ID M1B044_SOLTU Unreviewed; 1173 AA.
AC M1B044;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=TMV resistance protein N {ECO:0000313|EnsemblPlants:PGSC0003DMT400034091};
OS Solanum tuberosum (Potato).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX NCBI_TaxID=4113 {ECO:0000313|EnsemblPlants:PGSC0003DMT400034091, ECO:0000313|Proteomes:UP000011115};
RN [1] {ECO:0000313|Proteomes:UP000011115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DM1-3 516 R44 {ECO:0000313|Proteomes:UP000011115};
RX PubMed=21743474; DOI=10.1038/nature10158;
RG The Potato Genome Sequencing Consortium;
RT "Genome sequence and analysis of the tuber crop potato.";
RL Nature 475:189-195(2011).
RN [2] {ECO:0000313|EnsemblPlants:PGSC0003DMT400034091}
RP IDENTIFICATION.
RC STRAIN=DM1-3 516 R44 {ECO:0000313|EnsemblPlants:PGSC0003DMT400034091};
RG EnsemblPlants;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
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DR AlphaFoldDB; M1B044; -.
DR EnsemblPlants; PGSC0003DMT400034091; PGSC0003DMT400034091; PGSC0003DMG400013098.
DR Gramene; PGSC0003DMT400034091; PGSC0003DMT400034091; PGSC0003DMG400013098.
DR HOGENOM; CLU_001561_1_1_1; -.
DR Proteomes; UP000011115; Unassembled WGS sequence.
DR ExpressionAtlas; M1B044; baseline.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0098542; P:defense response to other organism; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR11017:SF236; TMV RESISTANCE PROTEIN N-LIKE; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000011115}.
FT DOMAIN 13..187
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1173 AA; 133423 MW; F151EBFF86919DA2 CRC64;
MRVEKASVSR PRCSYHVYLS YRGKEISVNF INILHTALTD VGIQTFKRHS EARKGKIVGS
ELQKAVKESR ISIIVFTEDY GYSRRCLDEL VNILERKQSA GHMILPVFYR VDPSHIRKQR
ESYAKAFHNY EEQIMAKKVE RRNEHIAKIK IWRSSLTEVA NMAGIVLEDG DELKFIQEIV
EDIWGKLSRK VLSFAPYPVG IYSRVKEINF WLQDSSTNSR TLMIYGEPGI GKTTIAKALF
NLHCDRFQCS RFLGDIREIA KESCGLINLQ KNLLSDLLKE DKIDLNDIDR GASTIKECLV
HKKFLLVLDD VDDLNQLKGL LDSREWIPPG SKVIITTTNE HLLNPLDACV MYETKRMNNY
EALKLFSLHT FGQDHPVKEY MKHSKQIVKH CRGLPLALQV LASSLRGGSI DMWEGAIQKL
ERYSECHNHK VLELSYEALP DDHDKNVFLD IACFFVGKDK DYTIKVLDEC GFHATAEIQN
LIDRYLLTVT PDNKLMMHQL LQEMGKEVIC RESPIEPGKR SRIWHHKDAL SILHEETVTE
SIEGLVLKMC GSDESKPDRH ESISKRPYFN DSQSTSTLTL KKNSSKRLRV GCLSWGLGNS
VLARSQTVQN EAGMSAKAFS KMQELRYLEL ENVQLSGTFE GFPKKLRWMR WYGRFQSTSF
PNGFPHENLV VLEMNNSNLH QTWEGAKSLR SLKILDLGHS HSLMKTPDFS GMPNLERVIL
EDCINLVKVH ESIGRLHKLL VLNLKGCESL KKLPRKIWEI KSLQELTLCG CSKLELSRIM
RNGKFLQALT RDVTNRDQFS SKAEKPICSD SLSAKSVYSI FWSWMSLWPK SAGSMSDIFQ
ITLQSLDISH SNLTDTLIPY DLSVLSSLKY LSLRGNPIST LPESLKSLTM LQSLQLADCT
RLQWIPELPL SLQILNASNC RSLNKVTNLP NFMRSLDLHL ENCEKLVEVQ GVFKLDPIRD
IDDILDMSCL DNLEVRAVDV ELCNYLSSTK SKGPLQGLYE FGIHNIYIPG VKVPTEFSNI
STGSSIDFTV PPLPNAKIQG LKICVAYAEC LEECFSERHF IKVSNKTKGI KWIYGPTIFG
IAGPGNPMLW FSHWKFGNQL ERGDQVVVSV SMGCLVKKFG VYLVCSEQSE EEEDTLSNAE
GCRRLSYPLQ HAIGGDLSPY ELSSGVYHLS IYS
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