ID M0ZK11_SOLTU Unreviewed; 444 AA.
AC M0ZK11;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Aminoacylase {ECO:0000313|EnsemblPlants:PGSC0003DMT400002373};
GN Name=102590216 {ECO:0000313|EnsemblPlants:PGSC0003DMT400002373};
OS Solanum tuberosum (Potato).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX NCBI_TaxID=4113 {ECO:0000313|EnsemblPlants:PGSC0003DMT400002373, ECO:0000313|Proteomes:UP000011115};
RN [1] {ECO:0000313|Proteomes:UP000011115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DM1-3 516 R44 {ECO:0000313|Proteomes:UP000011115};
RX PubMed=21743474; DOI=10.1038/nature10158;
RG The Potato Genome Sequencing Consortium;
RT "Genome sequence and analysis of the tuber crop potato.";
RL Nature 475:189-195(2011).
RN [2] {ECO:0000313|EnsemblPlants:PGSC0003DMT400002373}
RP IDENTIFICATION.
RC STRAIN=DM1-3 516 R44 {ECO:0000313|EnsemblPlants:PGSC0003DMT400002373};
RG EnsemblPlants;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|PIRSR:PIRSR036696-2};
CC Note=Binds 2 Zn(2+) ions per subunit. {ECO:0000256|PIRSR:PIRSR036696-
CC 2};
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DR RefSeq; XP_006351890.1; XM_006351828.2.
DR RefSeq; XP_006351891.1; XM_006351829.2.
DR RefSeq; XP_006351892.1; XM_006351830.2.
DR RefSeq; XP_015166174.1; XM_015310688.1.
DR AlphaFoldDB; M0ZK11; -.
DR STRING; 4113.M0ZK11; -.
DR PaxDb; 4113-PGSC0003DMT400002373; -.
DR EnsemblPlants; PGSC0003DMT400002373; PGSC0003DMT400002373; PGSC0003DMG400000909.
DR GeneID; 102590216; -.
DR Gramene; PGSC0003DMT400002373; PGSC0003DMT400002373; PGSC0003DMG400000909.
DR KEGG; sot:102590216; -.
DR eggNOG; KOG2275; Eukaryota.
DR HOGENOM; CLU_021802_5_0_1; -.
DR InParanoid; M0ZK11; -.
DR OMA; MDCVETI; -.
DR OrthoDB; 158507at2759; -.
DR Proteomes; UP000011115; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0004046; F:aminoacylase activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR Gene3D; 1.10.150.900; -; 1.
DR Gene3D; 3.30.70.360; -; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR036264; Bact_exopeptidase_dim_dom.
DR InterPro; IPR010159; N-acyl_aa_amidohydrolase.
DR InterPro; IPR002933; Peptidase_M20.
DR NCBIfam; TIGR01880; Ac-peptdase-euk; 1.
DR PANTHER; PTHR45892; AMINOACYLASE-1; 1.
DR PANTHER; PTHR45892:SF3; PUTATIVE-RELATED; 1.
DR Pfam; PF01546; Peptidase_M20; 1.
DR PIRSF; PIRSF036696; ACY-1; 1.
DR SUPFAM; SSF55031; Bacterial exopeptidase dimerisation domain; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PIRSR:PIRSR036696-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000011115};
KW Signal {ECO:0000256|SAM:SignalP}; Zinc {ECO:0000256|PIRSR:PIRSR036696-2}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..444
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004010636"
FT ACT_SITE 105
FT /evidence="ECO:0000256|PIRSR:PIRSR036696-1"
FT ACT_SITE 172
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR036696-1"
FT BINDING 103
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR036696-2"
FT BINDING 136
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR036696-2"
FT BINDING 136
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR036696-2"
FT BINDING 173
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR036696-2"
FT BINDING 200
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR036696-2"
FT BINDING 410
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR036696-2"
SQ SEQUENCE 444 AA; 50082 MW; F9733D185591AA47 CRC64;
MFDHLQRLPV LFFFLLLSLS FSESLHENKE SDTPISRFQG YLRINTAHPN PNYTDAINYL
TNFANSIPNL HSKVIHLTPT SPLLLLTWPG SNPSLPSILF NSHLDSVPAE PDKWTHPPFS
AHKTSDGRIF ARGAQDDKCI GMQYLEAIKA IQTSDSKFVP LRNVHILYVP EEEVGGFDGM
GKFVELKEFE ELNLGFMMDE GQASPNDEFR VFYADRTPWH TVIKAVGTPG HGSKLYDNTA
MENLMKSMEV ITKFRESMFD MVKAGLAANS EVISVNPVFL NAGTPSPTGF MMNMQPSEAE
AGFDIRMPPT ADPELMRKII EEQWAPAWRN MTYKITEKGF LRDIMGRPLM TLASDSNPWW
SVFNEAVTRA GGKLSKPEIL ASTTDARFMR RLGIPTFGFS PMKNTPILLH DHNENLKDTV
YLEGIKVYEC IIKSLSSFEG SYEH
//
