ID M0RAA8_RAT Unreviewed; 1032 AA.
AC M0RAA8;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE RecName: Full=Toll-like receptor 9 {ECO:0000256|ARBA:ARBA00017400};
GN Name=Tlr9 {ECO:0000313|Ensembl:ENSRNOP00000066453.1,
GN ECO:0000313|RGD:631352};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000066453.1, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000066453.1, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000066453.1,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000313|Ensembl:ENSRNOP00000066453.1}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000066453.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome
CC {ECO:0000256|ARBA:ARBA00004262}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004115}. Endosome
CC {ECO:0000256|ARBA:ARBA00004177}. Lysosome
CC {ECO:0000256|ARBA:ARBA00004371}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR AlphaFoldDB; M0RAA8; -.
DR SMR; M0RAA8; -.
DR STRING; 10116.ENSRNOP00000066453; -.
DR PaxDb; 10116-ENSRNOP00000066453; -.
DR Ensembl; ENSRNOT00000074194.2; ENSRNOP00000066453.1; ENSRNOG00000048161.2.
DR AGR; RGD:631352; -.
DR RGD; 631352; Tlr9.
DR eggNOG; KOG4641; Eukaryota.
DR GeneTree; ENSGT00940000162493; -.
DR HOGENOM; CLU_006000_2_0_1; -.
DR OMA; NFLPCCS; -.
DR Reactome; R-RNO-109704; PI3K Cascade.
DR Reactome; R-RNO-1679131; Trafficking and processing of endosomal TLR.
DR Reactome; R-RNO-168138; Toll Like Receptor 9 (TLR9) Cascade.
DR Proteomes; UP000002494; Chromosome 8.
DR Bgee; ENSRNOG00000048161; Expressed in spleen and 9 other cell types or tissues.
DR GO; GO:0016324; C:apical plasma membrane; ISO:RGD.
DR GO; GO:0016323; C:basolateral plasma membrane; ISO:RGD.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0032009; C:early phagosome; ISO:RGD.
DR GO; GO:0036019; C:endolysosome; ISO:RGD.
DR GO; GO:0005783; C:endoplasmic reticulum; ISO:RGD.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005768; C:endosome; ISO:RGD.
DR GO; GO:0005764; C:lysosome; ISO:RGD.
DR GO; GO:0045335; C:phagocytic vesicle; ISO:RGD.
DR GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR GO; GO:0005149; F:interleukin-1 receptor binding; ISO:RGD.
DR GO; GO:0038187; F:pattern recognition receptor activity; ISO:RGD.
DR GO; GO:0035197; F:siRNA binding; ISO:RGD.
DR GO; GO:0045322; F:unmethylated CpG binding; IDA:RGD.
DR GO; GO:0002218; P:activation of innate immune response; ISO:RGD.
DR GO; GO:0007249; P:canonical NF-kappaB signal transduction; ISO:RGD.
DR GO; GO:1902350; P:cellular response to chloroquine; ISO:RGD.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IEP:RGD.
DR GO; GO:0071248; P:cellular response to metal ion; IEP:RGD.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl.
DR GO; GO:0051607; P:defense response to virus; IMP:RGD.
DR GO; GO:0032490; P:detection of molecule of bacterial origin; ISO:RGD.
DR GO; GO:0006955; P:immune response; ISO:RGD.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0030277; P:maintenance of gastrointestinal epithelium; ISO:RGD.
DR GO; GO:0008584; P:male gonad development; IEP:RGD.
DR GO; GO:0001774; P:microglial cell activation; IDA:RGD.
DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; ISO:RGD.
DR GO; GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; ISO:RGD.
DR GO; GO:0010508; P:positive regulation of autophagy; IDA:RGD.
DR GO; GO:0050871; P:positive regulation of B cell activation; ISO:RGD.
DR GO; GO:0030890; P:positive regulation of B cell proliferation; ISO:RGD.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; ISO:RGD.
DR GO; GO:0032722; P:positive regulation of chemokine production; ISO:RGD.
DR GO; GO:0001819; P:positive regulation of cytokine production; ISO:RGD.
DR GO; GO:0010628; P:positive regulation of gene expression; ISO:RGD.
DR GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; ISO:RGD.
DR GO; GO:0002639; P:positive regulation of immunoglobulin production; ISO:RGD.
DR GO; GO:0032727; P:positive regulation of interferon-alpha production; ISO:RGD.
DR GO; GO:0032728; P:positive regulation of interferon-beta production; ISO:RGD.
DR GO; GO:0032733; P:positive regulation of interleukin-10 production; ISO:RGD.
DR GO; GO:0032735; P:positive regulation of interleukin-12 production; ISO:RGD.
DR GO; GO:0032741; P:positive regulation of interleukin-18 production; ISO:RGD.
