ID   M1BZ79_SOLTU            Unreviewed;       456 AA.
AC   M1BZ79;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   27-MAR-2024, entry version 50.
DE   SubName: Full=Disease resistance protein {ECO:0000313|EnsemblPlants:PGSC0003DMT400056267};
OS   Solanum tuberosum (Potato).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX   NCBI_TaxID=4113 {ECO:0000313|EnsemblPlants:PGSC0003DMT400056267, ECO:0000313|Proteomes:UP000011115};
RN   [1] {ECO:0000313|Proteomes:UP000011115}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. DM1-3 516 R44 {ECO:0000313|Proteomes:UP000011115};
RX   PubMed=21743474; DOI=10.1038/nature10158;
RG   The Potato Genome Sequencing Consortium;
RT   "Genome sequence and analysis of the tuber crop potato.";
RL   Nature 475:189-195(2011).
RN   [2] {ECO:0000313|EnsemblPlants:PGSC0003DMT400056267}
RP   IDENTIFICATION.
RC   STRAIN=DM1-3 516 R44 {ECO:0000313|EnsemblPlants:PGSC0003DMT400056267};
RG   EnsemblPlants;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- FUNCTION: Confers resistance to late blight (Phytophthora infestans)
CC       races carrying the avirulence gene Avr1. Resistance proteins guard the
CC       plant against pathogens that contain an appropriate avirulence protein
CC       via an indirect interaction with this avirulence protein. That triggers
CC       a defense system including the hypersensitive response, which restricts
CC       the pathogen growth. {ECO:0000256|ARBA:ARBA00002074}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC       Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC   -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC       {ECO:0000256|ARBA:ARBA00008894}.
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DR   AlphaFoldDB; M1BZ79; -.
DR   PaxDb; 4113-PGSC0003DMT400056267; -.
DR   EnsemblPlants; PGSC0003DMT400056267; PGSC0003DMT400056267; PGSC0003DMG400021862.
DR   Gramene; PGSC0003DMT400056267; PGSC0003DMT400056267; PGSC0003DMG400021862.
DR   eggNOG; KOG4658; Eukaryota.
DR   HOGENOM; CLU_000837_35_8_1; -.
DR   InParanoid; M1BZ79; -.
DR   OMA; LIMVKKM; -.
DR   Proteomes; UP000011115; Unassembled WGS sequence.
DR   ExpressionAtlas; M1BZ79; baseline.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0098542; P:defense response to other organism; IEA:UniProt.
DR   Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR042197; Apaf_helical.
DR   InterPro; IPR044974; Disease_R_plants.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR   PANTHER; PTHR23155:SF1235; DISEASE RESISTANCE RPP13-LIKE PROTEIN 1; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52047; RNI-like; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Hypersensitive response {ECO:0000256|ARBA:ARBA00022667};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011115}.
FT   DOMAIN          1..136
FT                   /note="NB-ARC"
FT                   /evidence="ECO:0000259|Pfam:PF00931"
SQ   SEQUENCE   456 AA;  52830 MW;  AD769B3BDD250F23 CRC64;
     MDDVWDNNAW DDMKRSFPDD KNGSRVILTT RLANVGIYAS SGSLPYYMRC LSVEQSLELF
     NSKVFGRETC PPELEKAIKQ VVEKCQGLPL AIVVVAGFCS KISKTKNCWE DVAHKIGLVV
     SRDTKECLDL LALSYNHLPH HLKSCFLYMG AFPKNIEISV SRLIKQWIAA MFVNCTPEKD
     FEEVSEGYLR DLIDRSLIMV KKMTSSGKVK TCEVHDLLYD IIVRESQKER FIYFTKSNVI
     VSPSVASFEY CIIFNYWKDL WTHLDLDYDI VIPSLPWANS FLCFGRDGTT GFCHQIDSFI
     TFTNFTILAV LDLCFQPFDH LPSEIWKLYS LRYLALASFD VLPPSVRYLR FLQTLICYSH
     QTSICLPVDI REIEQLRHLY FRKCCYFSDN PKDYVYRFSQ LDRALTKMQT LSYISFGSVT
     KSIFEGMPNL KKLGIRERRE ECLTAEQMSG NSRSWF
//