ID M1D6P6_SOLTU Unreviewed; 420 AA.
AC M1D6P6;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=hydroxymethylglutaryl-CoA lyase {ECO:0000256|ARBA:ARBA00012910};
DE EC=4.1.3.4 {ECO:0000256|ARBA:ARBA00012910};
GN Name=102600078 {ECO:0000313|EnsemblPlants:PGSC0003DMT400083201};
OS Solanum tuberosum (Potato).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX NCBI_TaxID=4113 {ECO:0000313|EnsemblPlants:PGSC0003DMT400083201, ECO:0000313|Proteomes:UP000011115};
RN [1] {ECO:0000313|Proteomes:UP000011115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DM1-3 516 R44 {ECO:0000313|Proteomes:UP000011115};
RX PubMed=21743474; DOI=10.1038/nature10158;
RG The Potato Genome Sequencing Consortium;
RT "Genome sequence and analysis of the tuber crop potato.";
RL Nature 475:189-195(2011).
RN [2] {ECO:0000313|EnsemblPlants:PGSC0003DMT400083201}
RP IDENTIFICATION.
RC STRAIN=DM1-3 516 R44 {ECO:0000313|EnsemblPlants:PGSC0003DMT400083201};
RG EnsemblPlants;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(3S)-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA;
CC Xref=Rhea:RHEA:24404, ChEBI:CHEBI:13705, ChEBI:CHEBI:43074,
CC ChEBI:CHEBI:57288; EC=4.1.3.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001651};
CC -!- PATHWAY: Metabolic intermediate metabolism; (S)-3-hydroxy-3-
CC methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-
CC methylglutaryl-CoA: step 1/1. {ECO:0000256|ARBA:ARBA00005143}.
CC -!- SIMILARITY: Belongs to the HMG-CoA lyase family.
CC {ECO:0000256|ARBA:ARBA00009405}.
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DR RefSeq; XP_006339410.1; XM_006339348.2.
DR AlphaFoldDB; M1D6P6; -.
DR STRING; 4113.M1D6P6; -.
DR PaxDb; 4113-PGSC0003DMT400083201; -.
DR EnsemblPlants; PGSC0003DMT400083201; PGSC0003DMT400083201; PGSC0003DMG400033114.
DR GeneID; 102600078; -.
DR Gramene; PGSC0003DMT400083201; PGSC0003DMT400083201; PGSC0003DMG400033114.
DR KEGG; sot:102600078; -.
DR eggNOG; KOG2368; Eukaryota.
DR HOGENOM; CLU_022138_1_2_1; -.
DR InParanoid; M1D6P6; -.
DR OMA; FQMRNTH; -.
DR OrthoDB; 1210873at2759; -.
DR UniPathway; UPA00896; UER00863.
DR Proteomes; UP000011115; Unassembled WGS sequence.
DR ExpressionAtlas; M1D6P6; baseline.
DR GO; GO:0004419; F:hydroxymethylglutaryl-CoA lyase activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0046951; P:ketone body biosynthetic process; IBA:GO_Central.
DR GO; GO:0006552; P:leucine catabolic process; IBA:GO_Central.
DR CDD; cd07938; DRE_TIM_HMGL; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR043594; HMGL.
DR InterPro; IPR000891; PYR_CT.
DR PANTHER; PTHR42738; HYDROXYMETHYLGLUTARYL-COA LYASE; 1.
DR PANTHER; PTHR42738:SF15; HYDROXYMETHYLGLUTARYL-COA LYASE; 1.
DR Pfam; PF00682; HMGL-like; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
DR PROSITE; PS50991; PYR_CT; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000011115}.
FT DOMAIN 121..388
FT /note="Pyruvate carboxyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS50991"
SQ SEQUENCE 420 AA; 44972 MW; 27C09C93D341E349 CRC64;
MLASKVTKKT LRWRFRTRAL AFEEQFDLLA SGFSRSFSVA RSFGADNTSS LINLSKDTEG
GAFQLRRQMR RDSSCNPLFN QDHRVVRTSI GSFSLSNRYY RSHGHLEDIK DKFLGSVPEV
VKIVEVGPRD GLQNEKTIIP TEVKVELIKL LVSSGLPVVE ATSFVSPKWV PQLADGKDVI
EAVRNLTGVR LPVLTPNLKG FEAAVAAGAK EVAIFAAASE SFSRSNINCS IEDSLSRYRD
VALAAKSHSI PVRGYVSCVV GCPIEGAVSP SKVAQVAKEL VDMGCFEISL GDTIGVGTPG
TVIPMLDAVT QVVPVERLAV HFHDTYGQAL SNILVSLQMG ISIVDSSVSG LGGCPYAKGA
SGNVATEDVI YMLNGLGVKT NVDLRKLLLA GDFICKHLGR PSGSKAAIAL SRTTATASKL
//
