ID M1B1S4_SOLTU Unreviewed; 2060 AA.
AC M1B1S4;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Disease resistance protein {ECO:0000313|EnsemblPlants:PGSC0003DMT400035068};
OS Solanum tuberosum (Potato).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX NCBI_TaxID=4113 {ECO:0000313|EnsemblPlants:PGSC0003DMT400035068, ECO:0000313|Proteomes:UP000011115};
RN [1] {ECO:0000313|Proteomes:UP000011115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DM1-3 516 R44 {ECO:0000313|Proteomes:UP000011115};
RX PubMed=21743474; DOI=10.1038/nature10158;
RG The Potato Genome Sequencing Consortium;
RT "Genome sequence and analysis of the tuber crop potato.";
RL Nature 475:189-195(2011).
RN [2] {ECO:0000313|EnsemblPlants:PGSC0003DMT400035068}
RP IDENTIFICATION.
RC STRAIN=DM1-3 516 R44 {ECO:0000313|EnsemblPlants:PGSC0003DMT400035068};
RG EnsemblPlants;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- FUNCTION: Confers resistance to late blight (Phytophthora infestans)
CC races carrying the avirulence gene Avr1. Resistance proteins guard the
CC plant against pathogens that contain an appropriate avirulence protein
CC via an indirect interaction with this avirulence protein. That triggers
CC a defense system including the hypersensitive response, which restricts
CC the pathogen growth. {ECO:0000256|ARBA:ARBA00002074}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
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DR PaxDb; 4113-PGSC0003DMT400035068; -.
DR EnsemblPlants; PGSC0003DMT400035068; PGSC0003DMT400035068; PGSC0003DMG400013486.
DR Gramene; PGSC0003DMT400035068; PGSC0003DMT400035068; PGSC0003DMG400013486.
DR eggNOG; KOG4658; Eukaryota.
DR HOGENOM; CLU_000760_0_0_1; -.
DR InParanoid; M1B1S4; -.
DR OMA; YPLNFLP; -.
DR Proteomes; UP000011115; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0098542; P:defense response to other organism; IEA:UniProt.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1235; DISEASE RESISTANCE RPP13-LIKE PROTEIN 1; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hypersensitive response {ECO:0000256|ARBA:ARBA00022667};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000011115}.
FT DOMAIN 1171..1249
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 1313..1552
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
SQ SEQUENCE 2060 AA; 235907 MW; F0A6543441C3C38E CRC64;
MAEDSCFILK KSISDCVKTG QLDSSAKDQL DYARAIVDNL WYYFGWLKKE NCKNMVSAQL
KPLIDEANDG FCEIHSLLKN QGLTSETVKM ISEVMKMIKP EIIAERFISP SKQSTSSSTR
MITMDMVNVV TSICHTVEYL TKITFREFKH LGVLLKFTAK RCNIEHEKIK DLFTLAEDIA
KTATYLSILC WETYDQYSAR ISAPKSSIWV TYNVFAGPDF ESKISKLLER INPIRPEWRK
LYISFLKASH SSAPLMHGGL KNLSHDLDLD LAQKFTESIR YDLEKLKSHD ASLNVAFSNR
FEWLQDGLLH LSEFHKILDR QRQDLSSLLS FLEVLAIEAA IAIYCLCDID LENNIAEVDL
IFLPLQMKFK YLKVEISLFQ KLRLPESQVD CFQEELTSMK TFLMDSLDKC KVQTQLTDVL
TLVLSVTTEA ESFTNSLSRD SEDGALARKI NLLHFQLHLK FKFIREAICP FISASSTPVL
PVIYPLNFLP TYVEAISSYF TMLKSSKTSP SAGSPTMDEV FMEFHEYIFE NLLLKVEADL
ELTDTDKVKR FYHRLMPLVT LVVDPPMQYI ECKRQNDLLR KIGTLAIEAE AAIRLSYEDA
LDRSKSREVG LLLQLLAASF MLIKCEGKLM DQLKHKAILE TEFLDLVANA HEEIIFLRGF
LMDLLRQHTT KLDKSDDLLM HAEVAAHKFS TCSYESFVDG SNTGKISDFL QETEFVEVDA
SHVLPLVLSV ATEAHSCITS LSRDSEEREL MSKINLLHFQ LLLKFKLIKA AIRQICPSFS
ASTPDHHVIY PLNFLPTYFE VIDSYFTKLK SSSDSPKMDE VLLRFHEYIF ENLLLKDEAD
LKLTDSDKLK RFYHSLLLFV SILVDPRIQY TECKKQNNLL SEIGALAIDA KAAIRLSYED
SSQSNRSKKV NLLLQLLTVA FMLIKCKGKL TDQLKHKAIL ETELLNLVEN ANEELIFLIV
FLIDLLGQQT IELNKSDGLL MHAEVAAHKS TLISTCSYEN FVDGSSSADM SLSLSDFLKE
TKSVNAEIRE VCFQLLDESA SYITVTDLKC LINMLLDMLN HLHSRGDVIP VVRNQIPVVQ
EKLEFLADIL KPCNMHTELK DLMERVQNVA YGEKYVIFFS VSGDSRAWFH QLYLYDVKQV
FNFVEAEVKT ITSEFHEVTG LNFPKTDGLG FLNCFLGKLE ELLHSKLDLI TKLKPQIVLV
KEELLILRSF FDHPEETYDE HDEICGLIIS ATEMAYKAEY VIDTCLACSY SQMYKAYWIS
EVVENIKLVN KDVGENLKRE EIDVNRVAKG STNIVPSLSA NTSGANEEMV GFQDVMDKLK
KQLLGGSHQL DVISIFGMPG NGKTTLAKKI YNDPTVVSHF DVRAMCHVTQ VYSWRDLLLT
ILNDVLEPAD RTKKGDDELA TELRRVLLTK RFLILIDDVW DKTAWDDLKM CFQGSQNRSR
IILTTRLYEV ADYAKCNSDP HPLRLLTDDE SWKLLQEELF HGQSFPCELG DVGLRIAKRC
GGLPLSIVLV AGVLKEKKKK ADCWKEVEES LSSHNIGSSE ESMSIIGFSY KNLPNHLKPC
FLYFGGFLRG KDIPVSKLSR VWLAEGIVED SKEKGSEDAA QDYLKDLIRK NLVTDMEKRS
NGKLKTCRVH DLLHQFCVEK AKQDNFLFWI HRYKKLYRFY SDNLHHNSHF HVFSLNSGHG
VDSISYPEKP EIYRLSIYSK WDDFAQWQQA GSSVRSLLFN ASSDDYYPAM AHNISFIINR
FKLVKVLNLE SINIGDTFPN ELKSLIHMRY FAVRTTADSI PSSVADLWNL ETFVVNGLHR
VLKLPCSLLK MFKLRHVHVN SRASFSLHDN MCESQLVNLE TFSTPCLSSG EDAEKILRSM
PNLRKLRCIV EGLLGYSTKG SIVRFPRLDF LHQLESLKLL SYSYPTKHPH EFNFPLNLRE
LTLSNFRLPW TQIWTVGKLP NLEILKLLFR AFEGNEWEVK DSDFPELKYL KLDNLNIAEW
SVMDDAFPKL EHLVLTKCKK LEKIPCHFGD VASLNIEVNW CSWSVANSAQ EFQTTQHEDM
ANYAFRVTIQ PPDWDTRSSH
//
