ID M1AFY1_SOLTU Unreviewed; 326 AA.
AC M1AFY1;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Metaxin {ECO:0000256|PIRNR:PIRNR038150};
GN Name=102592956 {ECO:0000313|EnsemblPlants:PGSC0003DMT400021961};
OS Solanum tuberosum (Potato).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX NCBI_TaxID=4113 {ECO:0000313|EnsemblPlants:PGSC0003DMT400021961, ECO:0000313|Proteomes:UP000011115};
RN [1] {ECO:0000313|Proteomes:UP000011115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DM1-3 516 R44 {ECO:0000313|Proteomes:UP000011115};
RX PubMed=21743474; DOI=10.1038/nature10158;
RG The Potato Genome Sequencing Consortium;
RT "Genome sequence and analysis of the tuber crop potato.";
RL Nature 475:189-195(2011).
RN [2] {ECO:0000313|EnsemblPlants:PGSC0003DMT400021961}
RP IDENTIFICATION.
RC STRAIN=DM1-3 516 R44 {ECO:0000313|EnsemblPlants:PGSC0003DMT400021961};
RG EnsemblPlants;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- FUNCTION: Involved in transport of proteins into the mitochondrion.
CC {ECO:0000256|PIRNR:PIRNR038150}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC {ECO:0000256|PIRNR:PIRNR038150}.
CC -!- SIMILARITY: Belongs to the metaxin family.
CC {ECO:0000256|PIRNR:PIRNR038150}.
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DR RefSeq; XP_006359063.1; XM_006359001.2.
DR AlphaFoldDB; M1AFY1; -.
DR STRING; 4113.M1AFY1; -.
DR PaxDb; 4113-PGSC0003DMT400021961; -.
DR EnsemblPlants; PGSC0003DMT400021961; PGSC0003DMT400021961; PGSC0003DMG400008514.
DR GeneID; 102592956; -.
DR Gramene; PGSC0003DMT400021961; PGSC0003DMT400021961; PGSC0003DMG400008514.
DR KEGG; sot:102592956; -.
DR eggNOG; KOG3028; Eukaryota.
DR HOGENOM; CLU_071432_0_0_1; -.
DR InParanoid; M1AFY1; -.
DR OMA; YFQTRCL; -.
DR OrthoDB; 1030843at2759; -.
DR Proteomes; UP000011115; Unassembled WGS sequence.
DR ExpressionAtlas; M1AFY1; baseline.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005741; C:mitochondrial outer membrane; IBA:GO_Central.
DR GO; GO:0001401; C:SAM complex; IEA:InterPro.
DR GO; GO:0007005; P:mitochondrion organization; IEA:InterPro.
DR GO; GO:0006626; P:protein targeting to mitochondrion; IBA:GO_Central.
DR CDD; cd03193; GST_C_Metaxin; 1.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR017410; Metaxin1/3.
DR InterPro; IPR033468; Metaxin_GST.
DR InterPro; IPR012336; Thioredoxin-like_fold.
DR PANTHER; PTHR12289; METAXIN RELATED; 1.
DR PANTHER; PTHR12289:SF41; METAXIN-1 HOMOLOG; 1.
DR Pfam; PF17171; GST_C_6; 1.
DR Pfam; PF17172; GST_N_4; 1.
DR PIRSF; PIRSF038150; Metaxin; 1.
DR SUPFAM; SSF47616; GST C-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00022787,
KW ECO:0000256|PIRNR:PIRNR038150};
KW Reference proteome {ECO:0000313|Proteomes:UP000011115};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 290..308
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 26..120
FT /note="Thioredoxin-like fold"
FT /evidence="ECO:0000259|Pfam:PF17172"
FT DOMAIN 170..232
FT /note="Metaxin glutathione S-transferase"
FT /evidence="ECO:0000259|Pfam:PF17171"
FT REGION 238..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..266
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 269..283
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 326 AA; 36740 MW; 1AE78F1BFCE248E6 CRC64;
MEEAKEREKL TLVTRKSCFG LPTSCPNCLP AYVYLKFSGT PFDLDFNLIN PDSDQIPYVE
SGTYVAYNNE KGGVIRSLSE DGFVDLDSQV RGIPEWISAK AMVDSWLADA IIYELWVGSD
GTSAHKIYYS DLPWPLGKIL YLKQVHVVKQ ILGITKENAE RREEEIYRNA NDAFCALSTR
LGEQAYFFDN RPTSLDAVFL GHALFTLYAL PETSVLRSKL LEHDNLVRYT EKYKSELVDS
SGSSSSGSQS QSDPSSSMPR RPSQWSSKPK SKPKREKTEE EKKFRRRAKY FLVTQLVAVL
VFLSLLGGSD AAEVELDEDD DGADYD
//
