ID M1A232_SOLTU Unreviewed; 1139 AA.
AC M1A232;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Disease resistance protein RGA3 {ECO:0000313|EnsemblPlants:PGSC0003DMT400012963};
GN Name=102588652 {ECO:0000313|EnsemblPlants:PGSC0003DMT400012963};
OS Solanum tuberosum (Potato).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX NCBI_TaxID=4113 {ECO:0000313|EnsemblPlants:PGSC0003DMT400012963, ECO:0000313|Proteomes:UP000011115};
RN [1] {ECO:0000313|Proteomes:UP000011115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DM1-3 516 R44 {ECO:0000313|Proteomes:UP000011115};
RX PubMed=21743474; DOI=10.1038/nature10158;
RG The Potato Genome Sequencing Consortium;
RT "Genome sequence and analysis of the tuber crop potato.";
RL Nature 475:189-195(2011).
RN [2] {ECO:0000313|EnsemblPlants:PGSC0003DMT400012963}
RP IDENTIFICATION.
RC STRAIN=DM1-3 516 R44 {ECO:0000313|EnsemblPlants:PGSC0003DMT400012963};
RG EnsemblPlants;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_006343286.1; XM_006343224.2.
DR RefSeq; XP_006343287.1; XM_006343225.2.
DR RefSeq; XP_015162422.1; XM_015306936.1.
DR RefSeq; XP_015162423.1; XM_015306937.1.
DR RefSeq; XP_015162424.1; XM_015306938.1.
DR RefSeq; XP_015162425.1; XM_015306939.1.
DR RefSeq; XP_015162426.1; XM_015306940.1.
DR AlphaFoldDB; M1A232; -.
DR SMR; M1A232; -.
DR PaxDb; 4113-PGSC0003DMT400012963; -.
DR EnsemblPlants; PGSC0003DMT400012963; PGSC0003DMT400012963; PGSC0003DMG400005052.
DR GeneID; 102588652; -.
DR Gramene; PGSC0003DMT400012963; PGSC0003DMT400012963; PGSC0003DMG400005052.
DR KEGG; sot:102588652; -.
DR eggNOG; KOG4658; Eukaryota.
DR HOGENOM; CLU_000837_8_8_1; -.
DR InParanoid; M1A232; -.
DR OMA; RRIGCIS; -.
DR OrthoDB; 1216134at2759; -.
DR Proteomes; UP000011115; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0050832; P:defense response to fungus; IEA:InterPro.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039203; RGA2/3-like.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR36766:SF33; DISEASE RESISTANCE RPP13-LIKE PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR36766; PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00369; LRR_TYP; 4.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000011115};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 5..93
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 167..406
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
SQ SEQUENCE 1139 AA; 130124 MW; F420DFDE0E83A451 CRC64;
MAEAFVEVLL QNLSSFIQKE LGLFYGVDEE LRKLSSLLST IKAVLQDADQ EQLKEKAIRN
WLQKLNCATY EVDDVLDECA AKAIRLQEKS RRIGCISMPS GFTLENLLFR RQIGKKVKDA
IRKLDGIAEE RLKFHLSEVT SKKRLSTTDE VRETGFVLTS AEVYGRDNDK RKIVEILTKH
VDDFQELLVL PIVGMGGLGK TTLAQLIYND VLVHEHFDLK IWVCVSHNFD EKRLIRAILE
AIVGKDINAS ELASLQSQLI NLLRGKRYLL ILDDVWNEDQ EKWDKLKALL TIGSRGTSVI
TTTRLEKVAS IMGTVQPHRL SCLSEYDCWL LFKQRAFGLD RKESSKLVDI GKEIVRRCCG
VPLAAKALGS LLRFKNDEKE WLFVRDSDFW NLPQDESSIL PALRLSYFHL PQDLRHCFAY
CAIFEKGSKI DKEELIYFWM ANGFISSEGN LEPEDKGNEV WNELYWRSLF QEVQQTSDGK
MLFKIHDLVH DLAQSIMDDG IHATKLEGGE KISTSRIRHA TIHAEDKSFL AFPKSTMPYN
PSTIAMYGSL RVLIFCSVQL KELPSAIGNL IHLRYLDLFS TCVESLPQSI CSLQNLQMLS
VEDCCLLRVL PKHLNYLRNL RHLRLRGCPL SHMPPNIAQL THLKTLNKFV VGKKRCSKLS
ELRDLNLQGE LVIEHLERVE NHMGAKEALI SKRNLHSLAL YWNHSVRCES SKDVDLQVLE
ALEPHSDLKH LKVSGFKSTC LASWMRASVL RTIITLYLHD CKYCLHLSQL AQLPCLKYLS
LRGIHVEYID NDVESGVSQL RKFPSLESLE MCKLPNLKGV SIEEGEEQFP SLHEMWIENC
PLLTFPCLVT LRNLRIMKCS NMTLASISNL CGLTCLEIAN NKELTSFPEE VLTNLTDLEI
LTIMDFSKLE VLPNNLASLT ALKSLDIGYC HQLESLPEQG LQGLTSVRKL SVRCSDRLKY
LSEGFRHLAS LEELEIFGCP KLVSFPQEIK HLNSLHRVHL DGLPLFHSRE DTVIHPEELG
FWQLPEALRH VHNLQSLSVC RFSSLTLLPE WLGELTFLKE LNIVQCDNLA SLPECMERMN
LQSLNILGCA ILEKRCKPGQ GEDWYKIEHI PKVKISQNCD FLSINLSSER FSGLRRFHL
//
