ID M1VF28_PLAFA Unreviewed; 1699 AA.
AC M1VF28;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Merozoite surface protein 1 {ECO:0000256|ARBA:ARBA00022062};
DE AltName: Full=Merozoite surface antigen {ECO:0000256|ARBA:ARBA00031689};
DE AltName: Full=PMMSA {ECO:0000256|ARBA:ARBA00032276};
GN Name=msp1 {ECO:0000313|EMBL:BAM84509.1};
OS Plasmodium falciparum (malaria parasite P. falciparum).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=5833 {ECO:0000313|EMBL:BAM84509.1};
RN [1] {ECO:0000313|EMBL:BAM84509.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=TiMS95-102 {ECO:0000313|EMBL:BAM84509.1};
RA Tanabe K., Mita T., Palacpac N.M.Q., Arisue N., Tougan T., Kawai S.,
RA Jombart T., Kobayashi F., Horii T.;
RT "Within-population genetic diversity of Plasmodium falciparum vaccine
RT candidate antigens reveals geographic distance from a Central sub-Saharan
RT African origin.";
RL Vaccine 31:1134-1139(2013).
RN [2] {ECO:0000313|EMBL:BAN59451.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PFS79 {ECO:0000313|EMBL:BAN59451.1};
RA Tanabe K., Zollner G.E., Sattabongkt J., Khuntirat B., Honma H., Mita T.,
RA Tsuboi T., Coleman R.;
RT "Genetic diversity of Plasmodium falciparum in an isolated village in
RT western Thailand.";
RL Submitted (JUN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: By binding to host proinflammatory cytokine S100P may
CC interfere with host immune responses. {ECO:0000256|ARBA:ARBA00043850}.
CC -!- SUBUNIT: Interacts with host SLC4A1/Band 3 (via 5ABC region) on the
CC host erythrocyte surface in a sialic acid-independent manner.
CC {ECO:0000256|ARBA:ARBA00044022}.
CC -!- SUBUNIT: Interacts with host glycophorin GYPA in a sialic acid-
CC independent manner. {ECO:0000256|ARBA:ARBA00044006}.
CC -!- SUBUNIT: Interacts with host proinflammatory cytokine S100P; the
CC interaction blocks S100P inflammatory and chemotactic activities.
CC {ECO:0000256|ARBA:ARBA00044008}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004609};
CC Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}. Membrane
CC {ECO:0000256|ARBA:ARBA00004589}; Lipid-anchor, GPI-anchor
CC {ECO:0000256|ARBA:ARBA00004589}. Vacuole membrane
CC {ECO:0000256|ARBA:ARBA00043950}; Lipid-anchor, GPI-anchor
CC {ECO:0000256|ARBA:ARBA00043950}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB502557; BAM84509.1; -; Genomic_DNA.
DR EMBL; AB827758; BAN59451.1; -; Genomic_DNA.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR InterPro; IPR010901; MSP1_C.
DR InterPro; IPR024730; MSP1_EGF_1.
DR Pfam; PF12946; EGF_MSP1_1; 1.
