ID   M1IY37_9CREN            Unreviewed;       639 AA.
AC   M1IY37;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 51.
DE   SubName: Full=3-hydroxybutyryl-CoA {ECO:0000313|EMBL:AGE72109.1};
GN   ORFNames=SacN8_10815 {ECO:0000313|EMBL:AGE72109.1};
OS   Sulfolobus acidocaldarius N8.
OC   Archaea; Thermoproteota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Sulfolobus.
OX   NCBI_TaxID=1028566 {ECO:0000313|Proteomes:UP000011281};
RN   [1] {ECO:0000313|EMBL:AGE72109.1, ECO:0000313|Proteomes:UP000011281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=N8 {ECO:0000313|EMBL:AGE72109.1,
RC   ECO:0000313|Proteomes:UP000011281};
RX   PubMed=22418622; DOI=10.1038/ismej.2012.20;
RA   Mao D., Grogan D.;
RT   "Genomic evidence of rapid, global-scale gene flow in a Sulfolobus
RT   species.";
RL   ISME J. 6:1613-1616(2012).
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|ARBA:ARBA00005005}.
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DR   EMBL; CP002817; AGE72109.1; -; Genomic_DNA.
DR   RefSeq; WP_011279006.1; NC_020246.1.
DR   AlphaFoldDB; M1IY37; -.
DR   GeneID; 78440206; -.
DR   KEGG; sacn:SacN8_10815; -.
DR   PATRIC; fig|1028566.6.peg.2177; -.
DR   HOGENOM; CLU_010448_2_1_2; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000011281; Chromosome.
DR   GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   CDD; cd06558; crotonase-like; 1.
DR   Gene3D; 1.10.12.10; Lyase 2-enoyl-coa Hydratase, Chain A, domain 2; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR014748; Enoyl-CoA_hydra_C.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR23309; 3-HYDROXYACYL-COA DEHYROGENASE; 1.
DR   PANTHER; PTHR23309:SF9; PEROXISOMAL BIFUNCTIONAL ENZYME; 1.
DR   Pfam; PF00725; 3HCDH; 2.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF52096; ClpP/crotonase; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   NAD {ECO:0000256|ARBA:ARBA00023027}; NADP {ECO:0000256|ARBA:ARBA00022857};
KW   Peroxisome {ECO:0000256|ARBA:ARBA00023140}.
FT   DOMAIN          2..181
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          184..277
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
FT   DOMAIN          294..367
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
SQ   SEQUENCE   639 AA;  71237 MW;  6E281B6AE3F093C6 CRC64;
     MKVVVIGSGE MGHGIAEVMA IYKNEVTLVD IKDEILDKAI SKIRESLDRL KKRGSIEEEP
     EDILKRITKS INLEEAVKDA DLVIEAVPEI VDLKQNIFKR LDQFTKPDAI LATNTSNIRI
     SEISKFVNKK DRVVGMHFFN PPVLMQLVEI IKGPDTSPEV VQKLYEITKQ IGKTPVIVNK
     DTPGFIVNRI NAAESLFICL VLQKGINYEE VDAYFRSLGL PMGPYELMDY VGLDIVAHSL
     EYFAKEISPE YGKCTKIKEM VNNGLLGRKS GRGFYDWTKG RPQINAKQNP IIDVNDLLAI
     DINEASKLLE DNVATPNDIE TAVKLGMNRP FGPITVAKSA DLNDVKSRLE RISSEYGITI
     FQPTDSIKTG KLKELLEGEK KEEKKEFETL NVSKEGKVAI VKLNRPKLNL INYTLLDELD
     RLLTELWNDR SINVILITGE GQNFSGGAEL SAPITDQVQF LELVRKGERT FKRLTEIPKI
     VIAFVKGYAL GGGFELSSYC DLRIATENAV FGFPETGLGL VPAWGGTQRL PKLIGISRAM
     YLILTAQRIS AKEALEYGLV NKIVKDENEA LEFAKDLSER IAPISAMLAK RLINRGSEVP
     IDVGLEMESI AGGLLFTTED LKEGIVAFFS KRKPEFKGK
//