ID M1HE54_AEGMA Unreviewed; 391 AA.
AC M1HE54;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Type III polyketide synthase {ECO:0000313|EMBL:AGE44109.1};
OS Aegle marmelos (Bael tree) (Crateva marmelos).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Sapindales; Rutaceae; Aurantioideae; Aegle.
OX NCBI_TaxID=68527 {ECO:0000313|EMBL:AGE44109.1};
RN [1] {ECO:0000313|EMBL:AGE44109.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23329842; DOI=10.1074/jbc.M112.429886;
RA Resmi M.S., Verma P., Gokhale R.S., Soniya E.V.;
RT "Identification and Characterization of a Type III Polyketide Synthase
RT Involved in Quinolone Alkaloid Biosynthesis from Aegle marmelos Correa.";
RL J. Biol. Chem. 288:7271-7281(2013).
RN [2] {ECO:0007829|PDB:6L61, ECO:0007829|PDB:6L73}
RP X-RAY CRYSTALLOGRAPHY (1.40 ANGSTROMS).
RA Mallika V., Abhinav K.V., Soniya E.V.;
RT "Quinolone synthase from Aegle marmelos Correa, Dimer.";
RL Submitted (OCT-2019) to the PDB data bank.
RN [3] {ECO:0007829|PDB:6L5U, ECO:0007829|PDB:6L78}
RP X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS).
RA Mallika V., Abhinav K.V., Soniya E.V.;
RT "Quinolone synthase from Aegle marmelos Correa.";
RL Submitted (OCT-2019) to the PDB data bank.
RN [4] {ECO:0007829|PDB:6L7J}
RP X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) IN COMPLEX WITH COA.
RA Mallika V., Abhinav K.V., Soniya E.V.;
RT "Quinolone synthase from Aegle marmelos Correa, complexed with Coenzyme
RT A.";
RL Submitted (NOV-2019) to the PDB data bank.
RN [5] {ECO:0007829|PDB:7CCT}
RP X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS).
RA Mallika V., Abhinav K.V., Soniya E.V.;
RT "Quinolone synthase from Aegle marmelos Correa complexed with N-
RT Methylanthraniloyl-CoA.";
RL Submitted (JUN-2020) to the PDB data bank.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC synthases family. {ECO:0000256|ARBA:ARBA00005531,
CC ECO:0000256|RuleBase:RU003633}.
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DR EMBL; JX679859; AGE44109.1; -; mRNA.
DR EMBL; JX679860; AGE44110.1; -; Genomic_DNA.
DR PDB; 6L5U; X-ray; 1.85 A; A=1-391.
DR PDB; 6L61; X-ray; 1.40 A; A/B=1-391.
DR PDB; 6L73; X-ray; 2.00 A; A/B/C/D=1-391.
DR PDB; 6L78; X-ray; 1.55 A; A/B/C/D=1-391.
DR PDB; 6L7J; X-ray; 1.80 A; A=1-391.
DR PDB; 7CCT; X-ray; 2.35 A; A=1-391.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR CDD; cd00831; CHS_like; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR InterPro; IPR018088; Chalcone/stilbene_synthase_AS.
DR InterPro; IPR011141; Polyketide_synthase_type-III.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11877:SF56; CHALCONE SYNTHASE; 1.
DR PANTHER; PTHR11877; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; 1.
DR Pfam; PF02797; Chal_sti_synt_C; 1.
DR Pfam; PF00195; Chal_sti_synt_N; 1.
DR PIRSF; PIRSF000451; PKS_III; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00441; CHALCONE_SYNTH; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:6L5U, ECO:0007829|PDB:6L61};
KW Acyltransferase {ECO:0000256|RuleBase:RU003633};
KW Transferase {ECO:0000256|RuleBase:RU003633}.
FT DOMAIN 5..228
FT /note="Chalcone/stilbene synthase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00195"
FT DOMAIN 239..388
FT /note="Chalcone/stilbene synthase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02797"
FT ACT_SITE 164
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000451-1"
FT BINDING 55
FT /ligand="CoA"
FT /ligand_id="ChEBI:CHEBI:57287"
FT /evidence="ECO:0007829|PDB:6L7J"
FT BINDING 267
FT /ligand="CoA"
FT /ligand_id="ChEBI:CHEBI:57287"
FT /evidence="ECO:0007829|PDB:6L7J"
FT BINDING 305
FT /ligand="CoA"
FT /ligand_id="ChEBI:CHEBI:57287"
FT /evidence="ECO:0007829|PDB:6L7J"
FT BINDING 308
FT /ligand="CoA"
FT /ligand_id="ChEBI:CHEBI:57287"
FT /evidence="ECO:0007829|PDB:6L7J"
SQ SEQUENCE 391 AA; 42833 MW; A91BEE4694B4A148 CRC64;
MVTMEEIRKA QRAEGLATIL AISTATPPNC VIQADYPDYY FKITNSEHMT ELKEKFRRLC
EKSMIRKRHM CLTEEILKAN PNMCLHMGTS LNARQDISLV EVPKLGKEAA TKAIKEWGQP
KSKITHLIFC TSAGVDMPGA DYQLTRLLGL SPEVKRMMIY QQGCYAGATV LRLAKDLTEN
NKGSRVLIVC SENTVPTFRG PSDTHIDSLV GQALFADGAA ALIVGADPDA SIERPLYHIV
SASQTLLPDS DGAIEGHIRE AGLTVHLKKD VPAFFSANIE KSLVDAFTPI GISDWNSIFW
IAHPGGPAIL DQVEEKLGLR KDKLKASRHV MSEFGNMSSA CVLFILDEMR KTCLEEGKAT
TGEGLDWGVL FGFGPGLTVE TVVLRSVPIE A
//
