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Database: UniProt
Entry: M0QT16_TUPCH
LinkDB: M0QT16_TUPCH
Original site: M0QT16_TUPCH 
ID   M0QT16_TUPCH            Unreviewed;      1734 AA.
AC   M0QT16;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   25-OCT-2017, entry version 31.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   ORFNames=TREES_T100003173 {ECO:0000313|EMBL:ELW62310.1};
OS   Tupaia chinensis (Chinese tree shrew).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX   NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW62310.1, ECO:0000313|Proteomes:UP000011518};
RN   [1] {ECO:0000313|Proteomes:UP000011518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Zhang G., Fan Y., Yao Y., Huang Z.;
RT   "Genome of the Chinese tree shrew, a rising model animal genetically
RT   related to primates.";
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; KB320830; ELW62310.1; -; Genomic_DNA.
DR   ProteinModelPortal; M0QT16; -.
DR   InParanoid; M0QT16; -.
DR   Proteomes; UP000011518; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0048266; P:behavioral response to pain; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   InterPro; IPR028803; SCN9A.
DR   PANTHER; PTHR10037:SF221; PTHR10037:SF221; 3.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   SMART; SM00015; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000011518};
KW   Ion channel {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000313|EMBL:ELW62310.1};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    170    189       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    201    222       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    228    247       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    358    385       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    701    729       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    791    814       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1039   1057       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1078   1094       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1106   1126       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1170   1190       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1293   1311       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1323   1343       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1380   1408       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1484   1507       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      137    391       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      464    631       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      628    819       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      828   1033       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1037   1248       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1261   1517       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      382    420       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1734 AA;  196789 MW;  E8479485E05AB20D CRC64;
     MAMLPPPGPQ SFVHFTKQSL ALIEQRIAEG KAKEPKEEKK DDDEEGPKPS SDLEAGKQLP
     FIYGDIPPGM VSEPLEDLDP YYADKKTFIV LNKGKAIFRF NATPALYLLS PFSPLRRISI
     KILVHSYPFQ YAYLQGYTFT GIYTFESLVK ILARGFCVGE FTFLRDPWNW LDFIVIVFAY
     LTEFVNLGNV SALRTFRVLR ALKTISVIPG LKTIVGALIQ SVKKLSDVMI LTVFCLSVFA
     LIGLQLFMGN LKHKCLRDEL GSNKTLEDLL KTLETEEEFR KYFYYLEGYK DALLCGFSTD
     SGQCPEGYHC VKAGRNPDYG YTSFDTFSWA FLALFRLMTQ DFWENLYQQT LRAAGKTYMI
     FFVVVIFLGS FYLINLILAV VAMAYEEQNQ ANIEEAKQKE LEFQQMLDRL KKEQEEAEAI
     AMAAAEYTSI GRSRIMGLSE SSSETSKLSS KSAKERRNRR KKKNQKKLSS GEEKGDDEKL
     SKSESEESIR RKSFHLGVEG PRRAREKRLS TPNQSPLSIR GSLFSARRSS RTSLFSFKGR
     GKDIGSETEF ADDEHSIFGD NESRRGSLFV PHRPQERRSS NISQASRSPP MLPVNGKMHS
     AVDCNGVVSL VDGPSALMLP NGQLLPEVFT GIFAAEMVLK LIAMDPYEYF QVGWNIFDSL
     IVTLSLVELF LSDVEGLSVL RSFRLLRVFK LAKSWPTLNM LIKIIGNSVG ALGNLTLVLA
     IIVFIFAVVG MQLFGKSYKE CVCKISSDCE LPRWHMHDFF HSFLIVFRVL CGEWIETMWD
     CMEVAGQAMC LIVYMMVMVI GNLVVLNLFL ALLLSSFSSD NLTAIEEDTD ANNLQIAVAR
     IQRGINYVKQ NLREFILKAF SKKPKISKEI GRAEDLNNKK GNYISNRTLA EMNKDHDFQK
     EKDKISGFGS SMDRYLMEES DCQSFIHNPS LTVTVPIAPG ESDLENMNTE ELSSDSDSEY
     SKERLNRSSS SECSTVDNPL PGEGEEAEAE PVNSDEPEAC FTDGCVRRFP CCQVNTESGK
     GKIWWNIRKT CYRIVEHSWF ESFIVLMILL SSGALAFEDI YIERKKTIKI ILEYADKIFT
     YIFILEMLLK WVAYGYKTYF TNAWCWLDFL IVDVSLITLV ASTLGYSDLG PIKSLRTLRA
     LRPLRALSRF EGMRVVVNAL IGAIPSIMNV LLVCLIFWLI FSIMGVNLFA GKFYECVNTT
     DGSRFSESQV SNYTECMALM NISQDVRWKN LKVNFDNVGL GYLSLLQVNK FQGCIFDMVT
     NQVFDITIMV LICLNMVTMM VEKEGQSNYM TTVLHWINVV FIILFTGECV LKLISLRHYY
     FTVGWNIFDF VVVILSIVGM FLAELIEKYF VSPTLFRVIR LARIGRILRL IKGAKGIRTL
     LFALMMSLPA LFNIGLLLFL VMFIYAIFGM SNFAYVKKEA GINDMFNFET FGNSMICLFQ
     ITTSAGWDGL LAPILNSGPP DCDPKKVHPG SSVEGDCGNP SVGIFYFVSY IIISFLVVVN
     MYIAVILENF SVATEESTEP LSEDDFEMFY EVWEKFDPDA TQFIEYSKLS DFAAALDPPL
     LIAKPNKVQL IAMDLPMVSG DRIHCLDILF AFTKRVLGES GEMDSLRSQM EERFMSANPS
     KVSYEPITTT LKRKQEDVSA TVIQRAYRRY RLRQNVKNIS SIYIKDGDRD DDFPNKEDTV
     FDNVNENSSP EKNNVTPSSV SPPSYDSVTK PDKEKYEKDK TEKEDRWKDD DKES
//
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