ID M1E7M0_9FIRM Unreviewed; 245 AA.
AC M1E7M0;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE SubName: Full=Prepilin peptidase {ECO:0000313|EMBL:AEE14703.1};
DE EC=3.4.23.43 {ECO:0000313|EMBL:AEE14703.1};
GN ORFNames=Thena_1077 {ECO:0000313|EMBL:AEE14703.1};
OS Thermodesulfobium narugense DSM 14796.
OC Bacteria; Bacillota; Clostridia; Thermoanaerobacterales;
OC Thermodesulfobiaceae; Thermodesulfobium.
OX NCBI_TaxID=747365 {ECO:0000313|EMBL:AEE14703.1, ECO:0000313|Proteomes:UP000011765};
RN [1] {ECO:0000313|EMBL:AEE14703.1, ECO:0000313|Proteomes:UP000011765}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14796 {ECO:0000313|EMBL:AEE14703.1,
RC ECO:0000313|Proteomes:UP000011765};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Han J., Lapidus A., Bruce D., Goodwin L., Pitluck S., Peters L.,
RA Kyrpides N., Mavromatis K., Pagani I., Ivanova N., Ovchinnikova G.,
RA Zhang X., Saunders L., Detter J.C., Tapia R., Han C., Land M., Hauser L.,
RA Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Spring S.,
RA Schroeder M., Brambilla E., Klenk H.-P., Eisen J.A.;
RT "The complete genome of Thermodesulfobium narugense DSM 14796.";
RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the peptidase A24 family.
CC {ECO:0000256|ARBA:ARBA00005801}.
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DR EMBL; CP002690; AEE14703.1; -; Genomic_DNA.
DR RefSeq; WP_013756425.1; NC_015499.1.
DR AlphaFoldDB; M1E7M0; -.
DR STRING; 747365.Thena_1077; -.
DR KEGG; tnr:Thena_1077; -.
DR eggNOG; COG1989; Bacteria.
DR HOGENOM; CLU_057101_0_1_9; -.
DR OrthoDB; 9789291at2; -.
DR Proteomes; UP000011765; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-EC.
DR Gene3D; 1.20.120.1220; -; 1.
DR InterPro; IPR000045; Prepilin_IV_endopep_pep.
DR InterPro; IPR010627; Prepilin_pept_A24_N.
DR PANTHER; PTHR30487:SF0; PREPILIN LEADER PEPTIDASE/N-METHYLTRANSFERASE-RELATED; 1.
DR PANTHER; PTHR30487; TYPE 4 PREPILIN-LIKE PROTEINS LEADER PEPTIDE-PROCESSING ENZYME; 1.
DR Pfam; PF06750; A24_N_bact; 1.
DR Pfam; PF01478; Peptidase_A24; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Hydrolase {ECO:0000313|EMBL:AEE14703.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011765};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 5..24
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 71..91
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 141..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 183..205
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 217..238
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 8..90
FT /note="Prepilin peptidase A24 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF06750"
FT DOMAIN 104..203
FT /note="Prepilin type IV endopeptidase peptidase"
FT /evidence="ECO:0000259|Pfam:PF01478"
SQ SEQUENCE 245 AA; 27232 MW; 388010CAA9A9BE2A CRC64;
MDFVVVIICG AVFGSFLNML IYRLPREQSI LSPPSRCPKC GSFLKWYMNI PILSYIFLGG
KCFYCKETIP IRYLIVEILE VMIFLVCYLD WGFSLEFLLH AWFFTASLGI FFTDLETLLI
PDSFSLLSLI PAIGIAALRG NLVESLAVAA GVFLLFYGVS IITNGGMGGG DTKYSASMSC
FLGVFHSLFG LFTAFLLGSV IGIIFRILGI IKRGEPIPFG PFLVLGCLFS YGFGDYFIRL
YLSLF
//