ID M1VHA3_CYAM1 Unreviewed; 415 AA.
AC M1VHA3;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Probable gamma hydroxybutyrate dehydrogenase {ECO:0000313|EMBL:BAM80223.1};
GN ORFNames=CYME_CMJ086C {ECO:0000313|EMBL:BAM80223.1};
OS Cyanidioschyzon merolae (strain NIES-3377 / 10D) (Unicellular red alga).
OC Eukaryota; Rhodophyta; Bangiophyceae; Cyanidiales; Cyanidiaceae;
OC Cyanidioschyzon.
OX NCBI_TaxID=280699 {ECO:0000313|EMBL:BAM80223.1, ECO:0000313|Proteomes:UP000007014};
RN [1] {ECO:0000313|EMBL:BAM80223.1, ECO:0000313|Proteomes:UP000007014}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=10D {ECO:0000313|EMBL:BAM80223.1,
RC ECO:0000313|Proteomes:UP000007014};
RX PubMed=15071595; DOI=10.1038/nature02398;
RA Matsuzaki M., Misumi O., Shin-i T., Maruyama S., Takahara M.,
RA Miyagishima S., Mori T., Nishida K., Yagisawa F., Nishida K., Yoshida Y.,
RA Nishimura Y., Nakao S., Kobayashi T., Momoyama Y., Higashiyama T.,
RA Minoda A., Sano M., Nomoto H., Oishi K., Hayashi H., Ohta F., Nishizaka S.,
RA Haga S., Miura S., Morishita T., Kabeya Y., Terasawa K., Suzuki Y.,
RA Ishii Y., Asakawa S., Takano H., Ohta N., Kuroiwa H., Tanaka K.,
RA Shimizu N., Sugano S., Sato N., Nozaki H., Ogasawara N., Kohara Y.,
RA Kuroiwa T.;
RT "Genome sequence of the ultrasmall unicellular red alga Cyanidioschyzon
RT merolae 10D.";
RL Nature 428:653-657(2004).
RN [2] {ECO:0000313|EMBL:BAM80223.1, ECO:0000313|Proteomes:UP000007014}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=10D {ECO:0000313|EMBL:BAM80223.1,
RC ECO:0000313|Proteomes:UP000007014};
RX PubMed=17623057; DOI=10.1186/1741-7007-5-28;
RA Nozaki H., Takano H., Misumi O., Terasawa K., Matsuzaki M., Maruyama S.,
RA Nishida K., Yagisawa F., Yoshida Y., Fujiwara T., Takio S., Tamura K.,
RA Chung S.J., Nakamura S., Kuroiwa H., Tanaka K., Sato N., Kuroiwa T.;
RT "A 100%-complete sequence reveals unusually simple genomic features in the
RT hot-spring red alga Cyanidioschyzon merolae.";
RL BMC Biol. 5:28-28(2007).
CC -!- SIMILARITY: Belongs to the HIBADH-related family. NP60 subfamily.
CC {ECO:0000256|ARBA:ARBA00007598}.
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DR EMBL; AP006492; BAM80223.1; -; Genomic_DNA.
DR RefSeq; XP_005534830.1; XM_005534773.1.
DR AlphaFoldDB; M1VHA3; -.
DR STRING; 280699.M1VHA3; -.
DR EnsemblPlants; CMJ086CT; CMJ086CT; CMJ086C.
DR GeneID; 16994171; -.
DR Gramene; CMJ086CT; CMJ086CT; CMJ086C.
DR KEGG; cme:CYME_CMJ086C; -.
DR eggNOG; KOG0409; Eukaryota.
DR HOGENOM; CLU_035117_0_0_1; -.
DR OMA; NALGCEY; -.
DR OrthoDB; 203032at2759; -.
DR Proteomes; UP000007014; Chromosome 10.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43580; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR PANTHER; PTHR43580:SF2; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007014}.
FT DOMAIN 105..279
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 286..405
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
SQ SEQUENCE 415 AA; 44877 MW; A26CF64440B8D30F CRC64;
MPRMCSESGA LFRAPTAFAT PCALNSVQRP SRQLRSKVTD DSNWPPQKAW VSAHRLPRFS
WRRRFERPLA GTQSPRTLHN SLELTACMHG EASAPDRKGA TMSAVGFIGL GIMGSGMARN
LFRAGHSLYV WNRTRSAAEA FAKELVNEQC GESKGYSSGN AQVHVADSPR SVAGACNVIY
SMLSTPEAAL SVHLDAERGT VQELGPQKML IECSTLDVST MERLSEAVHQ RGALFLEAPV
SGSKVPAQTG TLIFLCSGDR AAYDRVASSG LDVMGKASFF LGERCGVGTK MKIVVNMIMG
SMMVALAEGA SLAESCGLST ETLNEILGLG AMNSPLFSMK LPNMISSQYE AHFPLKHQQK
DLRFAISLGD EMEQWLPLSA IANEVFKAAQ ASGFGDYDFS AVVEALRNKK RRPSN
//
