ID M0QSJ9_TUPCH Unreviewed; 1582 AA.
AC M0QSJ9;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Sodium channel protein type 4 subunit alpha {ECO:0000313|EMBL:ELW67497.1};
GN ORFNames=TREES_T100002831 {ECO:0000313|EMBL:ELW67497.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW67497.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
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DR EMBL; KB320609; ELW67497.1; -; Genomic_DNA.
DR STRING; 246437.M0QSJ9; -.
DR eggNOG; KOG2301; Eukaryota.
DR InParanoid; M0QSJ9; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:InterPro.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR008052; Na_channel_a4su_mammal.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF223; SODIUM CHANNEL PROTEIN TYPE 4 SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR PRINTS; PR01665; NACHANNEL4.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ion channel {ECO:0000313|EMBL:ELW67497.1};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 191..211
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..388
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 516..534
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 546..564
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 584..605
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 626..654
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 684..701
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 713..739
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1024..1042
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1063..1079
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1124..1150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1248..1271
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1342..1360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1372..1390
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1402..1422
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1459..1487
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1560..1578
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 97..393
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 515..744
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 753..1018
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 1022..1280
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1341..1579
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 36..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 435..465
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 797..854
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 870..921
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 936..982
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 395..429
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 812..839
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 967..982
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1582 AA; 178690 MW; 106C1516267D0747 CRC64;
MPNPSVPTLP LGPHCLRPFT RESLAAIEQR AVEEEARLQR NKQMEIEEPE RKPRSDLEAG
KSLPLIFGDP PPEVIGIPLE DLDPYYSDKK ALAGPLFTRY TFTGIYTFES LIKMLARGFC
IDDFTFLRDP WNWLDFSVIL MAYVTEFVDL GNISALRTFR VLRALKTITV IPGLKTIVGA
LIQSVKKLSD VMILTVFCLS VFALVGLQLF MGNLRQKCVR WPPPFNDTNT TWYGNDTWYS
NDTWYNDTWN NDTWNSQESW AGNSTFDWDA YINDEGNFYF LEGANDALLC GNSSDAGHCP
EGYECIKAGR NPNYGYTSFD TLSPAXXXXX XXXXXXFRLM TQDYWENLFQ LTLRAAGKTY
MIFFVVIIFL GSFYLINLIL AVVAMAYAEQ NEATLAEDQE KEEEFQQMLE KFKKQQEELE
KAKAAQALEG GEAVGDPAIT KDCNGSLDTA PGEKGPPRQS CSADSAISDA MEELEEAHQK
CPPWWYKCAH KVLIWNCCAP WVKFKHIIHL IVMDPFVDLG ITICIVLNTL FMAMEHYPMT
EEFDSVLTVG NLVFTGIFTA EMVLKLIAMD PYEYFQQGWN IFDSFIVTLS LVELGLANVQ
GLSVLRSFRL LRVFKLAKSW PTLNMLIKII GNSVGALGNL TLVLAIIVFI FAVVGMQLFG
KSYKDCVCKI AGDCSLPRWH MHDFFHSFLI VFRILCGEWI ETMWDCMEVA GQAMCLTVFL
MVMVIGNLVV LNLFLALLLS SFSADSLAAS DEDGEMNNLQ IAIGRIKWGI GFAKAFLMGL
LRGKILSPKD IMLSLGKPGG AQEAAEAGEA GEGGPEGEKK EPPPEEGDKD LKKDNHILNH
VGLADGPPSS IELDHLNFIN NPYLTIQVPI ASEESDLEMP TEEETDTFSE PEDGKGPRPS
HVGVALQREG PGRPQACSAP KFRPAGSLWF REQHSADSLV QRRKPPPPLY DGNSSICSTA
DYKPPEEDPE EQVEEDPEGE QPEECFTEAC VQRCPCLYVD ISQGRGKMWW TLRRACFKIV
EHNWFETFIV FMILLSSGAL AFEDIYIEQR RVIRTILEYA DKVFTYIFIL EMLLKWVAYG
FKVSIISLVA NWLGYSELGP IKSLRTLRAL RPLRALSRFE GMRVVVNALL GAIPSIMNVL
LVCLIFWLIF SIMGVNLFAG KFYYCINTTT SERFEISEVN NKSECESLMH TGQVRWLNVK
VNYDNVGLGY LSLLQVATFK GWMDIMYAAV DSREKEEQPS YEVNLYMYLY FVIFIIFGSF
FTLNLFIGVI IDNFNQQKKK MNPKLTGPIP LYFGGKDIFM TEEQKKYYNA MKKLGSKKPQ
KPIPRPQNKI QGMVYDFVTK QVFDIAIMIL ICLNMVTMMV ETDDQSQLKV DILYNINMVF
IIIFTGECVL KMLALRQYYF TVGWNIFDFV VVILSIVGLA LSDLIQKYFV SPTLFRVIRL
ARIGRVLRLI RGAKGIRTLL FALMMSLPAL FNIGLLLFLV MFIYSIFGMS NFAYVKKESG
IDDMFNFETF GNSIICLFEI TTSAGWDGLL NPILNSGPPD CDPTLENPGT SIRGDCGNPS
IGICFFCSYI IISFLIVVNQ AP
//
