ID M0QE44_9ACTN Unreviewed; 1125 AA.
AC M0QE44;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=GS4_03_00490 {ECO:0000313|EMBL:GAC66601.1};
OS Gordonia soli NBRC 108243.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Gordoniaceae;
OC Gordonia.
OX NCBI_TaxID=1223545 {ECO:0000313|EMBL:GAC66601.1, ECO:0000313|Proteomes:UP000011666};
RN [1] {ECO:0000313|EMBL:GAC66601.1, ECO:0000313|Proteomes:UP000011666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 108243 {ECO:0000313|EMBL:GAC66601.1,
RC ECO:0000313|Proteomes:UP000011666};
RA Isaki-Nakamura S., Hosoyama A., Tsuchikane K., Ando Y., Baba S., Ohji S.,
RA Hamada M., Tamura T., Yamazoe A., Yamazaki S., Fujita N.;
RT "Whole genome shotgun sequence of Gordonia soli NBRC 108243.";
RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAC66601.1}.
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DR EMBL; BANX01000003; GAC66601.1; -; Genomic_DNA.
DR RefSeq; WP_007616956.1; NZ_BANX01000003.1.
DR AlphaFoldDB; M0QE44; -.
DR STRING; 1223545.GS4_03_00490; -.
DR eggNOG; COG0210; Bacteria.
DR eggNOG; COG2887; Bacteria.
DR OrthoDB; 4812256at2; -.
DR Proteomes; UP000011666; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF55; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000011666}.
FT DOMAIN 17..370
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 371..690
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 38..45
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1125 AA; 121756 MW; 449092A33419AFEE CRC64;
MTDRISATSL AAALGLPTPT PEQVAVIEAP MEPVLVVAGA GAGKTETMAS RVVWLVANRM
VGPEEILGLT FTRKAASELG ARIRRRLSML AGSPALLHWD PDGALASRLR SADPEVSTYH
AYAGRLIADY GLLLPVEPSS TLLSETELWQ LAFSVVSSWP EELDTAKVPA GVTEAVLKLY
SEMAEHLVDV EDLRHSGDDL QRLIETLPKG PRQRDAPTQA LLKVSDVIDE RRELIPMVLA
LVEAMRQQSA LDFGSQMSMA ARLVVEHPEV ADEERRSVRA VLLDEYQDTG HSQRILLSTL
FGRILSGAGG SKGAGPAGTV AVTAVGDPIQ SIYGWRGASA ANLPRFTTDF PKADGSPADR
LELLTSWRNS ANALRLANET SEELRRRGIP VSVLRSRPGA PQGTAHLALT ETVVDERAWI
ADHVEQHYRR AEEEGTAPPT TAVLVRRNED SAPIAAELER RGIPAEVVGI GGLLHVPEIE
DIVATLRLIA DPMAGTAAMR LLTGGRWQLG AADLAALWRR ATELAAEEFA ISSGVVTSRE
ELDAALDAAL PTEIVDRAGI ADAIVDPGEP QRYSPEGFAR IRAFGAQLES LRRRIGQPLP
ELVADVEHTI GVGVEAQIRA RRMRGAITGR EHLDAFAEYV TRYADRPGAN LPGLLAFLDT
AETIEKGLEQ GRIEVAEQRV QILTVHAAKG LEWDVVALPH VCRGIFPGGR NEGTWLGSSK
ELPADLRGDL ADDTAEGFPR LSLESVGDRK ELENALTEHK EAIAQRRLEE DRRLLYVALT
RAKEALLVSA HQWSESGDKP RGGSDFFDEI RDIVVTAIDD PATDSEGLVV DVLADDPPDG
ATNPLAEQVI RAPWPRDLLG SRRDATARGA RLVLDALAAR DAPSLFAEPA TDAYPASADE
NGDPEVKAWR AEVAALLAEH HQGNQALVDV ELPTHLSVSQ LVELDSDEQV FAQRLRRPTP
FRPNPIARRG TAFHAWLERW FGATRLLDID ELPGAADATA SPDADLDALR DAFLASPWAN
RTPAEVEVPF ETVIGGTVVR GRIDAVFAEP DGGWIVVDWK TGSVPEPARR SSLAVQLAAY
RLAWAQLAGV PPERVRAAFH YVRDGHTLEP DVLLDEPALA ALLAR
//
