ID M1D3J6_SOLTU Unreviewed; 528 AA.
AC M1D3J6;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 49.
DE RecName: Full=FAD-binding PCMH-type domain-containing protein {ECO:0000259|PROSITE:PS51387};
GN Name=102584767 {ECO:0000313|EnsemblPlants:PGSC0003DMT400080468};
OS Solanum tuberosum (Potato).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX NCBI_TaxID=4113 {ECO:0000313|EnsemblPlants:PGSC0003DMT400080468, ECO:0000313|Proteomes:UP000011115};
RN [1] {ECO:0000313|Proteomes:UP000011115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DM1-3 516 R44 {ECO:0000313|Proteomes:UP000011115};
RX PubMed=21743474; DOI=10.1038/nature10158;
RG The Potato Genome Sequencing Consortium;
RT "Genome sequence and analysis of the tuber crop potato.";
RL Nature 475:189-195(2011).
RN [2] {ECO:0000313|EnsemblPlants:PGSC0003DMT400080468}
RP IDENTIFICATION.
RC STRAIN=DM1-3 516 R44 {ECO:0000313|EnsemblPlants:PGSC0003DMT400080468};
RG EnsemblPlants;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: Alkaloid biosynthesis; nicotine biosynthesis.
CC {ECO:0000256|ARBA:ARBA00034114}.
CC -!- SIMILARITY: Belongs to the oxygen-dependent FAD-linked oxidoreductase
CC family. {ECO:0000256|ARBA:ARBA00005466}.
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DR RefSeq; XP_015168428.1; XM_015312942.1.
DR AlphaFoldDB; M1D3J6; -.
DR STRING; 4113.M1D3J6; -.
DR PaxDb; 4113-PGSC0003DMT400080468; -.
DR EnsemblPlants; PGSC0003DMT400080468; PGSC0003DMT400080468; PGSC0003DMG400031327.
DR GeneID; 102584767; -.
DR Gramene; PGSC0003DMT400080468; PGSC0003DMT400080468; PGSC0003DMG400031327.
DR Gramene; RHC06H1G2040.2.1; RHC06H1G2040.2.1.cds.1; RHC06H1G2040.2.
DR KEGG; sot:102584767; -.
DR eggNOG; ENOG502QVGN; Eukaryota.
DR HOGENOM; CLU_018354_6_0_1; -.
DR InParanoid; M1D3J6; -.
DR OMA; IAPKIHE; -.
DR OrthoDB; 1094055at2759; -.
DR UniPathway; UPA00107; -.
DR Proteomes; UP000011115; Unassembled WGS sequence.
DR GO; GO:0005773; C:vacuole; IEA:UniProtKB-KW.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0009820; P:alkaloid metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0042179; P:nicotine biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.30.465.10; -; 1.
DR Gene3D; 3.40.462.20; -; 1.
DR Gene3D; 3.30.43.10; Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2; 1.
DR InterPro; IPR012951; BBE.
DR InterPro; IPR016166; FAD-bd_PCMH.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016167; FAD-bd_PCMH_sub1.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR006094; Oxid_FAD_bind_N.
DR PANTHER; PTHR32448:SF113; BERBERINE BRIDGE ENZYME-LIKE 18; 1.
DR PANTHER; PTHR32448; OS08G0158400 PROTEIN; 1.
DR Pfam; PF08031; BBE; 1.
DR Pfam; PF01565; FAD_binding_4; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR PROSITE; PS51387; FAD_PCMH; 1.
PE 3: Inferred from homology;
KW Alkaloid metabolism {ECO:0000256|ARBA:ARBA00022589};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000011115};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Vacuole {ECO:0000256|ARBA:ARBA00022554}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..528
FT /note="FAD-binding PCMH-type domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004013237"
FT DOMAIN 66..240
FT /note="FAD-binding PCMH-type"
FT /evidence="ECO:0000259|PROSITE:PS51387"
SQ SEQUENCE 528 AA; 60113 MW; 32F02B61608693C8 CRC64;
MKISLFSFLL LLLVLSSSSW STLADNHEAF IQCLSQSNKT YYTPNNSSFS SILQFSIQNL
MFNTTETPKP LVIVTPVSES EVQRVILCAK KTGMHVRVRS AGHDYEGLSY VSEVPFVIVD
LINLRTINVD VNDKSAWVEA GSTIGELYYR IAEKSKTLGF PAGVCPTVGV GGHFSGGGYG
TMMRKYGLSA DNIVDARLVD ANGRILDRVS MGEDLFWAIR GGGGNTFGLV LSWKIKLLDV
PEKVTVFTLD KTLEQNLTKL IHKWQNVAPR FHEDLFIRII IRRVDSSDQG GNNKQTIVAS
FNSLFFGGID RLLPIMQENF PELGLRREDC IEMSWIESIM YFAGFPIEGS FDVLLSRVQP
TTRYFKAKSD YVYQPIPEGG LEGIWRFFFE DEAQSSYMIL TPYGGRMDEI LPSDIPFPHR
AGNLYKIQHL VYWDKEGEEV AERHISWIRR LYSYMAPFVS MFPRAAYVNY RDLDIGMNNK
KGYTSYMQAK VWGMKYFKNN FDRLVHVKTK VDPSNFFWNE QSIPSLTS
//