ID M1VF11_PLAFA Unreviewed; 1702 AA.
AC M1VF11;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Merozoite surface protein 1 {ECO:0000256|ARBA:ARBA00022062};
DE AltName: Full=Merozoite surface antigen {ECO:0000256|ARBA:ARBA00031689};
DE AltName: Full=PMMSA {ECO:0000256|ARBA:ARBA00032276};
GN Name=msp1 {ECO:0000313|EMBL:BAM84484.1};
OS Plasmodium falciparum (malaria parasite P. falciparum).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=5833 {ECO:0000313|EMBL:BAM84484.1};
RN [1] {ECO:0000313|EMBL:BAM84484.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Gha1109-038 {ECO:0000313|EMBL:BAM84484.1};
RA Tanabe K., Mita T., Palacpac N.M.Q., Arisue N., Tougan T., Kawai S.,
RA Jombart T., Kobayashi F., Horii T.;
RT "Within-population genetic diversity of Plasmodium falciparum vaccine
RT candidate antigens reveals geographic distance from a Central sub-Saharan
RT African origin.";
RL Vaccine 31:1134-1139(2013).
CC -!- FUNCTION: By binding to host proinflammatory cytokine S100P may
CC interfere with host immune responses. {ECO:0000256|ARBA:ARBA00043850}.
CC -!- SUBUNIT: Interacts with host SLC4A1/Band 3 (via 5ABC region) on the
CC host erythrocyte surface in a sialic acid-independent manner.
CC {ECO:0000256|ARBA:ARBA00044022}.
CC -!- SUBUNIT: Interacts with host glycophorin GYPA in a sialic acid-
CC independent manner. {ECO:0000256|ARBA:ARBA00044006}.
CC -!- SUBUNIT: Interacts with host proinflammatory cytokine S100P; the
CC interaction blocks S100P inflammatory and chemotactic activities.
CC {ECO:0000256|ARBA:ARBA00044008}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004609};
CC Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}. Membrane
CC {ECO:0000256|ARBA:ARBA00004589}; Lipid-anchor, GPI-anchor
CC {ECO:0000256|ARBA:ARBA00004589}. Vacuole membrane
CC {ECO:0000256|ARBA:ARBA00043950}; Lipid-anchor, GPI-anchor
CC {ECO:0000256|ARBA:ARBA00043950}.
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DR EMBL; AB502532; BAM84484.1; -; Genomic_DNA.
DR VEuPathDB; PlasmoDB:PfML01_090034800; -.
DR VEuPathDB; PlasmoDB:PfSD01_090035300; -.
DR VEuPathDB; PlasmoDB:PfTG01_090034700; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR InterPro; IPR010901; MSP1_C.
DR InterPro; IPR024730; MSP1_EGF_1.
DR Pfam; PF12946; EGF_MSP1_1; 1.
