ID M1R4V7_MYTGA Unreviewed; 860 AA.
AC M1R4V7;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Toll-like receptor e {ECO:0000313|EMBL:AGG10803.1};
OS Mytilus galloprovincialis (Mediterranean mussel).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Mytilida; Mytiloidea; Mytilidae; Mytilinae;
OC Mytilus.
OX NCBI_TaxID=29158 {ECO:0000313|EMBL:AGG10803.1};
RN [1] {ECO:0000313|EMBL:AGG10803.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23485525; DOI=10.1016/j.dci.2013.02.006;
RA Toubiana M., Gerdol M., Rosani U., Pallavicini A., Venier P., Roch P.;
RT "Toll-like receptors and MyD88 adaptors in Mytilus: Complete cds and gene
RT expression levels.";
RL Dev. Comp. Immunol. 40:158-166(2013).
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; KC344670; AGG10803.1; -; mRNA.
DR AlphaFoldDB; M1R4V7; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365:SF541; MSTPROX-RELATED; 1.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF01582; TIR; 1.
DR PIRSF; PIRSF037595; Toll-like_receptor; 6.
DR PRINTS; PR01537; INTRLKN1R1F.
DR SMART; SM00365; LRR_SD22; 4.
DR SMART; SM00369; LRR_TYP; 7.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 3.
DR PROSITE; PS50104; TIR; 1.
PE 2: Evidence at transcript level;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius}; Receptor {ECO:0000313|EMBL:AGG10803.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..860
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004016907"
FT TRANSMEM 669..688
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 718..859
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 860 AA; 99562 MW; 166316C5B386FBD2 CRC64;
MRNKHILHAI ICLNSLITIY GNTQHHPCSF LPRCRCRLEH HTNFVEVDCS HIQLKRIPSV
PSYVIKLIMK HNLIAVIPNG VFSNNTILTE LDLSDNRIHT LTEMSFNGLQ NLLKLSLQNN
YLSKGNISFG ASTFSHLKNL KYLNLKNNFA KHYQPDLSKL VSLESLQIDF LSNGISFMSE
QYRKLKNLAM LDLSGLSGKC SLPILKSESF KFISQVRHLD ISTCNIQQIY RGALSVLKNL
TYLDVSNNTC IKFEGLENIT SDLQFSNINI LKVSYLHKMS DLTTVLKTSH IKGLHNTSLQ
NVYVDGNRIQ TIEKNALTYL PKSLKFLSVR QNPFKFGYYL EDVLHLSNLE TANISDLYRH
KTNFYPEKCF FESICTCNED SVNEPSCMDQ SRISSRYVKD KIRKGDIPDI FSLIEIPIPT
NLKHINYSSG SLVMDLPKLM FSRNKLETVD ISNNILHSLI GPIFNVTSLK TLNVANNFCS
NISNFFFSTD FKNLERLNFQ NNLLGYVLPD DIDGKIFHNL KSLTDLMLSK NRIPNLPKKI
LKSQRNLQKL DLSDNILTDI TFRVSHMMHL QELDLSGNRI TIISAPITSQ LNSLARKNNF
SVDLNDNLLE CNCISIKFIE WMTTTNVRLK NIKKYKCMLW NRTIVTLHNP KETYNLLKKH
CTSYEQLEIA LVSGILLFIA IIVGAVVYRF RWKLRYLYYI VKVKYSSLHS ETEEEYSYMY
GAFVSYADED RIFVHKTLLQ KLEVENGIQL CLHMRNFLPG NDIATNIASA IHNSRKTLVI
MSHNFLKSYW CMFEYNMARM ENVYERRDEN VVFLMFYEQM SPRDLPLNVL EMIQSKSYIE
YPNDEYGDTV FWDQLVNALK
//
