ID M1K742_ENCCN Unreviewed; 818 AA.
AC M1K742;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Coatomer subunit beta {ECO:0000256|PIRNR:PIRNR005727};
DE AltName: Full=Beta-coat protein {ECO:0000256|PIRNR:PIRNR005727};
GN ORFNames=ECU08_1100 {ECO:0000313|EMBL:AGE95017.1};
OS Encephalitozoon cuniculi (Microsporidian parasite).
OC Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC Encephalitozoon.
OX NCBI_TaxID=6035 {ECO:0000313|EMBL:AGE95017.1};
RN [1] {ECO:0000313|EMBL:AGE95017.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23376943; DOI=10.1128/EC.00307-12;
RA Selman M., Sak B., Kvac M., Farinelli L., Weiss L.M., Corradi N.;
RT "Extremely Reduced Levels of Heterozygosity in the Vertebrate Pathogen
RT Encephalitozoon cuniculi.";
RL Eukaryot. Cell 12:496-502(2013).
CC -!- FUNCTION: The coatomer is a cytosolic protein complex that binds to
CC dilysine motifs and reversibly associates with Golgi non-clathrin-
CC coated vesicles, which further mediate biosynthetic protein transport
CC from the ER, via the Golgi up to the trans Golgi network. Coatomer
CC complex is required for budding from Golgi membranes, and is essential
CC for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
CC {ECO:0000256|PIRNR:PIRNR005727}.
CC -!- SUBUNIT: Oligomeric complex that consists of at least the alpha, beta,
CC beta', gamma, delta, epsilon and zeta subunits.
CC {ECO:0000256|PIRNR:PIRNR005727}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR005727}. Golgi
CC apparatus membrane {ECO:0000256|ARBA:ARBA00004255,
CC ECO:0000256|PIRNR:PIRNR005727}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004255, ECO:0000256|PIRNR:PIRNR005727};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004255,
CC ECO:0000256|PIRNR:PIRNR005727}. Cytoplasmic vesicle, COPI-coated
CC vesicle membrane {ECO:0000256|PIRNR:PIRNR005727}; Peripheral membrane
CC protein {ECO:0000256|PIRNR:PIRNR005727}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR005727}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR EMBL; KC513605; AGE95017.1; -; Genomic_DNA.
DR AlphaFoldDB; M1K742; -.
DR VEuPathDB; MicrosporidiaDB:AEWD_081090; -.
DR VEuPathDB; MicrosporidiaDB:AEWQ_081130; -.
DR VEuPathDB; MicrosporidiaDB:AEWR_081140; -.
DR VEuPathDB; MicrosporidiaDB:ECU08_1100; -.
DR VEuPathDB; MicrosporidiaDB:M970_081140; -.
DR GO; GO:0030126; C:COPI vesicle coat; IEA:InterPro.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR InterPro; IPR011710; Coatomer_bsu_C.
DR InterPro; IPR016460; COPB1.
DR InterPro; IPR029446; COPB1_appendage_platform_dom.
DR PANTHER; PTHR10635; COATOMER SUBUNIT BETA; 1.
DR PANTHER; PTHR10635:SF0; COATOMER SUBUNIT BETA; 1.
DR Pfam; PF01602; Adaptin_N; 1.
DR Pfam; PF07718; Coatamer_beta_C; 1.
DR Pfam; PF14806; Coatomer_b_Cpla; 1.
DR PIRSF; PIRSF005727; Coatomer_beta_subunit; 2.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR005727};
KW Cytoplasmic vesicle {ECO:0000256|PIRNR:PIRNR005727};
KW ER-Golgi transport {ECO:0000256|ARBA:ARBA00022892,
KW ECO:0000256|PIRNR:PIRNR005727};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034,
KW ECO:0000256|PIRNR:PIRNR005727};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR005727};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR005727}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005727}.
FT DOMAIN 16..188
FT /note="Clathrin/coatomer adaptor adaptin-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01602"
FT DOMAIN 575..674
FT /note="Coatomer beta subunit C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07718"
FT DOMAIN 689..805
FT /note="Coatomer beta subunit appendage platform"
FT /evidence="ECO:0000259|Pfam:PF14806"
SQ SEQUENCE 818 AA; 93657 MW; B8F98FE29170F834 CRC64;
MQASLYLNTS MRMRKDEIMQ KLRSSSEQDK IEGMKQMIAQ MSQGEDFSSL THKITKETLV
VRSNELKRLF YYYLELLPKA RGTQSFEEML LLSNQVRKDL EHPNEYVRGF VMRFVSTLDD
QELVGNFYKL IKDNFNHPNT YVRRNAYFCL GEIFLKMDMY KEVPDLLYHA LLRDLDPNCL
REAFVSLHLT DPELALKYAG EVSLSIPSEL STAIVEKIKD ERLLERFLFS EDSMTAFEAG
MSIHRMSNDE QLLKRSTDTI LRCLEDLPRC REYAIDELLL STYSFSGYAM SFLSLIDPYD
LSFCSKCFDF VFKISETHEF LQISDFLAFR FMDTHDASVQ NQSFRVLLLE KMAYFASTYS
SYNEEMVSEA LKSIASDNPE MSHASLMFLS SCFEIMSRSS ESCEGDAAGH GSYLEVLVNK
INEVKYGKIL RCCFGILRRH ATKEIFLRVV EVLESSFGHA DRPLYLRNTQ TFLGAFMCIE
LSEMCRRLEG PKDRVIAVML RFIEHGKESN TIDMSSQSTI VSCIRSLVSC NSQGEVSSNG
HKRCREGVLD PIMLPGTRSS DERGLNKLNE FLVDSEGGSA EMRNVTQLTG LSDPIYVEAT
TSYTRYEIVV DMLFINQTPS YLQNILLDFV TSQGLSATFI STPFSLSSRS VVTKRFTFRI
IDASNGFISG SITFRYPDEC GEYANTVYTI NLSEVKTSVS EFLEPRKMDP DGFRETWKEL
EWENTYTLKF ITKKTLEEIF GEVSRVLNGE TLDIECDEDY AVGNIACSTL QNVCVLVNVC
LRRSEHVHFE SRIRSRKEGI VKSVSAVVGD VLRSLKNK
//
