ID   M1CW37_SOLTU            Unreviewed;       983 AA.
AC   M1CW37;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   27-MAR-2024, entry version 42.
DE   SubName: Full=Karyopherin-beta 3 variant {ECO:0000313|EnsemblPlants:PGSC0003DMT400076039};
OS   Solanum tuberosum (Potato).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX   NCBI_TaxID=4113 {ECO:0000313|EnsemblPlants:PGSC0003DMT400076039, ECO:0000313|Proteomes:UP000011115};
RN   [1] {ECO:0000313|Proteomes:UP000011115}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. DM1-3 516 R44 {ECO:0000313|Proteomes:UP000011115};
RX   PubMed=21743474; DOI=10.1038/nature10158;
RG   The Potato Genome Sequencing Consortium;
RT   "Genome sequence and analysis of the tuber crop potato.";
RL   Nature 475:189-195(2011).
RN   [2] {ECO:0000313|EnsemblPlants:PGSC0003DMT400076039}
RP   IDENTIFICATION.
RC   STRAIN=DM1-3 516 R44 {ECO:0000313|EnsemblPlants:PGSC0003DMT400076039};
RG   EnsemblPlants;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   AlphaFoldDB; M1CW37; -.
DR   STRING; 4113.M1CW37; -.
DR   PaxDb; 4113-PGSC0003DMT400076039; -.
DR   EnsemblPlants; PGSC0003DMT400076039; PGSC0003DMT400076039; PGSC0003DMG400029568.
DR   Gramene; PGSC0003DMT400076039; PGSC0003DMT400076039; PGSC0003DMG400029568.
DR   eggNOG; KOG2171; Eukaryota.
DR   HOGENOM; CLU_003794_0_1_1; -.
DR   InParanoid; M1CW37; -.
DR   OMA; YEYILLW; -.
DR   Proteomes; UP000011115; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0061608; F:nuclear import signal receptor activity; IBA:GO_Central.
DR   GO; GO:0008139; F:nuclear localization sequence binding; IBA:GO_Central.
DR   GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR040122; Importin_beta.
DR   InterPro; IPR041653; Importin_rep_4.
DR   InterPro; IPR041389; Importin_rep_6.
DR   InterPro; IPR034085; TOG.
DR   PANTHER; PTHR10527:SF102; BETA-3, PUTATIVE-RELATED; 1.
DR   PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR   Pfam; PF13646; HEAT_2; 1.
DR   Pfam; PF18808; Importin_rep_4; 1.
DR   Pfam; PF18829; Importin_rep_6; 1.
DR   SMART; SM01349; TOG; 1.
DR   SUPFAM; SSF48371; ARM repeat; 2.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011115};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        801..823
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        912..934
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          313..549
FT                   /note="TOG"
FT                   /evidence="ECO:0000259|SMART:SM01349"
SQ   SEQUENCE   983 AA;  109564 MW;  3B0AFF332D4E4D6C CRC64;
     MSTTPKSAKK LPFIDLHSDD DKLRKAAKTL LNYSKKYFPN SLVEELFQAI ECSPPGSHYE
     TLKACSSCVS SLAGLLFPKN EWVLLFHLMF EYLGTNSSNG KLCVMLLWNE LIPKCPEVFV
     PYVDFLIEGF TDLMPTILED HRCRVAAARA SVKLILYYST PASYCKFYGL LEHVIVTLFV
     AIGEEDLVCS LLEDLIVLVG VETAVFKVNI GVVVKYMVRI AENSKLGEKL RQLSIEFIVT
     LAEDREIGCG MMQMVPKEEV TKLLSVLIVM LVHIKDDPCW GNANSDDENE GQLSMCSYAM
     ESLDRLAIAL GGSVIVPCCA VGLFDLFHDQ NWRIRHAAVT AIGLISEGCS KALLLEMEKL
     VQTIVKLIHD EHPRVCWAKI RTIGQLSTYL SPCFQEQYHQ QLLRALIEVL DDIDNPRLQT
     RAASAIQLFS QNCSADVLKP YLHNTVRKLV GFLQRGTAMM KEASLATLAS LAISSQEDSA
     YLYDSLMPYL KVILETVTND TSRTLLAKSM ECITMAAMAV GNLAINDYVE KVTAVLISLH
     ETQTVIEDPM RRLLLLECGR LCKFLGADFL PYLSLVMPVA LKSALLKNYL SVSDNSDTDD
     SDYESMIKAT AGNKKIGIRA ALLEEKALAC HMLCFFSTEL KEGLHLWVNE VVSALVQNLT
     FKFSEEIRMA AVSAMPLLLN SASCAMKKGL LVTGHGKSPV QKLSDTIISS LLDALKKVPG
     SCLSKHQAEK FVDGISKVLS RCSYRKTERE KRAKEHTDSR EQELLKEEAE QHLTICRNIG
     ICLGTMVKKL KASFLPHFDK FLPYVSLMWI VATAIGICAE FGADFLKPHI KGILGHLKTA
     LENPNAKHPD NIMAYEAAVS TCGKLNQFVS EGISYEYILL WLNHLPITCD LDEAKISHEL
     LCSMMETSEQ KVIGLGGSYI PIIIAIFAEV LWAGNNLASE ETRTRIINLL KKFQRELEPL
     VLSKIFETLP LPHQNMLRIV LST
//