DR GO; GO:0032755; P:positive regulation of interleukin-6 production; ISO:RGD.
DR GO; GO:0032757; P:positive regulation of interleukin-8 production; ISO:RGD.
DR GO; GO:1905300; P:positive regulation of intestinal epithelial cell development; ISO:RGD.
DR GO; GO:0046330; P:positive regulation of JNK cascade; ISO:RGD.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; ISO:RGD.
DR GO; GO:1901224; P:positive regulation of non-canonical NF-kappaB signal transduction; ISO:RGD.
DR GO; GO:0034165; P:positive regulation of toll-like receptor 9 signaling pathway; ISO:RGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0032760; P:positive regulation of tumor necrosis factor production; ISO:RGD.
DR GO; GO:0032729; P:positive regulation of type II interferon production; ISO:RGD.
DR GO; GO:0050864; P:regulation of B cell activation; ISO:RGD.
DR GO; GO:0045577; P:regulation of B cell differentiation; ISO:RGD.
DR GO; GO:0002730; P:regulation of dendritic cell cytokine production; ISO:RGD.
DR GO; GO:0050727; P:regulation of inflammatory response; ISO:RGD.
DR GO; GO:0001932; P:regulation of protein phosphorylation; ISO:RGD.
DR GO; GO:0034163; P:regulation of toll-like receptor 9 signaling pathway; ISO:RGD.
DR GO; GO:0009615; P:response to virus; ISO:RGD.
DR GO; GO:0034162; P:toll-like receptor 9 signaling pathway; ISO:RGD.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IDA:RGD.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR041283; LRR_12.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR47410; TOLL-LIKE RECEPTOR 7-RELATED; 1.
DR PANTHER; PTHR47410:SF3; TOLL-LIKE RECEPTOR 9; 1.
DR Pfam; PF18837; LRR_12; 1.
DR Pfam; PF13516; LRR_6; 1.
DR Pfam; PF13855; LRR_8; 4.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00365; LRR_SD22; 8.
DR SMART; SM00369; LRR_TYP; 14.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 868..1013
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1032 AA; 116717 MW; 152B2883DB0A2376 CRC64;
MVLCRRTLHP LSLLVQAAML AEALALGTLP AFLPCELKPH GLVDCNWLFL KSVPHFSAAE
PRSNITSLSL IANRIHHLHN LDFVHLPNVR QLNLKWNCPP PGLSPLHFSC RMTIEPKTFL
AMRMLEELNL SYNGITTVPR LPSSLTNLSL SHTNILVLDA SSLAGLHSLR VLFMDGNCYY
KNPCNGAVNV TPDAFLGLSN LTHLSLKYNN LTEVPRQLPS SLEYLLLSYN LIVKLGPEDL
ANLTSLRVLD VGGNCRRCDH APDLCTECRQ KSLDLHPQTF RHLSHLEGLV LKDSSLHSLN
SKWFQGLVNL SVLDLSENFL YESINKTSAF QNLTRLRKLD LSFNYCKKVS FARLHLASSF
KSLVSLQELN MNGIFFRLLN KNTLRWLAGL PKLHTLHLQM NFINQAQLSV FSTFRALRFV
DLSNNRISGP PTLSRVAPEK ADEAEKGVPW PASLTPALPS TPVSKNFMVR CKNLRFTMDL
SRNNLVTIKP EMFVNLSHLQ CLSLSHNCIA QAVNGSQFLP LTNLKVLDLS YNKLDLYHSK
SFSELPQLQA LDLSYNSQPF SMQGIGHNFS FLANLSRLQN LSLAHNDIHS RVSSRLYSTS
VEYLDFSGNG VGRMWDEEDL YLYFFQDLRS LIHLDLSQNK LHILRPQNLN YLPKSLTKLS
FRDNHLSFFN WSSLAFLPNL RDLDLAGNLL KALTNGTLPN GTLLQKLDVS SNSIVFVVPA
FFALAVELKE VNLSHNILKT VDRSWFGPIV MNLTVLDVSS NPLHCACGAP FVDLLLEVQT
KVPGLANGVK CGSPRQLQGR SIFAQDLRLC LDDVLSRDCF GLSLLAVAVG TVLPLLQHLC
GWDVWYCFHL CLAWLPLLTR GRRSAQALPY DAFVVFDKAQ SAVADWVYNE LRVRLEERRG
RRALRLCLED RDWLPGQTLF ENLWASIYGS RKTLFVLAHT DKVSGLLRTS FLLAQQRLLE
DRKDVVVLVI LRPDAHRSRY VRLRQRLCRQ SVLFWPHQPN GQGSFWAQLS TALTRDNHHF
YNRNFCRGPT AE
//
