ID   M1ADC1_SOLTU            Unreviewed;       441 AA.
AC   M1ADC1;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   27-MAR-2024, entry version 52.
DE   SubName: Full=RGC1 {ECO:0000313|EnsemblPlants:PGSC0003DMT400020346};
OS   Solanum tuberosum (Potato).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX   NCBI_TaxID=4113 {ECO:0000313|EnsemblPlants:PGSC0003DMT400020346, ECO:0000313|Proteomes:UP000011115};
RN   [1] {ECO:0000313|Proteomes:UP000011115}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. DM1-3 516 R44 {ECO:0000313|Proteomes:UP000011115};
RX   PubMed=21743474; DOI=10.1038/nature10158;
RG   The Potato Genome Sequencing Consortium;
RT   "Genome sequence and analysis of the tuber crop potato.";
RL   Nature 475:189-195(2011).
RN   [2] {ECO:0000313|EnsemblPlants:PGSC0003DMT400020346}
RP   IDENTIFICATION.
RC   STRAIN=DM1-3 516 R44 {ECO:0000313|EnsemblPlants:PGSC0003DMT400020346};
RG   EnsemblPlants;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- FUNCTION: Confers resistance to late blight (Phytophthora infestans)
CC       races carrying the avirulence gene Avr1. Resistance proteins guard the
CC       plant against pathogens that contain an appropriate avirulence protein
CC       via an indirect interaction with this avirulence protein. That triggers
CC       a defense system including the hypersensitive response, which restricts
CC       the pathogen growth. {ECO:0000256|ARBA:ARBA00002074}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC       Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC   -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC       {ECO:0000256|ARBA:ARBA00008894}.
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DR   AlphaFoldDB; M1ADC1; -.
DR   PaxDb; 4113-PGSC0003DMT400020346; -.
DR   EnsemblPlants; PGSC0003DMT400020346; PGSC0003DMT400020346; PGSC0003DMG400007869.
DR   Gramene; PGSC0003DMT400020346; PGSC0003DMT400020346; PGSC0003DMG400007869.
DR   eggNOG; KOG4658; Eukaryota.
DR   InParanoid; M1ADC1; -.
DR   OMA; ISIHKTH; -.
DR   Proteomes; UP000011115; Unassembled WGS sequence.
DR   ExpressionAtlas; M1ADC1; baseline.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0098542; P:defense response to other organism; IEA:UniProt.
DR   Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR042197; Apaf_helical.
DR   InterPro; IPR044974; Disease_R_plants.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR   PANTHER; PTHR23155:SF1235; DISEASE RESISTANCE RPP13-LIKE PROTEIN 1; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Hypersensitive response {ECO:0000256|ARBA:ARBA00022667};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011115}.
FT   DOMAIN          4..87
FT                   /note="NB-ARC"
FT                   /evidence="ECO:0000259|Pfam:PF00931"
FT   REGION          421..441
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   441 AA;  51026 MW;  0967C53A044DEFB3 CRC64;
     MNFDESWNLL HKKIFEKEGS YSPEFENIGK QIALKCGGLP LEITLIAGLL SKISKTLDEW
     QNVAENVSSV VSRDLEAKCM RVLALSYHHL PSHLKPCFLY FAIFAEDERI YVNALVELWA
     VEGFLNEEEG KSIEEVAETC INELVDRSLI SIHNLSFDGE IERCGMHDVI RELCLREARN
     MNFVNVIRGK SDQNSCAQSM QCSFKSRSRI SIYKKEELAW CRNSEAHSII MLGGLKCFTL
     ELSFKLVRVL DLGLNIYPIF PSGVLSLIHL RYLSLCFYPC LKQYRGSLKA VPSSIIDIPL
     SISSLCYLQT FKFNFPFRDC AYPFILPSEI LTMPQLRKLC MGWNYLQSHE PTENRLVLKS
     LQCLNQLNPW YCTGSFFRLF PNLKKLKVFG VPEDFRNHKD LYDFRYLYQL EKLVFDTVTT
     DEDDDDDDFE KEVASCRNND K
//