ID M0R2S7_HUMAN Unreviewed; 1330 AA.
AC M0R2S7;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Mucin 16, cell surface associated {ECO:0000313|Ensembl:ENSP00000472781.1};
DE Flags: Fragment;
GN Name=MUC16 {ECO:0000313|Ensembl:ENSP00000472781.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000472781.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000472781.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2] {ECO:0000313|Ensembl:ENSP00000472781.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AC008734; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC016584; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF456494; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR MassIVE; M0R2S7; -.
DR MaxQB; M0R2S7; -.
DR PeptideAtlas; M0R2S7; -.
DR Antibodypedia; 3492; 1294 antibodies from 39 providers.
DR Ensembl; ENST00000599436.1; ENSP00000472781.1; ENSG00000181143.16.
DR UCSC; uc060syc.1; human.
DR HGNC; HGNC:15582; MUC16.
DR VEuPathDB; HostDB:ENSG00000181143; -.
DR GeneTree; ENSGT00440000039287; -.
DR HOGENOM; CLU_273093_0_0_1; -.
DR ChiTaRS; MUC16; human.
DR Proteomes; UP000005640; Chromosome 19.
DR Bgee; ENSG00000181143; Expressed in nasal cavity epithelium and 79 other cell types or tissues.
DR ExpressionAtlas; M0R2S7; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.960; SEA domain; 9.
DR InterPro; IPR028850; MUC16.
DR InterPro; IPR000082; SEA_dom.
DR InterPro; IPR036364; SEA_dom_sf.
DR PANTHER; PTHR14672; MUCIN-16; 1.
DR PANTHER; PTHR14672:SF1; MUCIN-16; 1.
DR Pfam; PF01390; SEA; 9.
DR SUPFAM; SSF82671; SEA domain; 9.
DR PROSITE; PS50024; SEA; 9.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|MaxQB:M0R2S7,
KW ECO:0007829|PeptideAtlas:M0R2S7};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1273..1299
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 5..126
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DOMAIN 161..282
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DOMAIN 317..438
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DOMAIN 473..594
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DOMAIN 629..749
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DOMAIN 762..883
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DOMAIN 896..1016
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DOMAIN 1021..1132
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DOMAIN 1142..1261
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT REGION 131..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 443..465
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000472781.1"
SQ SEQUENCE 1330 AA; 148284 MW; ABBEBCFAC47A328B CRC64;
XTGPLLVPFT LNFTITNLQY EENMGHPGSR KFNITESVLQ GLLKPLFKST SVGPLYSGCR
LTLLRPEKDG VATRVDAICT HRPDPKIPGL DRQQLYWELS QLTHSITELG PYTLDRDSLY
VNGFTQRSSV PTTSTPGTFT VQPETSETPS SLPGPTATGP VLLPFTLNFT ITNLQYEEDM
RRPGSRKFNT TERVLQGLLM PLFKNTSVSS LYSGCRLTLL RPEKDGAATR VDAVCTHRPD
PKSPGLDRER LYWKLSQLTH GITELGPYTL DRHSLYVNGF THQSSMTTTR TPDTSTMHLA
TSRTPASLSG PMTASPLLVL FTINFTITNL RYEENMHHPG SRKFNTTERV LQGLLRPVFK
NTSVGPLYSG CRLTLLRPKK DGAATKVDAI CTYRPDPKSP GLDREQLYWE LSQLTHSITE
LGPYTLDRDS LYVNGFTQRS SVPTTSIPGT PTVDLGTSGT PVSKPGPSAA SPLLVLFTLN
FTITNLRYEE NMQHPGSRKF NTTERVLQGL LRSLFKSTSV GPLYSGCRLT LLRPEKDGTA
TGVDAICTHH PDPKSPRLDR EQLYWELSQL THNITELGPY ALDNDSLFVN GFTHRSSVST
TSTPGTPTVY LGASKTPASI FGPSAASHLL ILFTLNFTIT NLRYEENMWP GSRKFNTTER
VLQGLLRPLF KNTSVGPLYS GCRLTLLRPE KDGEATGVDA ICTHRPDPTG PGLDREQLYL
ELSQLTHSIT ELGPYTLDRD SLYVNGFTHR SSVPTTSTGV VSEEPFTLNF TINNLRYMAD
MGQPGSLKFN ITDNVMQHLL SPLFQRSSLG ARYTGCRVIA LRSVKNGAET RVDLLCTYLQ
PLSGPGLPIK QVFHELSQQT HGITRLGPYS LDKDSLYLNG YNEPGPDEPP TTMGYHLKTL
TLNFTISNLQ YSPDMGKGSA TFNSTEGVLQ HLLRPLFQKS SMGPFYLGCQ LISLRPEKDG
AATGVDTTCT YHPDPVGPGL DIQQLYWELS QLTHGVTQLG FYVLDRDSLF INGYAPQNLS
IRGEYQINFH IVNWNLSNPD PTSSEYITLL RDIQDKVTTL YKGSQLHDTF RFCLVTNLTM
DSVLVTVKAL FSSNLDPSLV EQVFLDKTLN ASFHWLGSTY QLVDIHVTEM ESSVYQPTSS
SSTQHFYLNF TITNLPYSQD KAQPGTTNYQ RNKRNIEDAL NQLFRNSSIK SYFSDCQVST
FRSVPNRHHT GVDSLCNFSP LARRVDRVAI YEEFLRMTRN GTQLQNFTLD RSSVLVDGYS
PNRNEPLTGN SDLPFWAVIL IGLAGLLGVI TCLICGVLVT TRRRKKEGEY NVQQQCPGYY
QSHLDLEDLQ
//
