ID   M1K7G7_ENCCN            Unreviewed;       933 AA.
AC   M1K7G7;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   SubName: Full=Putative ATP-dependent RNA helicase {ECO:0000313|EMBL:AGE95202.1};
GN   ORFNames=ECU04_0910 {ECO:0000313|EMBL:AGE95202.1};
OS   Encephalitozoon cuniculi (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC   Encephalitozoon.
OX   NCBI_TaxID=6035 {ECO:0000313|EMBL:AGE95202.1};
RN   [1] {ECO:0000313|EMBL:AGE95202.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23376943; DOI=10.1128/EC.00307-12;
RA   Selman M., Sak B., Kvac M., Farinelli L., Weiss L.M., Corradi N.;
RT   "Extremely Reduced Levels of Heterozygosity in the Vertebrate Pathogen
RT   Encephalitozoon cuniculi.";
RL   Eukaryot. Cell 12:496-502(2013).
CC   -!- SIMILARITY: Belongs to the helicase family. SKI2 subfamily.
CC       {ECO:0000256|ARBA:ARBA00010140}.
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DR   EMBL; KC513606; AGE95202.1; -; Genomic_DNA.
DR   AlphaFoldDB; M1K7G7; -.
DR   VEuPathDB; MicrosporidiaDB:AEWD_040850; -.
DR   VEuPathDB; MicrosporidiaDB:AEWQ_040840; -.
DR   VEuPathDB; MicrosporidiaDB:AEWR_040840; -.
DR   VEuPathDB; MicrosporidiaDB:ECU04_0910; -.
DR   VEuPathDB; MicrosporidiaDB:M970_040840; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR   GO; GO:0006401; P:RNA catabolic process; IEA:InterPro.
DR   CDD; cd18795; SF2_C_Ski2; 1.
DR   Gene3D; 1.10.3380.30; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR016438; SKI2-like.
DR   InterPro; IPR012961; Ski2/MTR4_C.
DR   PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR   PANTHER; PTHR12131:SF7; EXOSOME RNA HELICASE MTR4; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF08148; DSHCT; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   PIRSF; PIRSF005198; Antiviral_helicase_SKI2; 2.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM01142; DSHCT; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:AGE95202.1};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT   DOMAIN          79..235
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          313..481
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
SQ   SEQUENCE   933 AA;  106869 MW;  C04D27530D41E781 CRC64;
     MIDDKYFDVF NDKSTLQAIA VPERLERRTT VTDRIDRNGT RHEAVVPVGA AYTPLPKQFC
     KPAAKNYLFE LDDFQKISVC SLERDESVLV SAHTSSGKTV VAEYAIAMSL RSNQRVVYTS
     PIKALSNQKY RELLSEFSDV GLMTGDVTIN PTASCLVMTT EILRNMLYRG GEVVREIHWI
     IFDEIHYMRD KERGVVWEET IILLPKHVRM VFLSATIPNA LEFAEWISHI QSQVVHVVYT
     EKRVTPLVHY FRSNKLYKIK DAKFHKSNFL SAMRSIRKRN VGPREVGEAI GDASLPVVVF
     SFKRKDCERF AMKLDGRYLT DEEARTVQTI FTNAIMSLRK EDREIPIIQN ILPLLMRGIG
     IHHSGLLPII KEVVEILFQE GLLKVLFATE TFSIGLNMPA KSVVFTALKK FDGEAMRLVS
     SGEYIQMSGR AGRRGIDSMG IVISIISEPI TYKEASRLFS ASSDNLVSAF RLTYNMLLNL
     MRVEGLDPLY LISRSFHHFQ SYKKALAEEE TLHSMYRRLE DIEPNETACL YRKREEKKVE
     RGKRLVEAFG KYLKKGRVVD LFIPRNGPSI TIRNAIVSKA REKVQCMVGT EEGVYMCSFP
     LHYIDCVYDI RVKLDVRVFT KSFEKIAVRD ELDEEIEEIE GKILSMDPEW SFDFCVLCGK
     SSVGCLVSCS RELIDSEAVI VQMPENTKRY GESLEAARYP STEMKSNMDG ARAFFVNETL
     RQRYLEKLLE LNSLKEIYHM RECKKMIEVL KKLEYCDDTT VLIKGRMACE ISSGDELVLT
     EMIFNGDFAG IPVEHFVPLL SCIVFEEWDS DNFVLSDENK LYYRLLSDSV EKVCKVLKSC
     GIEIDPAAYL KRFSYELMDV VRMWVCGCTF ISICSKTSIF EGSIIRTFKR LEELLRQLSS
     AARVIGNTEL ENMFALGIVK IKRDIVFANS LYI
//