ID M1AFG2_SOLTU Unreviewed; 1273 AA.
AC M1AFG2;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Cc-nbs-lrr resistance protein {ECO:0000313|EnsemblPlants:PGSC0003DMT400021634};
OS Solanum tuberosum (Potato).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX NCBI_TaxID=4113 {ECO:0000313|EnsemblPlants:PGSC0003DMT400021634, ECO:0000313|Proteomes:UP000011115};
RN [1] {ECO:0000313|Proteomes:UP000011115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DM1-3 516 R44 {ECO:0000313|Proteomes:UP000011115};
RX PubMed=21743474; DOI=10.1038/nature10158;
RG The Potato Genome Sequencing Consortium;
RT "Genome sequence and analysis of the tuber crop potato.";
RL Nature 475:189-195(2011).
RN [2] {ECO:0000313|EnsemblPlants:PGSC0003DMT400021634}
RP IDENTIFICATION.
RC STRAIN=DM1-3 516 R44 {ECO:0000313|EnsemblPlants:PGSC0003DMT400021634};
RG EnsemblPlants;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- FUNCTION: Confers resistance to late blight (Phytophthora infestans)
CC races carrying the avirulence gene Avr1. Resistance proteins guard the
CC plant against pathogens that contain an appropriate avirulence protein
CC via an indirect interaction with this avirulence protein. That triggers
CC a defense system including the hypersensitive response, which restricts
CC the pathogen growth. {ECO:0000256|ARBA:ARBA00002074}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; M1AFG2; -.
DR PaxDb; 4113-PGSC0003DMT400021634; -.
DR EnsemblPlants; PGSC0003DMT400021634; PGSC0003DMT400021634; PGSC0003DMG400008394.
DR Gramene; PGSC0003DMT400021634; PGSC0003DMT400021634; PGSC0003DMG400008394.
DR eggNOG; KOG4658; Eukaryota.
DR InParanoid; M1AFG2; -.
DR OMA; HNTITHY; -.
DR Proteomes; UP000011115; Unassembled WGS sequence.
DR ExpressionAtlas; M1AFG2; baseline.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0098542; P:defense response to other organism; IEA:UniProt.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1235; DISEASE RESISTANCE RPP13-LIKE PROTEIN 1; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hypersensitive response {ECO:0000256|ARBA:ARBA00022667};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000011115}.
FT DOMAIN 10..95
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 168..409
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
SQ SEQUENCE 1273 AA; 145840 MW; 74D82D48AF595B22 CRC64;
MADPVIGATV QVLLEKLISL TIEEVNSSRD FNKDLEMLTQ NVSLIQAFIH DVETPQVEKQ
QSIEQWLNRL ERVAEDAENV FDRFRYESLK TKVVRSPLKK VSGFFSHTAF KRKMSQKINN
INKELTAINK VAKDLGLQSL MVPFRKILPI RETDSLVVAS DIVGRDLDVA EIKEKILNMR
EEDIVLSTIP IVGMGGLGKT TVAKRIYNDE HIQQIFEKRI WLCLPEMSET KCFLEQILES
LIERRIEVER RDIIVKKLQD ELRGKKYLLV LDDLWCVDST SWHEFVDTLR GINTSRGNCI
LVTTRMKRVA STVATDLHIL GKLTEDHCWS IFKQKAFVDG RVPEELASMG NKIVKMCQGL
PLAASALGGL LHNKEKHEWQ AILDGSLLVA GEDDNGENSI KKILKLSYDY LPSPHLKKCF
AYFAMFPKDY MFEKDQLIQL WMAEGFLRPS QEIPVMEDVG HRFFQILLQN SLLQDVVLDE
HNTITHYKMH DLVHDLAGDI LKSRLFDPKG DNGEKLSQVR YFGCESPTDQ IDKIYEPERL
CTLFWRSNYT SKDMLLNFKF LRVLDLSSSG IKELSAKMGK LIYLRYLDLS NTEITALPNS
ICELYNLQTF RVINCFSLQK LPYEMRNMIS LRHIYYTSVD ETSGHWGGWC LHNEHFQIPL
NMGQLTSLQT LKFFKVGLEK GRQIEELGHL KNLRGELTIN GLQLVCDKEE ARTAYLHDKP
NICKLAYLWS HDESEGCEIN DEHVLDGLQP HPNLKTLAVV DYLGTKFPSW FSEESLPNLV
KLKLSGSKRC KEIPSLGQLK FLRHLELIGF HELECIGPAL DGVEIRNIGS NSIIQVFPSL
KELVLEDMRS LIEWKGDEVG VRMSPRLEKL RITDCPLLKS IPNQFEILRQ LEIRGVDSEM
PLLNLCSNLT SLVKLSVYDM KELTCLPDEI LRNNVSLQQI TIFNCGEFRE LPQSLYNLHS
LKRLDIYNCT NFSSLPVPNG DNYLTSLEFF FLYNCNGLIS LPIGMLDQCR SLEFLCVSCC
NNLVSFPLHV WEMPSFSFLD ITECPKLISV PKVGLHHLTG LLRLGIGPFS EMVDFDAFQL
IFNGIQQLLS LRDLEVYGRG HWDSLPYQIM QLSDLREITI ADFGIEALPP RLDNLTSLES
LTLVRCKQLQ HLNFSDAMPK LRLLCISDCP LLEALSDGLG NLVSLEELYL HDCEKLEHLP
SRDAMRRLTK LWNMGIKGCP KLEESFTNYS QWSKISHISN IELGGRRRTT LVQNVSVVNQ
AKSYEQQAIT LGY
//