ID M1MCL9_9CLOT Unreviewed; 349 AA.
AC M1MCL9;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=3-methylornithine synthase PylB {ECO:0000313|EMBL:AGF54158.1};
DE EC=5.4.99.- {ECO:0000313|EMBL:AGF54158.1};
GN Name=pylB {ECO:0000313|EMBL:AGF54158.1};
GN ORFNames=Cspa_c03400 {ECO:0000313|EMBL:AGF54158.1};
OS Clostridium saccharoperbutylacetonicum N1-4(HMT).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=931276 {ECO:0000313|EMBL:AGF54158.1, ECO:0000313|Proteomes:UP000011728};
RN [1] {ECO:0000313|EMBL:AGF54158.1, ECO:0000313|Proteomes:UP000011728}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=N1-4(HMT) {ECO:0000313|Proteomes:UP000011728};
RA Poehlein A., Daniel R.;
RT "Genome sequence of Clostridium saccharoperbutylacetonicum N1-4(HMT).";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135;
CC Evidence={ECO:0000256|ARBA:ARBA00034078};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; CP004121; AGF54158.1; -; Genomic_DNA.
DR RefSeq; WP_015390484.1; NZ_AOIF01000150.1.
DR AlphaFoldDB; M1MCL9; -.
DR STRING; 36745.CLSAP_03350; -.
DR KEGG; csr:Cspa_c03400; -.
DR PATRIC; fig|931276.5.peg.320; -.
DR eggNOG; COG0502; Bacteria.
DR HOGENOM; CLU_033172_0_1_9; -.
DR OrthoDB; 9775764at2; -.
DR Proteomes; UP000011728; Chromosome.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0044271; P:cellular nitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0018130; P:heterocycle biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044272; P:sulfur compound biosynthetic process; IEA:UniProt.
DR GO; GO:0042364; P:water-soluble vitamin biosynthetic process; IEA:UniProt.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR010722; BATS_dom.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR024021; FeFe-hyd_HydE_rSAM.
DR InterPro; IPR034422; HydE/PylB-like.
DR InterPro; IPR007197; rSAM.
DR NCBIfam; TIGR03956; rSAM_HydE; 1.
DR PANTHER; PTHR43726; 3-METHYLORNITHINE SYNTHASE; 1.
DR PANTHER; PTHR43726:SF1; BIOTIN SYNTHASE; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR PIRSF; PIRSF004762; CHP00423; 1.
DR SFLD; SFLDG01082; B12-binding_domain_containing; 1.
DR SFLD; SFLDG01060; BATS_domain_containing; 1.
DR SFLD; SFLDF00348; FeFe_hydrogenase_maturase_(Hyd; 1.
DR SMART; SM00876; BATS; 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Isomerase {ECO:0000313|EMBL:AGF54158.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000011728};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 46..259
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 349 AA; 39104 MW; 7E99B8BA576E5779 CRC64;
MIKLIEKAKT THNLNESEIL QLLQNDDINQ ELFKAADDVR QKYLGDFVHL RGLIEFTNIC
KRNCLYCGLR RDNKNIERYR LTEEEILDFA KKAVTYGYRT LVLQGGEDDF FTIERMTKIV
QEIKKLGVAL TLSLGEKTYD EYKAFKAAGA DRYLIRIETT DKKLYEAMDP EMSFEERLNC
LNNLRDLGYE VGSGILVGLP NQTLESIAKD ILFFKEINAD MIGIGPFIPN EDTPLKDAEG
GNLTLALKVM ALTRLLLPDI NIPATTAMES LAPNGRIVAL QSGANVVMPN VTEGEYRKLY
ALYPGKICTG DTPAHCRGCI TGKVTGIGRI ISDGYGFRGN QNTNAHDKN
//
