588 AA.
AC   M0NWN1;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE            EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN   ORFNames=C468_11192 {ECO:0000313|EMBL:EMA62362.1};
OS   Halorubrum kocurii JCM 14978.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC   Halorubraceae; Halorubrum.
OX   NCBI_TaxID=1230456 {ECO:0000313|EMBL:EMA62362.1, ECO:0000313|Proteomes:UP000011546};
RN   [1] {ECO:0000313|EMBL:EMA62362.1, ECO:0000313|Proteomes:UP000011546}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 14978 {ECO:0000313|EMBL:EMA62362.1,
RC   ECO:0000313|Proteomes:UP000011546};
RX   PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA   Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA   Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT   "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT   strategies for static and dynamic osmo-response.";
RL   PLoS Genet. 10:E1004784-E1004784(2014).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EMA62362.1}.
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DR   EMBL; AOJH01000068; EMA62362.1; -; Genomic_DNA.
DR   RefSeq; WP_008848927.1; NZ_AOJH01000068.1.
DR   AlphaFoldDB; M0NWN1; -.
DR   STRING; 1230456.C468_11192; -.
DR   PATRIC; fig|1230456.3.peg.2223; -.
DR   OrthoDB; 106630at2157; -.
DR   Proteomes; UP000011546; Unassembled WGS sequence.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd16936; HATPase_RsbW-like; 1.
DR   CDD; cd00130; PAS; 2.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 2.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR001610; PAC.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR000700; PAS-assoc_C.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR013656; PAS_4.
DR   InterPro; IPR013655; PAS_fold_3.
DR   NCBIfam; TIGR00229; sensory_box; 2.
DR   PANTHER; PTHR43304:SF1; PAC DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR43304; PHYTOCHROME-LIKE PROTEIN CPH1; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF08447; PAS_3; 1.
DR   Pfam; PF08448; PAS_4; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00086; PAC; 2.
DR   SMART; SM00091; PAS; 2.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR   PROSITE; PS50113; PAC; 1.
DR   PROSITE; PS50112; PAS; 2.
PE   4: Predicted;
FT   DOMAIN          10..73
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   DOMAIN          121..195
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   DOMAIN          197..248
FT                   /note="PAC"
FT                   /evidence="ECO:0000259|PROSITE:PS50113"
FT   REGION          367..426
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          537..588
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        543..567
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   588 AA;  63951 MW;  5046D1D6BC97957B CRC64;
     MAESPDPEVL LDLAGDKIAV LDEDGIFRHL NAAVTDLLGF RSDELVGTDA LALVHPDEEA
     RLRAILAEIV SGDPAPDEPL EYRYRTADAG WVWLRTTVHL PEETGIDGYV LTSRDITAEV
     ESRRRLETIA SVSGDVFWMF SSGWDELLFV NESVEEVFGV PADALERRPE SFLDAVHPDD
     RPYVKRAMKR LSNGESTRID YRLGPADGVT RWVRVPGEPV IENGEVVAVA GFARDVTEEY
     RRERQLAVMD NLLRHTIRND MNIVDGTAER IADAVAEADA FDAEVGDGRI DPDALAELGA
     GLQEHAETIR RVASDLLTTA EKQRGVIDLL RQRGSPRTVE VAPVVEEALG MVVDDCDEAI
     DIGYREPMDD AGASEKGFGG GAETGAGSRF GAETETGARS ADGGPVDETA NGDSESSPRV
     SVSYPPNARA FTHPELDYAI AELVENAIEH AESTPRVRID VRATDEVIEV SIHDNCPPIP
     VEERYVITDR WEMDDLRHTG GMGLWLVYWV ANRSGGDLNF DTHGDGNIVT LTVPNAKTDA
     SVEGSREPGR SNRSETGGVE RADTRIRTDG SVPSAPDGGE DDDTDGAN
//