ID M1BC44_SOLTU Unreviewed; 531 AA.
AC M1BC44;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 59.
DE RecName: Full=Beta-hexosaminidase {ECO:0000256|PIRNR:PIRNR001093};
DE EC=3.2.1.52 {ECO:0000256|PIRNR:PIRNR001093};
GN Name=102599076 {ECO:0000313|EnsemblPlants:PGSC0003DMT400041850};
OS Solanum tuberosum (Potato).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX NCBI_TaxID=4113 {ECO:0000313|EnsemblPlants:PGSC0003DMT400041850, ECO:0000313|Proteomes:UP000011115};
RN [1] {ECO:0000313|Proteomes:UP000011115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DM1-3 516 R44 {ECO:0000313|Proteomes:UP000011115};
RX PubMed=21743474; DOI=10.1038/nature10158;
RG The Potato Genome Sequencing Consortium;
RT "Genome sequence and analysis of the tuber crop potato.";
RL Nature 475:189-195(2011).
RN [2] {ECO:0000313|EnsemblPlants:PGSC0003DMT400041850}
RP IDENTIFICATION.
RC STRAIN=DM1-3 516 R44 {ECO:0000313|EnsemblPlants:PGSC0003DMT400041850};
RG EnsemblPlants;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine
CC residues in N-acetyl-beta-D-hexosaminides.; EC=3.2.1.52;
CC Evidence={ECO:0000256|ARBA:ARBA00001231,
CC ECO:0000256|PIRNR:PIRNR001093};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 20 family.
CC {ECO:0000256|ARBA:ARBA00006285, ECO:0000256|PIRNR:PIRNR001093}.
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DR RefSeq; XP_006353240.1; XM_006353178.2.
DR RefSeq; XP_006353241.1; XM_006353179.2.
DR AlphaFoldDB; M1BC44; -.
DR STRING; 4113.M1BC44; -.
DR PaxDb; 4113-PGSC0003DMT400041850; -.
DR EnsemblPlants; PGSC0003DMT400041850; PGSC0003DMT400041850; PGSC0003DMG400016240.
DR GeneID; 102599076; -.
DR Gramene; PGSC0003DMT400041850; PGSC0003DMT400041850; PGSC0003DMG400016240.
DR KEGG; sot:102599076; -.
DR eggNOG; KOG2499; Eukaryota.
DR HOGENOM; CLU_007082_0_4_1; -.
DR InParanoid; M1BC44; -.
DR OMA; VVEVWPM; -.
DR OrthoDB; 178991at2759; -.
DR Proteomes; UP000011115; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0004563; F:beta-N-acetylhexosaminidase activity; IBA:GO_Central.
DR GO; GO:0102148; F:N-acetyl-beta-D-galactosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0030203; P:glycosaminoglycan metabolic process; IBA:GO_Central.
DR CDD; cd06562; GH20_HexA_HexB-like; 1.
DR Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR025705; Beta_hexosaminidase_sua/sub.
DR InterPro; IPR015883; Glyco_hydro_20_cat.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR029018; Hex-like_dom2.
DR InterPro; IPR029019; HEX_eukaryotic_N.
DR PANTHER; PTHR22600; BETA-HEXOSAMINIDASE; 1.
DR PANTHER; PTHR22600:SF21; BETA-HEXOSAMINIDASE A; 1.
DR Pfam; PF00728; Glyco_hydro_20; 1.
DR Pfam; PF14845; Glycohydro_20b2; 1.
DR PIRSF; PIRSF001093; B-hxosamndse_ab_euk; 1.
DR PRINTS; PR00738; GLHYDRLASE20.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF55545; beta-N-acetylhexosaminidase-like domain; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|PIRNR:PIRNR001093};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR001093};
KW Reference proteome {ECO:0000313|Proteomes:UP000011115};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..531
FT /note="Beta-hexosaminidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004012051"
FT DOMAIN 32..152
FT /note="Beta-hexosaminidase eukaryotic type N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14845"
FT DOMAIN 178..482
FT /note="Glycoside hydrolase family 20 catalytic"
FT /evidence="ECO:0000259|Pfam:PF00728"
FT ACT_SITE 325
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001093-1"
SQ SEQUENCE 531 AA; 59577 MW; 9C475F49B1A20D05 CRC64;
MGKFGLRSVL LFAVVVHILV ISVAADIKNL KIWPMPLSVS YGHRNLQLSN EFVLKTEGSK
YPDASGILKE GFSRLLDIIK VAHVVDTNFS YDGPSPVLKG IQVVVLSPSD ELQYGVDESY
NLTIPEKGNP AFAYLTAKTV YGALHGFQTF SQACHFNLTT RSIEVHQVPW TIVDRPRFSY
RGLLIDTSRH YLPLPVILKV IDSMAYAKLN VLHWHIVDTQ SFPLEIPSFP KLWDGAYSSS
ERYTVADASE IVRYAGRRGI NVLAELDVPG HAKSWGIGYP SLWPSKNCQE PLDVSSDFTF
KLIDGILSDF SKIFKYKFVH LGGDEVDTSC WTLTPRISKW LKQHRLNGTS AYEYFVLRAQ
KIALSHGYEI INWEETFNNF GNKLSPKTIV HNWLGGGVAQ QVTAAGLRCI VSNQDKWYLD
HIDTTWQDFY SNEPLTNITK PEQQRLVIGG EVCMWGEHID GSNIETTIWP RAAAAAERLW
TAYDNIAKNP EQAVRRLAYF RCLLNQRGVA SGPLTGGGRA APDEPGSCYE Q
//
