ID M1AFF9_SOLTU Unreviewed; 1018 AA.
AC M1AFF9;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Cc-nbs-lrr resistance protein {ECO:0000313|EnsemblPlants:PGSC0003DMT400021631};
GN Name=107061281 {ECO:0000313|EnsemblPlants:PGSC0003DMT400021631};
OS Solanum tuberosum (Potato).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX NCBI_TaxID=4113 {ECO:0000313|EnsemblPlants:PGSC0003DMT400021631, ECO:0000313|Proteomes:UP000011115};
RN [1] {ECO:0000313|Proteomes:UP000011115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DM1-3 516 R44 {ECO:0000313|Proteomes:UP000011115};
RX PubMed=21743474; DOI=10.1038/nature10158;
RG The Potato Genome Sequencing Consortium;
RT "Genome sequence and analysis of the tuber crop potato.";
RL Nature 475:189-195(2011).
RN [2] {ECO:0000313|EnsemblPlants:PGSC0003DMT400021631}
RP IDENTIFICATION.
RC STRAIN=DM1-3 516 R44 {ECO:0000313|EnsemblPlants:PGSC0003DMT400021631};
RG EnsemblPlants;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- FUNCTION: Confers resistance to late blight (Phytophthora infestans)
CC races carrying the avirulence gene Avr1. Resistance proteins guard the
CC plant against pathogens that contain an appropriate avirulence protein
CC via an indirect interaction with this avirulence protein. That triggers
CC a defense system including the hypersensitive response, which restricts
CC the pathogen growth. {ECO:0000256|ARBA:ARBA00002074}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
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DR RefSeq; XP_015165770.1; XM_015310284.1.
DR AlphaFoldDB; M1AFF9; -.
DR PaxDb; 4113-PGSC0003DMT400021631; -.
DR EnsemblPlants; PGSC0003DMT400021631; PGSC0003DMT400021631; PGSC0003DMG400008393.
DR GeneID; 107061281; -.
DR Gramene; PGSC0003DMT400021631; PGSC0003DMT400021631; PGSC0003DMG400008393.
DR KEGG; sot:107061281; -.
DR eggNOG; KOG4658; Eukaryota.
DR HOGENOM; CLU_000837_8_8_1; -.
DR InParanoid; M1AFF9; -.
DR OMA; LSIEYCR; -.
DR OrthoDB; 781296at2759; -.
DR Proteomes; UP000011115; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0098542; P:defense response to other organism; IEA:UniProt.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1235; DISEASE RESISTANCE RPP13-LIKE PROTEIN 1; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hypersensitive response {ECO:0000256|ARBA:ARBA00022667};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000011115}.
FT DOMAIN 10..97
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 168..411
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT COILED 112..139
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1018 AA; 116864 MW; 8AD1D8DBCA05FCAD CRC64;
MADSVIGATV QVLLEKLLSL TIEEFSSSRD CNKELEMLTQ NVSLIQAFIH DAERRQVDDQ
AVKLWLNRLE RAAENAEYVF DKFRYESLKR QVKIRNNPMR KVSDFFSHSA FKNKMSRKIN
NINEELRAIN KVAKNLGLQS LMVPPRKILP IRETDSIVVP SDVVGRDNDV AEIKRKMLNI
RDDVVLCTIP IVGMGGLGKT TLAKRIFNDE QIEKHFEKRV WLCLPEMSEI KSFLELILEA
LTERKLEVQS RDIIVKKVRD ELAGRKYLIV LDDLWRVDPT LWDEFVDTLR GINTSRGNFI
LVTTRMELVA STVAAVLGPH MLEKLAEDHC WSIFKQRAFV DGKIPEEIVS MEKRIVEMCQ
GLPLAASVMG GLLRSKEKDE WQAILDGNPL VAGENDNGEK SIKKILKLSY DYLPSPQLKK
CFAYFAMFPK DFEFEKEQLI QLWMAEGFLH PCQETTVMED VGHRFFQILL KNSLLQDVEL
HEHNNIRHCK MHDLVHDLAG DILKSKLFDP TGDDGEKLSL VRYFGCESPM DQIDKIYEPE
RLCTLFWRNN YIWEDILLSF KFMRVLDLSS SGIRELSAKI GKLIYLRYLD LSDTKITALP
NSICELYNLQ TFRVINCFSL KELPYEMRNM ISLRHIYYTS VDRTQYWGGW CIRNEHFQMP
LNMGQLTSLQ TLQFFKVGLE KGRQIEELGH LKNLRGELTI NGLQLICDKE EARTTYLQEK
PNICKLAYLW THDESEGCEI NDEYVLDGLQ PHPNLKTLAV VGYLGTKFPS WFSEESLPNL
VKLKLSGSKR CKEIPSLGQL KVLQHLELVG FHELECIGPA LYGVEISNIG SSSIIQVFPS
LKELVLEDMR SLIEWKGDEV GVKMSPGLEK LRITDCPLLK STPTQFEILR QLEIRGVDSE
MPLLNLCSNL TSLVDLYVSN VKELTCLPDE MLRNNVSLQY LSVIDCGEFR ELPQSLYNLH
SLKRLMIDSC TNFSSLPVPN GDNYLTSLQL LLLCNCDGLI SLPIGMLDQC QSLVFLNE
//
