ID M1J0N7_9CREN Unreviewed; 416 AA.
AC M1J0N7;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=protein-synthesizing GTPase {ECO:0000256|ARBA:ARBA00011986};
DE EC=3.6.5.3 {ECO:0000256|ARBA:ARBA00011986};
GN ORFNames=SacRon12I_04025 {ECO:0000313|EMBL:AGE73049.1};
OS Sulfolobus acidocaldarius Ron12/I.
OC Archaea; Thermoproteota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Sulfolobus.
OX NCBI_TaxID=1028567 {ECO:0000313|Proteomes:UP000011280};
RN [1] {ECO:0000313|EMBL:AGE73049.1, ECO:0000313|Proteomes:UP000011280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ron12/I {ECO:0000313|EMBL:AGE73049.1,
RC ECO:0000313|Proteomes:UP000011280};
RX PubMed=22418622; DOI=10.1038/ismej.2012.20;
RA Mao D., Grogan D.;
RT "Genomic evidence of rapid, global-scale gene flow in a Sulfolobus
RT species.";
RL ISME J. 6:1613-1616(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.3;
CC Evidence={ECO:0000256|ARBA:ARBA00001874};
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. EIF2G subfamily.
CC {ECO:0000256|ARBA:ARBA00005388}.
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DR EMBL; CP002818; AGE73049.1; -; Genomic_DNA.
DR RefSeq; WP_011277701.1; NC_020247.1.
DR AlphaFoldDB; M1J0N7; -.
DR GeneID; 78441179; -.
DR KEGG; sacr:SacRon12I_04025; -.
DR PATRIC; fig|1028567.7.peg.790; -.
DR HOGENOM; CLU_027154_0_1_2; -.
DR Proteomes; UP000011280; Chromosome.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0000049; F:tRNA binding; IEA:InterPro.
DR CDD; cd01888; eIF2_gamma; 1.
DR CDD; cd03688; eIF2_gamma_II; 1.
DR CDD; cd15490; eIF2_gamma_III; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015256; eIF2g_C.
DR InterPro; IPR044127; eIF2g_dom_2.
DR InterPro; IPR044128; eIF2g_GTP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR022424; TIF2_gsu.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR NCBIfam; TIGR03680; eif2g_arch; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR42854; EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER; 1.
DR PANTHER; PTHR42854:SF3; EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED; 1.
DR Pfam; PF09173; eIF2_C; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000313|EMBL:AGE73049.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917}.
FT DOMAIN 7..206
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 416 AA; 45512 MW; DF0016FA90DEA414 CRC64;
MAWPRVQPEA NIGVVGHVDH GKTTLVQALT GIWTSKHSEE LKRGMTIKLG YAEANIGLCE
SCKLPDGYVT EPSCSQCNSS EEPKFLRKVS FIDAPGHEIL MATMLSGAAL MDGAILVVAA
NEPFPQPQTR EHFVALGIVD VKRLVIVQNK VDVVSREEAI KQYKQIREFL KGTWAENAPI
IPASSLHKIN IDAVIGALQD HIPTPERDLS KDPIMLIIRS FDVNKPGTSY DKLSGGVIGG
SIIQGKFKVG DEIKILPGIR IEKPDGKAEY IPLYTTISSI RFMDLEVEEA KPGGLVAIGT
KLDPSYVKAD NLIGSVAVKA DRDIPVVTEV TIENFQLLER VVGTKELVKV DSIRPKESLM
ISFGSATTIG VTKSVKGGRV EVELKRPIVL WDKNLRIVVS RQIGGRWRLI GWGIIS
//