DR Pfam; PF07462; MSP1_C; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Merozoite {ECO:0000313|EMBL:BAM84484.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Vacuole {ECO:0000256|ARBA:ARBA00022554}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1702
FT /note="Merozoite surface protein 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004017986"
FT TRANSMEM 1683..1701
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 963..1518
FT /note="Merozoite surface 1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07462"
FT DOMAIN 1594..1630
FT /note="Merozoite surface protein EGF"
FT /evidence="ECO:0000259|Pfam:PF12946"
FT REGION 63..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 714..747
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 890..937
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1230..1260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1452..1473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 291..318
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 465..510
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 583..610
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 63..121
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 714..733
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 890..933
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1240..1260
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1702 AA; 193935 MW; 6DFD22347E6D86E4 CRC64;
MKIIFFLCSF LFFIINTQCV THESYQELVK KLEALEDAVL TGYSLFQKEK MVLNEEEITT
KGASAQSGAS AQSGASAQSG ASAQSGTSGP SGPSGPSGTS PSSRSNTLPR SNTSSGASPP
ADASDSDAKS YADLKHRVRN YLFTIKELKY PELFDLTNHM LTLCDNIHGF KYLIDGYEEI
NELLYKLNFY FDLLRAKLND VCANDYCQIP FNLKIRANEL DVLKKLVFGY RKPLDNIKDN
VGKMEDYIKK NKTTIANINE LIEGSKKTID QNKNADNEEG KKKLYQAQYD LSIYNKQLEE
AHNLISVLEK RIDTLKKNEN IKKLLDKINE IKNPPPANSG NTPNTLLDKN KKIEEHEEKI
KEIAKTIKFN IDSLFTDPLE LEYYLREKNK KVDVTPKSQD PTKSVQIPKV PYPNGIVYPL
PLTDIHNSLA ADNDKNSYGD LMNPDTKEKI NEKIITDNKE RKIFINNIKK QIDLEEKNIN
HTKEQNKKLL EDYEKSKKDY EELLEKFYEM KFNNNFDKDV VDKIFSARYT YNVEKQRYNN
KFSSSNNSVY NVQKLKKALS YLEDYSLRKG ISEKDFNHYY TLKTGLEADI KKLTEEIKSS
ENKILEKNFK GLTHSANASL EVSDIVKLQV QKVLLIKKIE DLRKIELFLK NAQLKDSIHV
PNIYKPQNKP EPYYLIVLKK EVDKLKEFIP KVKDMLKKEQ AVLSSITQPL VAASETTEDG
GHSTHTLSQS GETEVTEETE ETVGHTTTVT ITLPPKEVKV VENSIEHKSN DNSQALTKTV
YLKKLDEFLT KSYICHKYIL VSNSSMDQKL LEVYNLTPEE KNELKSCDPL DLLFNIQNNI
PAMYSLYDSM NNDLQHLFFE LYQKEMIYYL HKLKEENHIK KLLEEQKQIT GTSSTSSPGN
TTVNTAQSAT HSNSQNQQSN ASSTNTQNGV AVSSGPAVVE ESHDPLTVLS ISNDLKGIVS
LLNLGNKTKV PNPLTISTTE MEKFYENILK NNDTYFNDDI KQFVKSNSKV ITGLTETQKN
ALNDEIKKLK DTLQLSFDLY NKYKLKLDRL FNKKKELGQD KMQIKKLTLL KEQLESKLNS
LNNPHNVLQN FSVFFNKKKE AEIAETENTL ENTKILLKHY KGLVKYYNGE SSPLKTLSEV
SIQTEDNYAN LEKFRVLSKI DGKLNDNLHL GKKKLSFLSS GLHHLITELK EVIKNKNYTG
NSPSENNKKV NEALKSYENF LPEAKVTTVV TPPQPDVTPS PLSVRVSGSS GSTKEETQIP
TSGSLLTELQ QVVQLQNYDE EDDSLVVLPI FGESEDNDEY LDQVVTGEAI SVTMDNILSG
FENEYDVIYL KPLAGVYRSL KKQIEKNIFT FNLNLNDILN SRLKKRKYFL DVLESDLMQF
KHISSNEYII EDSFKLLNSE QKNTLLKSYK YIKESVENDI KFAQEGISYY EKVLAKYKDD
LESIKKVIKE EKEKFPSSPP TTPPSPAKTD EQKKESKFLP FLTNIETLYN NLVNKIDDYL
INLKAKINDC NVEKDEAHVK ITKLSDLKAI DDKIDLFKNH NDFEAIKKLI NDDTKKDMLG
KLLSTGLVQN FPNTIISKLI EGKFQDMLNI SQHQCVKKQC PENSGCFRHL DEREECKCLL
NYKQEGDKCV ENPNPTCNEN NGGCDADAKC TEEDSGSNGK KITCECTKPD SYPLFDGIFC
SSSNFLGISF LLILMLILYS FI
//
