ID   M1RB84_MYTGA            Unreviewed;       462 AA.
AC   M1RB84;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=Myeloid differentiation factor 88 b {ECO:0000313|EMBL:AGG10811.1};
OS   Mytilus galloprovincialis (Mediterranean mussel).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC   Autobranchia; Pteriomorphia; Mytilida; Mytiloidea; Mytilidae; Mytilinae;
OC   Mytilus.
OX   NCBI_TaxID=29158 {ECO:0000313|EMBL:AGG10811.1};
RN   [1] {ECO:0000313|EMBL:AGG10811.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23485525; DOI=10.1016/j.dci.2013.02.006;
RA   Toubiana M., Gerdol M., Rosani U., Pallavicini A., Venier P., Roch P.;
RT   "Toll-like receptors and MyD88 adaptors in Mytilus: Complete cds and gene
RT   expression levels.";
RL   Dev. Comp. Immunol. 40:158-166(2013).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   EMBL; KC357781; AGG10811.1; -; mRNA.
DR   AlphaFoldDB; M1RB84; -.
DR   SMR; M1RB84; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070976; F:TIR domain binding; IEA:InterPro.
DR   GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:InterPro.
DR   CDD; cd08312; Death_MyD88; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR034249; MyD88_Death.
DR   InterPro; IPR017281; Myelin_different_resp_MyD88.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR15079; MYD88; 1.
DR   PANTHER; PTHR15079:SF3; MYELOID DIFFERENTIATION PRIMARY RESPONSE PROTEIN MYD88; 1.
DR   Pfam; PF00531; Death; 1.
DR   Pfam; PF13676; TIR_2; 1.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS50017; DEATH_DOMAIN; 1.
DR   PROSITE; PS50104; TIR; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Inflammatory response {ECO:0000256|ARBA:ARBA00023198}.
FT   DOMAIN          61..126
FT                   /note="Death"
FT                   /evidence="ECO:0000259|PROSITE:PS50017"
FT   DOMAIN          178..314
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
FT   REGION          317..358
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          375..462
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        325..358
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        375..428
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   462 AA;  51439 MW;  C9B420495E1BF690 CRC64;
     MSRKMDEDME ILDDTGESLN LDSRLTSIPL DALRRSSRSK IALYLDDQSD IIDEDCGYVT
     DWNGLAELIG FTALEMRKFG RQKSPTQDLL LDWEMTPALN PTLGNLWKYL IELGRLDVLQ
     DCRSFVIKDA ENYILTKERL ANDYLPVQEN SVSQSSAPDH YVDETRMLVT GDIDGSITLF
     DAFVCYNADS TGKDIVFVKD MIKKLEKEYD LKLCVPGRDD LPGGSRYVTD AKLIESRCKR
     MIIVLSHEYL HSSACDFQVK FAHALAPGAR SKKLIPVLIE PSVPIPQILR HVTLCDYTKN
     DLMEWFWDRL AKSVKAPLDP EPNRMGSSVE SSSPMSIPSN SSSSLQSQTS LSPSQSLSSI
     ENYRLTNDSI KNAQRQLSES ASMSSNTSSD SGFHSSSFQS QGASSLQSNQ SSFSNEYTSL
     STESFPTSSS KAREKKKGTN IFGQLKAKVS GKKHNNNTSS QA
//