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Database: UniProt
Entry: M0QSZ7_TUPCH
LinkDB: M0QSZ7_TUPCH
Original site: M0QSZ7_TUPCH 
ID   M0QSZ7_TUPCH            Unreviewed;      1626 AA.
AC   M0QSZ7;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   07-JUN-2017, entry version 31.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   ORFNames=TREES_T100019812 {ECO:0000313|EMBL:ELW47111.1};
OS   Tupaia chinensis (Chinese tree shrew).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX   NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW47111.1, ECO:0000313|Proteomes:UP000011518};
RN   [1] {ECO:0000313|Proteomes:UP000011518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Zhang G., Fan Y., Yao Y., Huang Z.;
RT   "Genome of the Chinese tree shrew, a rising model animal genetically
RT   related to primates.";
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; KB321144; ELW47111.1; -; Genomic_DNA.
DR   ProteinModelPortal; M0QSZ7; -.
DR   InParanoid; M0QSZ7; -.
DR   Proteomes; UP000011518; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   SMART; SM00015; IQ; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000011518};
KW   Ion channel {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000313|EMBL:ELW47111.1};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     93    111       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    171    191       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    321    348       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    575    593       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    605    623       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    685    713       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    775    798       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1024   1042       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1063   1085       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1091   1111       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1154   1172       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1184   1202       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1209   1234       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1271   1299       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1375   1398       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      129    355       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      398    564       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      575    803       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      812   1018       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1022   1141       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1153   1408       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      345    407       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1626 AA;  184761 MW;  27E9160303E44C2D CRC64;
     MAQSVLVPPG PDSFRFFTRE SLAAIEQRIA EEKAKRPKQE RKDEDDENGP KPNSDLEAGK
     SLPFIYGDIP PEMVSEPLED LDPFYINKKS PTLFNVLIMC TILTNCVFMT MSNPPDWTKN
     VEYVTEFVDL GNVSALRTFR VLRALKTISV IPGLKTIVGA LIQSVKKLSD VMILTVFCLS
     VFALIGLQLF MGNLRNKCLQ WPPDNSSFEI NITAFFNNSL DGNGTTFNRT VNMFNWDDYI
     EDKSHFYFLE GQNDALLCGN SSDAGQCPEG YICVKAGRNP NYGYTSFDTF SWAFLSLFRL
     MTQDFWENLY QLTLRAAGKT YMIFFVLVIF LGSFYLINLI LAVVAMAYEE QNQATLEEAE
     QKEAEFQQML EQLKKQQEEA QLSSKSEKEL KNRRKKKKQK EQSGEEEKED GVRKSESEDS
     IRRKGFRFSL EGSRLTYEKR FSSPHQSLLS IRGSLFSPRR NSRASLFSFR GRAKDIGSEN
     DFADDEHSTF EDNDSRRDSL FVPHKHGERR HSNVSQASRA SRLMPILPMN GKMHSAVDCN
     GVVSLVGGPS ALTSPAGQLL PEVKHLVNLV VMDPFVDLAI TICIVLNTLF MAMEHYPMTE
     QFSSVLSVGN LVFTGIFTAE MFLKIIAMDP YYYFQEGWNI FDGFIVSLSL MELGLANVEG
     LSVLRSFRLL RVFKLAKSWP TLNMLIKIIG NSVGALGNLT LVLAIIVFIF AVVGMQLFGK
     SYKECVCKIS NDCELPRWHM HDFFHSFLIV FRVLCGEWIE TMWDCMEVAG QTMCLTVFMM
     VMVIGNLVVL NLFLALLLSS FSSDNLAATD DDNEMNNLQI AVGRMQKGID FVKRKIREFI
     QKAFVRKQKA LDEIKPLEDL NNKKDSCISN HTTIEIGKDL NYLKDGNGTT SGIGSSVEKY
     VVDESDYMSF INNPSLTVTV PIAVGESDFE NLNTEEFSSE SDMEESKEKL NATSSSEGST
     VDIGAPAEGE QPEVEPEESL EPEACFTEDC VRKFKCCQIS IEEGKGKLWW NLRKTCYKIV
     EHNWFETFIV FMILLSSGAL AFEDIYIEQR KTIKTMLEYA DKVFTYIFIL EMLLKWVAYG
     FQMYFTNAWC WLDFLIVDVS LVSLTANALG YSELGAIKSL RTLRALRPLR ALSRFEGMRN
     KFQGMVFDFV TKQVFDISIM ILICLNMVTM MVETDDQSQE MTNILYWINL VFIVLFTGEC
     VLKLISLRYY YFTIGWNIFD FVVVILSIVG MFLAELIEKY FVSPTLFRVI RLARIGRILR
     LIKGAKGIRT LLFALMMSLP ALFNIGLLLF LVMFIYAIFG MSNFAYVKRE VGIDDMFNFE
     TFGNSMICLF QITTSAGWDG LLAPILNSGP PDCDPEKDHP GSSVKGDCGN PSVGIFFFVS
     YIIISFLVVV NMYIAVILEN FSVATEESAE PLSEDDFEMF YEVWEKFDPD ATQFIEFSKL
     SDFAAALDPP LLIAKPNKVQ LIAMDLPMVS GDRIHCLDIL FAFTKRVLGE SGEMDALRIQ
     MEERFMASNP SKVSYEPITT TLKRKQEEVS AIIIQRAYRR YLLKQKVKKV SCIYKKDKGK
     ECDGTPIKED VIDKLNENST PEKTDMTPST TSPPSYDSVT KPEKEKYEKD KSEKEDKGKD
     IRESKK
//
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