ID M1IXI8_9CREN Unreviewed; 219 AA.
AC M1IXI8;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=3-methyl-2-oxobutanoate hydroxymethyltransferase {ECO:0000256|ARBA:ARBA00012618};
DE EC=2.1.2.11 {ECO:0000256|ARBA:ARBA00012618};
GN Name=panB {ECO:0000313|EMBL:AGE73162.1};
GN ORFNames=SacRon12I_04590 {ECO:0000313|EMBL:AGE73162.1};
OS Sulfolobus acidocaldarius Ron12/I.
OC Archaea; Thermoproteota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Sulfolobus.
OX NCBI_TaxID=1028567 {ECO:0000313|Proteomes:UP000011280};
RN [1] {ECO:0000313|EMBL:AGE73162.1, ECO:0000313|Proteomes:UP000011280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ron12/I {ECO:0000313|EMBL:AGE73162.1,
RC ECO:0000313|Proteomes:UP000011280};
RX PubMed=22418622; DOI=10.1038/ismej.2012.20;
RA Mao D., Grogan D.;
RT "Genomic evidence of rapid, global-scale gene flow in a Sulfolobus
RT species.";
RL ISME J. 6:1613-1616(2012).
CC -!- SIMILARITY: Belongs to the PanB family.
CC {ECO:0000256|ARBA:ARBA00008676}.
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DR EMBL; CP002818; AGE73162.1; -; Genomic_DNA.
DR AlphaFoldDB; M1IXI8; -.
DR KEGG; sacr:SacRon12I_04590; -.
DR PATRIC; fig|1028567.7.peg.902; -.
DR HOGENOM; CLU_036645_1_0_2; -.
DR Proteomes; UP000011280; Chromosome.
DR GO; GO:0003864; F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0015937; P:coenzyme A biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0015940; P:pantothenate biosynthetic process; IEA:InterPro.
DR CDD; cd06557; KPHMT-like; 1.
DR Gene3D; 3.20.20.60; Phosphoenolpyruvate-binding domains; 1.
DR InterPro; IPR003700; Pantoate_hydroxy_MeTrfase.
DR InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR InterPro; IPR040442; Pyrv_Kinase-like_dom_sf.
DR NCBIfam; TIGR00222; panB; 1.
DR PANTHER; PTHR20881; 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE; 1.
DR PANTHER; PTHR20881:SF0; 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE; 1.
DR Pfam; PF02548; Pantoate_transf; 1.
DR SUPFAM; SSF51621; Phosphoenolpyruvate/pyruvate domain; 1.
PE 3: Inferred from homology;
KW Coenzyme A biosynthesis {ECO:0000256|ARBA:ARBA00022993};
KW Methyltransferase {ECO:0000313|EMBL:AGE73162.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AGE73162.1}.
SQ SEQUENCE 219 AA; 24423 MW; 04CC719ECB9A8E79 CRC64;
MVVLGYENTL KVSMKEMLVH LDSVVRAKPR QLVVADMPFL SYEVSANTAV KNAGLFVRHG
ADSVKLEGGE EMADVVRKIV RAGIPVMGHI GLTPQRFLRI GGFRVLGKSK HEEEQLLRDA
EVLEEAGIFS LVIENTYADV AKKITEKLKV PTICIGAGPY CDGQILVIHD VLGLSEFTPY
FAKAYVNLKE EIQKAVNKYV EEVRESKFPQ GENYKERES
//