DR Pfam; PF07462; MSP1_C; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Merozoite {ECO:0000313|EMBL:BAM84509.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Vacuole {ECO:0000256|ARBA:ARBA00022554}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1699
FT /note="Merozoite surface protein 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007688824"
FT TRANSMEM 1680..1698
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 961..1515
FT /note="Merozoite surface 1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07462"
FT DOMAIN 1591..1627
FT /note="Merozoite surface protein EGF"
FT /evidence="ECO:0000259|Pfam:PF12946"
FT REGION 58..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 82..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 709..745
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 888..935
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1228..1258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1450..1470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 460..505
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 578..605
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 82..121
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 709..728
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 888..931
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1238..1258
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1699 AA; 193460 MW; C926C669CA88A04D CRC64;
MKIIFFLCSF LFFIINTQCV THESYQELVK KLEALEDAVL TGYSLFQKEK MVLNEGTSGT
AVTTSTPGSV ASGGSVASGG SGGSVASGGS GGSVASGGSV ASGGSGNSRR TNPSDNSSDS
DAKSYADLKH RVRNYLFTIK ELKYPELFDL TNHMLTLCDN IHGFKYLIDG YEEINELLYK
LNFYFDLLRA KLNDVCANDY CQIPFNLKIR ANELDVLKKI VFGYRKPLDN IKDNVGKMED
YIKKNKTTIA NINELIEGSK KTIDQNKNAD NEEGKKKLYQ AQYDLFIYNK QLQEAHNLIS
VLEKRIDTLK KNENIKKLLE DIDKIKTDAE KLTTGSKPNT LLDKNKKIEE HEEKIKEIAK
TIKFNIDSLF TDPLELEYYL REKNKKVDVT PKSQDPTKSV QIPKVPYPNG IVYPLPLTDI
HNSLAADNDK NSYGDLMNPD TKEKINEKII TDNKERKIFI NNIKKQIDLE EKNINHTKEQ
NKKLLEDYEK SKKDYEELLE KFYEMKFNNN FDKDVVDKIF RARYTYNVEK QTYNNKFSSS
NNSVYNVQKL KKALSYLEDY SLRKGISEKD FNHYYTLKTG LEADIKKLTE EIKSSENKIL
EKNFKGLTHS ANASLEVSDI VKLQVQKVLL IKKIEDLRKI ELFLKNAQLK DSIHVPNIYK
PQNKPEPYYL IVLKKEVDKL KEFIPKVKDM LKKEQAVLSS ITQPLVAASE TTEDGGHSTH
TLSQSGETEV TEETEETEET VGHTTTVTIT LPPKEVKVVE NSIEHKSNDN SQALTKTVYL
KKLDEFLTKS YICHKYILVS NSSMDQKLLE VYNLTPEEEN ELKSCDPLDL LFNIQNNIPA
MYSLYDSMNN DLQHLFFELY QKEMIYYLHK LKEENHIKKL LEEQKQITGT SSTSSPGNTT
VNTAQSATHS NSQNQQSNAS STNTQNGVAV SSGPAVVEES HDPLTVLSIS NDLKGIVSLL
NLGNKTKVPN PLTISTTEME KFYENILKNN DTYFNDDIKQ FVKSNSKVIT GLTETQKNAL
NDEIKKLKDT LQLSFDLYNK YKLKLDRLFN KKKELGQDKM QIKKLTLLKE QLESKLNSLN
NPHNVLQNFS VFFNKKKEAE IAETENTLEN TKILLKHYKG LVKYYNGESS PLKTLSEVSI
QTEDNYANLE KFRTLSKIDG KLNDNLHLGK KKLSFLSSGL HHLITELKEV IKNKNYTGNS
PSENNKKVNE ALKSYENFLP EAKVTTVVTP PQPDVTPSPL SVRVSGSSGS TKEETQIPTS
GSLLTELQQV VQLQNYDEED DSLVVLPIFG ESEDNDEYLD QVVTGEAISV TMDNILSGFE
NEYDVIYLKP LAGVYRSLKK QIEKNIFTFN LNLNDILNSR LKKRKYFLDV LESDLMQFKH
ISSNEYIIED SFKLLNSEQK NTLLKSYKYI KESVENDIKF AQEGISYYEK VLAKYKDDLE
SIKKVIKEEK EFPSSPPTTP PSPAKTDEQK KESKFLPFLT NIETLYNNLV NKIDDYLINL
KAKINDCNVE KDEAHVKITK LSDLKAIDDK IDLFKNTNDF EAIKKLINDD TKKDMLGKLL
STGLVQNFPN TIISKLIEGK FQDMLNISQH QCVKKQCPEN SGCFRHLDER EECKCLLNYK
QEGDKCVENP NPTCNENNGG CDADATCTEE DSGSSRKKIT CECTKPDSYP LFDGIFCSSS
NFLGISFLLI LMLILYSFI
//
