ID M1VEW4_PLAFA Unreviewed; 1688 AA.
AC M1VEW4;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Merozoite surface protein 1 {ECO:0000256|ARBA:ARBA00022062};
DE AltName: Full=Merozoite surface antigen {ECO:0000256|ARBA:ARBA00031689};
DE AltName: Full=PMMSA {ECO:0000256|ARBA:ARBA00032276};
GN Name=msp1 {ECO:0000313|EMBL:BAM84404.1};
OS Plasmodium falciparum (malaria parasite P. falciparum).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=5833 {ECO:0000313|EMBL:BAM84404.1};
RN [1] {ECO:0000313|EMBL:BAM84404.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tz03-086 {ECO:0000313|EMBL:BAM84404.1};
RA Tanabe K., Mita T., Palacpac N.M.Q., Arisue N., Tougan T., Kawai S.,
RA Jombart T., Kobayashi F., Horii T.;
RT "Within-population genetic diversity of Plasmodium falciparum vaccine
RT candidate antigens reveals geographic distance from a Central sub-Saharan
RT African origin.";
RL Vaccine 31:1134-1139(2013).
CC -!- FUNCTION: By binding to host proinflammatory cytokine S100P may
CC interfere with host immune responses. {ECO:0000256|ARBA:ARBA00043850}.
CC -!- SUBUNIT: Interacts with host SLC4A1/Band 3 (via 5ABC region) on the
CC host erythrocyte surface in a sialic acid-independent manner.
CC {ECO:0000256|ARBA:ARBA00044022}.
CC -!- SUBUNIT: Interacts with host glycophorin GYPA in a sialic acid-
CC independent manner. {ECO:0000256|ARBA:ARBA00044006}.
CC -!- SUBUNIT: Interacts with host proinflammatory cytokine S100P; the
CC interaction blocks S100P inflammatory and chemotactic activities.
CC {ECO:0000256|ARBA:ARBA00044008}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004609};
CC Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}. Membrane
CC {ECO:0000256|ARBA:ARBA00004589}; Lipid-anchor, GPI-anchor
CC {ECO:0000256|ARBA:ARBA00004589}. Vacuole membrane
CC {ECO:0000256|ARBA:ARBA00043950}; Lipid-anchor, GPI-anchor
CC {ECO:0000256|ARBA:ARBA00043950}.
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DR EMBL; AB502452; BAM84404.1; -; Genomic_DNA.
DR VEuPathDB; PlasmoDB:PfKE01_090034700; -.
DR VEuPathDB; PlasmoDB:PfSN01_090034900; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR InterPro; IPR010901; MSP1_C.
DR InterPro; IPR024730; MSP1_EGF_1.
DR Pfam; PF12946; EGF_MSP1_1; 1.
DR Pfam; PF07462; MSP1_C; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Merozoite {ECO:0000313|EMBL:BAM84404.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Vacuole {ECO:0000256|ARBA:ARBA00022554}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1688
FT /note="Merozoite surface protein 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004018915"
FT TRANSMEM 1669..1687
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 949..1504
FT /note="Merozoite surface 1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07462"
FT DOMAIN 1580..1616
FT /note="Merozoite surface protein EGF"
FT /evidence="ECO:0000259|Pfam:PF12946"
FT REGION 68..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 697..733
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 876..923
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1216..1246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1438..1459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 273..300
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 448..493
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 566..593
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 68..107
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 697..716
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 876..919
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1226..1246
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1688 AA; 193030 MW; F3BB418344AE781D CRC64;
MKIIFFLCSF LFFIINTQCV THESYQELVK KLEALEDAVL TGYGLFHKEK MVLKDGANTQ
VVAKPADAVS TQSAKNPPGA TVPSGTASTK GAIRSPGAAN PSDDSSDSDA KSYADLKHRV
QNYLFTIKEL KYPELFDLTN HMLTLCDNIH GFKYLIDGYE EINELLYKLN FYFDLLRAKL
NDVCANDYCQ IPFNLKIRAN ELDVLKKLVF GYRKPLDNIK DNVGKMEDYI KKNKTTIANI
NELIEGSKKT IDQNKNADNE EGKKKLYQAQ YDLSIYNKQL EEAHNLISVL EKRIDTLKKN
ENIKKLLEDI DKIKTDAEKP TTGSKPNTLL DKNKKIEEHE EKIKEIAKTI KFNIDSLFTD
PLELEYYLRE KNKKVDVTPK SQDPTKSVQI PKVPYPNGIV YPLPLTDIHN SLAADNDKNS
YGDLMNPNTK EKINEKIITD NKERKIFINN IKKQIDLEEK NINHTKEQNK KLLEDYEKSK
KDYEELLEKF YEMKFNNNFN KDVVDKMFSA RYTYNVEKQR YNNKFSSSNN SVYNVQKLKK
ALSYLEDYSL RKGISEKDFN HYYTLKTGLE ADIKKLTEEI KSSENKILEK NFKGLTHSAN
ASLEVYDIVK LQVQKVLLIK KIEDLRKIEL FLKNAQLKDS IHVPNIYKPQ NKPEPYYLIV
LKKEVDKLKE FIPKVKDMLK KEQAVLSSIT QPLVAASETT EDGGHSTHTL SQSGETEVTE
ETEETEETVG HTTTVTITLP PKEVKVVENS IEHKSNDNSQ ALTKTVYLKK LDEFLTKSYI
CHKYILVSNS SMDQKLLEVY NLTPEEKNEL KSCDPLDLLF NIQNNIPAMY SLYDSMNNDL
QHLFFELYQK EMIYYLHKLK EENHIKKLLE EQKQITGTSS TSSPGNTTVN TAQSATHSNS
QNQQSNASST NTQNGVAVSS GPAVVEESHD PLTVLSISND LKGIVSLLNL GNKTKVPNPL
TISTTEMEKF YENILKNNDT YFNDDIKQFV KSNSKVITGL TETQKNALND EIKKLKDTLQ
LSFDLYNKYK LKLDRLFNKK KELGQDKMQI KKLTLLKEQL ESKLNSLNNP HNVLQNFSVF
FNKKKEAEIA ETENTLENTK ILLKHYKGLV KYYNGESSPL KTLSEVSIQT EDNYANLEKF
RVLSKIDGKL NDNLHLGKKK LSFLSSGLHH LITELKEVIK NKNYTGNSPS ENNKKVNEAL
KSYENFLPEA KVTTVVTPPQ PDVTPSPLSV RVSGSSGSTK EETQIPTSGS LLTELQQVVQ
LQNYDEEDDS LVVLPIFGES EDNDEYLDQV VTGEAISVTM DNILSGFENE YDVIYLKPLA
GVYRSLKKQI EKNIFTFNLN LNDILNSRLK KRKYFLDVLE SDLMQFKHIS SNEYIIEDSF
KLLNSEQKNT LLKSYKYIKE SVENDIKFAQ EGISYYEKVL AKYKDDLESI KKVIKEEKEK
FPSSPPTTPP SPAKTDEQKK ESKFLPFLTN IETLYNNLVN KIDDYLINLK AKINDCNVEK
DEAHVKITKL SDLKAIDDKI DLFKNTDDFE AIKKLINDDT KKDMLGKLLS TGLVQNFPNT
IISKLIEGKF QDMLNISQHQ CVKKQCPQNS GCFRHLDERE ECKCLLNYKQ EGDKCVENPN
PTCNENNGGC DADAKCTEED SGSNGKKITC ECTKPDSYPF FDGIFCSSSN FLGISFLLIL
MLILYSFI
//
