ID M1BKV7_SOLTU Unreviewed; 1169 AA.
AC M1BKV7;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
GN Name=102604473 {ECO:0000313|EnsemblPlants:PGSC0003DMT400047499};
OS Solanum tuberosum (Potato).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX NCBI_TaxID=4113 {ECO:0000313|EnsemblPlants:PGSC0003DMT400047499, ECO:0000313|Proteomes:UP000011115};
RN [1] {ECO:0000313|Proteomes:UP000011115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DM1-3 516 R44 {ECO:0000313|Proteomes:UP000011115};
RX PubMed=21743474; DOI=10.1038/nature10158;
RG The Potato Genome Sequencing Consortium;
RT "Genome sequence and analysis of the tuber crop potato.";
RL Nature 475:189-195(2011).
RN [2] {ECO:0000313|EnsemblPlants:PGSC0003DMT400047499}
RP IDENTIFICATION.
RC STRAIN=DM1-3 516 R44 {ECO:0000313|EnsemblPlants:PGSC0003DMT400047499};
RG EnsemblPlants;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
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DR RefSeq; XP_006361238.1; XM_006361176.2.
DR AlphaFoldDB; M1BKV7; -.
DR PaxDb; 4113-PGSC0003DMT400047499; -.
DR EnsemblPlants; PGSC0003DMT400047499; PGSC0003DMT400047499; PGSC0003DMG400018461.
DR GeneID; 102604473; -.
DR Gramene; PGSC0003DMT400047499; PGSC0003DMT400047499; PGSC0003DMG400018461.
DR KEGG; sot:102604473; -.
DR eggNOG; ENOG502SI7S; Eukaryota.
DR HOGENOM; CLU_001561_0_2_1; -.
DR InParanoid; M1BKV7; -.
DR OMA; IGRFHTH; -.
DR OrthoDB; 995586at2759; -.
DR Proteomes; UP000011115; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0098542; P:defense response to other organism; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR045344; C-JID.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR11017:SF545; ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF20160; C-JID; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000011115}.
FT DOMAIN 13..182
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1169 AA; 133902 MW; EC9F9583ACBD84F8 CRC64;
MASFSNSQYC PPRKYEVFLS FRGEDTRRTF TSHLYEGLKN RGIFTFQDVK RLDHGDSIPE
ELVKAIKESQ ISLVVFSKNY GASRWCLNEL VKIMECKDKN EQTVIPVFYD VDPSHVRNQR
ESFGEAFSKH ESKYKDDIEG MQKVQRWRTA LTVAANLKGY DIRDGIESEK IQQIVDHIST
KLCKSVYSLS SLQDVVGINA HLEKLKSRLQ IEINDVRIVG IWGTGGVGKT TIAKAIFDTL
SYQFKAACFL ADVKENAKKN QMHSLQNILL SELLRKKDDY VNNKYEGKSI IPSRLCSMKV
LIVLDDIDHS DHLEYLAGDL RWFGNGSRVV VTTRNRHLIE KDDAIYEVPT LPDHEAMLLF
NQHAFKKEVP DERFKKFSLE LVNNAKGLPL ALKVWGSLLH KKGLTQWGRT VDQIKNNSIS
EIVEKLKISY DGLEPEEQKI FLDMACFFRG YEKKEVIQIL GSCDFGVEYG LEVLIDKSLV
FISKNDTIEM HDLIQDMGRY VVKMQKDSGE QSRLWAAEDF EEVIVNNTGT KAVEAIWLHY
IQNLCFSKKA MKKMKKLRVL YIGRFHTHDD TIEYLPNNLR WFECIWYPWK SLPENFEPKR
LVHLDLQYSL LRSLWIGTKH FPSLRRINLS FSRSLIRTPV FTGMPNLEYL NLEGCSNLEE
VHHSLGCSKK LIELNLSWCV SLKRFPYVNV ESLESLNLQH CSSLEKFPEI LGRIKPLELD
IQMRKNVIGE LPSSVFQHQA RLTELDLSFL INIIALPSSI GMLKGLVKLH VRYCSKLEIL
PEEIGDLENL EKLDASYSRL ISQPPASIVR LKKLKFLSFE KGNTKVGHKD GVCFVFPHVN
EGLCSLEYLN LNYCNLIDGG LPEDIGCLSS LKELYLWGNN FEHLPRSMAQ LGALKFLNLS
HCKKLKELPS FTGMPNLETL NLIKCMNLEE VHHSLGFLKK LCGLTLTNCI QLKRFPGLCI
DSLKYLCLRD CSSLEKFPDI FGSMKLKSDI HMLDSVMRDL NSMYNSFPRS LSQDIVSLQQ
GMICASDSLS LRVFTVVHCG NKIPSWFHHR GTGKTVSVNL PENWYVRDDL LGFAVCYSGN
LIDTTAHLIP LRDDGMPWMT QKLELSSLPN YDTGCTIHFF LVPLASLWDT STANGNTPND
YGLITFSFSG GMEEYGFRLL YKDELQGKY
//
