ID   M0ZTX7_SOLTU            Unreviewed;      1178 AA.
AC   M0ZTX7;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   27-MAR-2024, entry version 54.
DE   SubName: Full=Nbs-lrr resistance protein {ECO:0000313|EnsemblPlants:PGSC0003DMT400008029};
OS   Solanum tuberosum (Potato).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX   NCBI_TaxID=4113 {ECO:0000313|EnsemblPlants:PGSC0003DMT400008029, ECO:0000313|Proteomes:UP000011115};
RN   [1] {ECO:0000313|Proteomes:UP000011115}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. DM1-3 516 R44 {ECO:0000313|Proteomes:UP000011115};
RX   PubMed=21743474; DOI=10.1038/nature10158;
RG   The Potato Genome Sequencing Consortium;
RT   "Genome sequence and analysis of the tuber crop potato.";
RL   Nature 475:189-195(2011).
RN   [2] {ECO:0000313|EnsemblPlants:PGSC0003DMT400008029}
RP   IDENTIFICATION.
RC   STRAIN=DM1-3 516 R44 {ECO:0000313|EnsemblPlants:PGSC0003DMT400008029};
RG   EnsemblPlants;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC       {ECO:0000256|ARBA:ARBA00008894}.
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DR   AlphaFoldDB; M0ZTX7; -.
DR   PaxDb; 4113-PGSC0003DMT400008029; -.
DR   EnsemblPlants; PGSC0003DMT400008029; PGSC0003DMT400008029; PGSC0003DMG400003104.
DR   Gramene; PGSC0003DMT400008029; PGSC0003DMT400008029; PGSC0003DMG400003104.
DR   eggNOG; KOG4658; Eukaryota.
DR   HOGENOM; CLU_000837_8_8_1; -.
DR   InParanoid; M0ZTX7; -.
DR   OMA; VWMFFFQ; -.
DR   Proteomes; UP000011115; Unassembled WGS sequence.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0050832; P:defense response to fungus; IEA:InterPro.
DR   CDD; cd14798; RX-CC_like; 1.
DR   Gene3D; 1.20.5.4130; -; 1.
DR   Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR042197; Apaf_helical.
DR   InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039203; RGA2/3-like.
DR   InterPro; IPR038005; RX-like_CC.
DR   InterPro; IPR041118; Rx_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR36766:SF32; DISEASE RESISTANCE PROTEIN RGA2-LIKE; 1.
DR   PANTHER; PTHR36766; PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   Pfam; PF18052; Rx_N; 1.
DR   PRINTS; PR00364; DISEASERSIST.
DR   SMART; SM00367; LRR_CC; 6.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52047; RNI-like; 1.
PE   3: Inferred from homology;
KW   Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011115}.
FT   DOMAIN          4..89
FT                   /note="Disease resistance N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF18052"
FT   DOMAIN          163..384
FT                   /note="NB-ARC"
FT                   /evidence="ECO:0000259|Pfam:PF00931"
SQ   SEQUENCE   1178 AA;  133019 MW;  22995377938CCCE6 CRC64;
     MREVILEKLA TPYVQKFHDL YHLKENIEKL QNSLPTARAF LDDAQKRQET DQHVENWLVK
     LKDIAYQLEN LLDEFTAESV MCEHRSGKGK QVSSLFLPFE PSKHLFDLAK MLPKKLKELD
     EIAKQGFSLN LRATTTERRA DDYDRTKVTG SFVITSKICG RDDDKKKLLE LLLTACDGKT
     GGVLSIIPIV GIGGLGKTTL AQLVYNDEKV VHFFDIKIWV YVSRDFDVSK LMLSIIQSAT
     KRKCELLEMD LLQAHFQDSL GGKRFLIVLD DVWNEDQEEW DKLGDLLQSG GAGSRIIVTT
     RSTKVASIVG TTSPYCLQGL TEDDCWVLFK QRAFSQEEEA EHPNLLEIGK QIIKKCGGVP
     LAAKTLGSLL RFKREREDWM FVQESELWKL ENCNSGILPA LRLSYLQLPL HLKRCFAFCS
     LYPKNYEIHK EKMIHIWIAE GLITCHERNR QLEDIGNKYF NDLLCLSFFQ EVKKFDETDL
     AVYKMHDLIH DLARSVGSQD FVILGHDFAQ GNMSRVHHLS ILFHSDPTSL PKELYGAKHL
     RTLQFLFCTG DIPSSFPLNF KYLRVLDLSG CVKKVHESIS DLICLRYLDL SRTSIQTLPH
     TICNLFNLQT LNLSFCGNLM ELPFGLANIT GLRHLNIVGC NGLTRLPAGL GNLVQLQTLP
     LYIVGKGIGE SISEISSPHI RGELSIRGLE NIRDKEEATL ANLRAKKYVE LLRLQWGSEN
     IVRMSTGSTS YEVCREVDGT SRSLSRDNDN VVEGIIECLQ PHVNLKKLYI KGYPGFRFPD
     WDLPNLVLIA LINCRGCDTL PTFGKLPFLK TLYLQGMDGV THIGEEFYGG EPLKFPSLED
     LTIKDLPCLK EWSCIENGAA VLPRLQKLVV DKCPNLISAP TFQSLLHLEL HDCHPKILES
     VDNMSSLSNL VIDALQGLVH LSGKLLENNK SLETVEILSC KNFISLPQEI EHLTYLKSLT
     ISYCEKLTHL PTGIRKLQAL EFLEINGCHS LESLPSEEFA GFNSLKSLSI ENCSNLIYLS
     SGFLHLTVLE QLSIMGCPRL TLSRDSFQNL SSLRSLSIIS CPELYPLPVS LQHVTTLQSL
     VIHSSPHLTD LPDWLAKLSS LRSLAISNCE HLISLPEGMK YLNALQHLSI QDCPHLERLC
     KKKGANAVFA GWFITVLTRL STVSKQAYSN GIDMWLSY
//