ID   M0QNT2_9ACTN            Unreviewed;       364 AA.
AC   M0QNT2;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   SubName: Full=Putative 3-isopropylmalate dehydrogenase {ECO:0000313|EMBL:GAC69916.1};
GN   ORFNames=GS4_29_00150 {ECO:0000313|EMBL:GAC69916.1};
OS   Gordonia soli NBRC 108243.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Gordoniaceae;
OC   Gordonia.
OX   NCBI_TaxID=1223545 {ECO:0000313|EMBL:GAC69916.1, ECO:0000313|Proteomes:UP000011666};
RN   [1] {ECO:0000313|EMBL:GAC69916.1, ECO:0000313|Proteomes:UP000011666}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 108243 {ECO:0000313|EMBL:GAC69916.1,
RC   ECO:0000313|Proteomes:UP000011666};
RA   Isaki-Nakamura S., Hosoyama A., Tsuchikane K., Ando Y., Baba S., Ohji S.,
RA   Hamada M., Tamura T., Yamazoe A., Yamazaki S., Fujita N.;
RT   "Whole genome shotgun sequence of Gordonia soli NBRC 108243.";
RL   Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC       dehydrogenases family. {ECO:0000256|ARBA:ARBA00007769}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAC69916.1}.
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DR   EMBL; BANX01000029; GAC69916.1; -; Genomic_DNA.
DR   RefSeq; WP_007623441.1; NZ_BANX01000029.1.
DR   AlphaFoldDB; M0QNT2; -.
DR   STRING; 1223545.GS4_29_00150; -.
DR   eggNOG; COG0473; Bacteria.
DR   OrthoDB; 5289857at2; -.
DR   Proteomes; UP000011666; Unassembled WGS sequence.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR   InterPro; IPR019818; IsoCit/isopropylmalate_DH_CS.
DR   InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR   PANTHER; PTHR11835; DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE; 1.
DR   PANTHER; PTHR11835:SF34; ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR   Pfam; PF00180; Iso_dh; 1.
DR   SMART; SM01329; Iso_dh; 1.
DR   SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
DR   PROSITE; PS00470; IDH_IMDH; 1.
PE   3: Inferred from homology;
KW   Manganese {ECO:0000256|ARBA:ARBA00023211};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011666}.
FT   DOMAIN          13..358
FT                   /note="Isopropylmalate dehydrogenase-like"
FT                   /evidence="ECO:0000259|SMART:SM01329"
SQ   SEQUENCE   364 AA;  38601 MW;  9DC036CCE810AA16 CRC64;
     MDATHDDRSQ RHRIGVLFGD GIGPEIVPAA VEIADRAAAL EHTGFDWVEA PLGHAAIERY
     GSPVPDETLC VLDELDVWIM GPHDSASYPP DVGGGHTPGA IVRTRYDLYA NLRPCRAIPG
     VRATAPDIDV LIVRENSEGL YADRNMALGS GEFMPTPDVA LSVGVITRAA TTRIAREAFR
     AASRRRRAVT IVHKANVLRM TTGLFRDVCR EVAEDYPEVT VTEQHIDAMA AHLVRRPADF
     DVLVTENLFG DILSDLAAEL AGSLGIAGSV NASATTAMAQ AAHGAAPDIA GLGVADPIAV
     IASTAMVLRW WAEHDDRRSA LEAVADRIDA AIAATAAAGV VTADLGGDAT TRQFTDHVLS
     ELGR
//