ID M1ALU2_SOLTU Unreviewed; 931 AA.
AC M1ALU2;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Glutamate receptor {ECO:0000256|PIRNR:PIRNR037090};
OS Solanum tuberosum (Potato).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX NCBI_TaxID=4113 {ECO:0000313|EnsemblPlants:PGSC0003DMT400025675, ECO:0000313|Proteomes:UP000011115};
RN [1] {ECO:0000313|Proteomes:UP000011115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DM1-3 516 R44 {ECO:0000313|Proteomes:UP000011115};
RX PubMed=21743474; DOI=10.1038/nature10158;
RG The Potato Genome Sequencing Consortium;
RT "Genome sequence and analysis of the tuber crop potato.";
RL Nature 475:189-195(2011).
RN [2] {ECO:0000313|EnsemblPlants:PGSC0003DMT400025675}
RP IDENTIFICATION.
RC STRAIN=DM1-3 516 R44 {ECO:0000313|EnsemblPlants:PGSC0003DMT400025675};
RG EnsemblPlants;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- FUNCTION: Glutamate-gated receptor that probably acts as non-selective
CC cation channel. {ECO:0000256|PIRNR:PIRNR037090}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|ARBA:ARBA00008685, ECO:0000256|PIRNR:PIRNR037090}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; M1ALU2; -.
DR STRING; 4113.M1ALU2; -.
DR PaxDb; 4113-PGSC0003DMT400025675; -.
DR EnsemblPlants; PGSC0003DMT400025675; PGSC0003DMT400025675; PGSC0003DMG400009914.
DR Gramene; PGSC0003DMT400025675; PGSC0003DMT400025675; PGSC0003DMG400009914.
DR eggNOG; KOG1052; Eukaryota.
DR HOGENOM; CLU_007358_0_1_1; -.
DR InParanoid; M1ALU2; -.
DR OMA; TMDMELF; -.
DR Proteomes; UP000011115; Unassembled WGS sequence.
DR ExpressionAtlas; M1ALU2; baseline.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IBA:GO_Central.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR CDD; cd13686; GluR_Plant; 1.
DR CDD; cd19990; PBP1_GABAb_receptor_plant; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 3.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR044440; GABAb_receptor_plant_PBP1.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR017103; Iontropic_Glu_rcpt_pln.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR18966:SF422; KAINATE-TYPE IONOTROPIC GLUTAMATE RECEPTOR SUBUNIT 1D; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR Pfam; PF00497; SBP_bac_3; 1.
DR PIRSF; PIRSF037090; Iontro_Glu-like_rcpt_pln; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR037090-50};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|PIRNR:PIRNR037090};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|PIRNR:PIRNR037090};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW ECO:0000256|PIRNR:PIRNR037090};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR037090};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR037090};
KW Reference proteome {ECO:0000313|Proteomes:UP000011115};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR037090}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..931
FT /note="Glutamate receptor"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004012807"
FT TRANSMEM 590..608
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 650..674
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 829..849
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 469..809
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT REGION 888..931
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 888..919
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 758..812
FT /evidence="ECO:0000256|PIRSR:PIRSR037090-50"
SQ SEQUENCE 931 AA; 102988 MW; AA6D68553480BFE6 CRC64;
MNVVWIIVSC IVCFGVCSDG LSGNGTSRPA VVNVGAIFTF DSTIGRAAKI AIQEAVKDVN
SNSSVLQGTK LVVQLQNSNC SGFLGMVGAL KFMETDVVAV IGPQSSVVAH TISHVANELQ
VPFLSFAATD PTLSCLQFPY FLRTTQSDLY QMTAIAEIIE FYAWKEVIAI FIDDDYGRNG
VSALDEALAT RRCRISYKAG ISPGATVTRG DVMDVMVKVA LMESRVIVLH AYRTLGLMVL
SVAHYLGMMG DGYVWISTDW LTTVLDSSPP LLQDTMDTMQ GVLVLRQHTP DSENKRAFSS
RWNKLTGGLL GLNSYALHAY DTVWLAAHAI DSFFNQGGTI SFSNDTKLQS VEGSNLHLEA
MSIFDGGPLL LKNLLESDFV GLTGPFKFSP DKSLIRPAYD IINVIGTGFR RVGYWSNYSG
LSILPPETFY SRPPNRSSTN QKLYSVVWPG NNVQKPRGWV FPNNGKQLKI GVPIRVSYRE
FVSQSPGTNN FKGFCIDVFT AAVNLLPYAV PHKFVPYGNG HENPSYTDMV RLITTGKFDG
VVGDVAIVTN RTRVVDFTQP YAASGLVVVA PFQKLNSGGW AFLRPFSAQM WGVITIFFLF
VGMVVWILEH RTNDEFRGPP KQQLITILWF SLSTLFFAHR ENTVSTLGRM VLIIWLFVVL
IINSSYTASL TSILTVQQLY SPIKGIESLK ETDEPIGYQV GSFAERYLEE IGIPKSRLVP
LGSPEEYATA LQRGPAKGGV SAVVDERPYV ELFLSNQCKF RIVGQEFTKS GWGFAFPRDS
PLAVDLSTAI LTLSENGDLQ RIHDKWLARS ACSLDNAELE SDRLHLRSFS GLFLICGIAC
FIALLIYFIQ ILRKFCQTSN AAVDMDGQST TSRSKRLQTL LSIIDEKSDK SNRGSKRRKI
DRSVSADNIE NDLGRDSRWR ESQVPSQNEI H
//
