ID M1RJ59_MYTGA Unreviewed; 848 AA.
AC M1RJ59;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE SubName: Full=Toll-like receptor j {ECO:0000313|EMBL:AGG10807.1};
OS Mytilus galloprovincialis (Mediterranean mussel).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Mytilida; Mytiloidea; Mytilidae; Mytilinae;
OC Mytilus.
OX NCBI_TaxID=29158 {ECO:0000313|EMBL:AGG10807.1};
RN [1] {ECO:0000313|EMBL:AGG10807.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23485525; DOI=10.1016/j.dci.2013.02.006;
RA Toubiana M., Gerdol M., Rosani U., Pallavicini A., Venier P., Roch P.;
RT "Toll-like receptors and MyD88 adaptors in Mytilus: Complete cds and gene
RT expression levels.";
RL Dev. Comp. Immunol. 40:158-166(2013).
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; KC357777; AGG10807.1; -; mRNA.
DR AlphaFoldDB; M1RJ59; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365:SF530; TOLL-9, ISOFORM A; 1.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF01582; TIR; 1.
DR PIRSF; PIRSF037595; Toll-like_receptor; 3.
DR PRINTS; PR01537; INTRLKN1R1F.
DR SMART; SM00369; LRR_TYP; 5.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50104; TIR; 1.
PE 2: Evidence at transcript level;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius}; Receptor {ECO:0000313|EMBL:AGG10807.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..848
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004017599"
FT TRANSMEM 652..677
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 701..845
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 848 AA; 98956 MW; BE586A4506E9D409 CRC64;
MKKTLNLFIL FIIIAVTNGN LKSSCMYERS IQHKLIAHCE NQGFNSVPRN LSRKISELIL
SNNSIRMLQN DSFVHYTKME IMILNKNRIS EIKEDAFVGL HLLKVLKVND NLINITTLSN
GVFRHLSNLI DLDISLNNKP LDANTKFVYP DGAFSTLRSL QNLSIDLFMF PEFGAGFSSL
KNLTALKFSQ CYLRNSSRFR LSNSTFEHFS SNLKELYISG CRNFFLLEYG LLEYFPYLKI
LDFSESYVHL YQALRILHPF QNKNMSVINF HHISDNSINE DDFPYSVVLT AELMTYLRTI
CIEALDLSKT GIVDYQHNSL LSFEHPECFK TFIISANRLP ATTARHSLQL YSFLMKAINI
KVYDLSYLTI DYAHPVFINV YNTESFNHLP KSAKYFQMSP HWNINYSLPS SIEFLRFTHI
QSTPSSASIT CKNTSLKYLD VSYGVYKRYP KFSEDCLKQL EYLDISGISV AIITFPSMLL
PKLVVLKMTN ARIDQIVRKG REWMSFRAPA LREVDISFNY IWTLEETTFF EQPHITHLNM
SNNLFRTIPK FVTKLQKLEY LDLSNNLITS LDDNVMHWLD KMIHLNPILN FDNNAFVCSC
DTLDFLLWFE KTNVTFYNGD NYTCTMSNNK QILLKEVAKN TNKYFADCKA TLWLHVGIIL
VASAFGIFVP LSLLYNYRWN IILYMYRKVR RVVEKNLHAN YLYDAYVSYE ERSVLWIQKC
LLPKIEEEWG LKVCLHDRDL LPGDITADAK AESIQQSRHV VFIITEHFTE GKWGRFEIDR
AKYEKYTTNL RKIIVILQNI RIEDIPDEIV NISNDVCFIE MALDENEIIN STDNQRDWLK
LKALLYLN
//