ID M1EIA5_MUSPF Unreviewed; 336 AA.
AC M1EIA5;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Rho guanine nucleotide exchange factor 4 {ECO:0000313|EMBL:AER94497.1};
DE Flags: Fragment;
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|EMBL:AER94497.1};
RN [1] {ECO:0000313|EMBL:AER94497.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Lungs {ECO:0000313|EMBL:AER94497.1};
RX PubMed=23236062; DOI=10.1128/JVI.02476-12;
RA Leon A.J., Banner D., Xu L., Ran L., Peng Z., Yi K., Chen C., Xu F.,
RA Huang J., Zhao Z., Lin Z., Huang S.H., Fang Y., Kelvin A.A., Ross T.M.,
RA Farooqui A., Kelvin D.J.;
RT "Sequencing, annotation, and characterization of the influenza ferret
RT infectome.";
RL J. Virol. 87:1957-1966(2013).
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DR EMBL; JP005900; AER94497.1; -; mRNA.
DR AlphaFoldDB; M1EIA5; -.
DR HOGENOM; CLU_008436_2_0_1; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd01224; PH_Collybistin_ASEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR47544; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4; 1.
DR PANTHER; PTHR47544:SF1; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 2: Evidence at transcript level;
FT DOMAIN 1..115
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 146..253
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AER94497.1"
FT NON_TER 336
FT /evidence="ECO:0000313|EMBL:AER94497.1"
SQ SEQUENCE 336 AA; 39282 MW; D99EB58BA43B9DF4 CRC64;
ERPHLSELGA CFLEHQADFQ IYSEYCNNHP NACVELSRLT KLSKYVYFFE ACRLLQKMID
ISLDGFLLTP VQKICKYPLQ LAELLKYTPP QHRDFKDVEA ALHAMRNVAQ LINERKRRLE
NIDKIAQWQS SIEDWEGEDI LVRSSELIYS GELTRVTQPQ AKSQQRMFFL FDHQLIYCKK
DLLRRDVLYY KGRVDMDGQE VVDLEDGKDR DLHVSVKNAF RLLCGTTGES HLLCARKSEQ
KQRWLKAFAK EREQVRLDQE TGFSITELQR KQAMLNASKQ QATGKPKALS RPYYLARQKH
PVLPTSLPQQ QVLVLAEPKR KPSTFWHSIS RLAPFR
//
