ID M1VNZ8_PLAFA Unreviewed; 1724 AA.
AC M1VNZ8;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Merozoite surface protein 1 {ECO:0000256|ARBA:ARBA00022062};
DE AltName: Full=Merozoite surface antigen {ECO:0000256|ARBA:ARBA00031689};
DE AltName: Full=PMMSA {ECO:0000256|ARBA:ARBA00032276};
GN Name=msp1 {ECO:0000313|EMBL:BAM84408.1};
OS Plasmodium falciparum (malaria parasite P. falciparum).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=5833 {ECO:0000313|EMBL:BAM84408.1};
RN [1] {ECO:0000313|EMBL:BAM84408.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tz98-009 {ECO:0000313|EMBL:BAM84408.1};
RA Tanabe K., Mita T., Palacpac N.M.Q., Arisue N., Tougan T., Kawai S.,
RA Jombart T., Kobayashi F., Horii T.;
RT "Within-population genetic diversity of Plasmodium falciparum vaccine
RT candidate antigens reveals geographic distance from a Central sub-Saharan
RT African origin.";
RL Vaccine 31:1134-1139(2013).
CC -!- FUNCTION: By binding to host proinflammatory cytokine S100P may
CC interfere with host immune responses. {ECO:0000256|ARBA:ARBA00043850}.
CC -!- SUBUNIT: Interacts with host SLC4A1/Band 3 (via 5ABC region) on the
CC host erythrocyte surface in a sialic acid-independent manner.
CC {ECO:0000256|ARBA:ARBA00044022}.
CC -!- SUBUNIT: Interacts with host glycophorin GYPA in a sialic acid-
CC independent manner. {ECO:0000256|ARBA:ARBA00044006}.
CC -!- SUBUNIT: Interacts with host proinflammatory cytokine S100P; the
CC interaction blocks S100P inflammatory and chemotactic activities.
CC {ECO:0000256|ARBA:ARBA00044008}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004609};
CC Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}. Membrane
CC {ECO:0000256|ARBA:ARBA00004589}; Lipid-anchor, GPI-anchor
CC {ECO:0000256|ARBA:ARBA00004589}. Vacuole membrane
CC {ECO:0000256|ARBA:ARBA00043950}; Lipid-anchor, GPI-anchor
CC {ECO:0000256|ARBA:ARBA00043950}.
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DR EMBL; AB502456; BAM84408.1; -; Genomic_DNA.
DR VEuPathDB; PlasmoDB:PfGA01_090034600; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR InterPro; IPR010901; MSP1_C.
DR InterPro; IPR024730; MSP1_EGF_1.
DR Pfam; PF12946; EGF_MSP1_1; 1.
DR Pfam; PF07462; MSP1_C; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Merozoite {ECO:0000313|EMBL:BAM84408.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Vacuole {ECO:0000256|ARBA:ARBA00022554}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1724
FT /note="Merozoite surface protein 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004019091"
FT TRANSMEM 1705..1723
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 985..1540
FT /note="Merozoite surface 1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07462"
FT DOMAIN 1616..1652
FT /note="Merozoite surface protein EGF"
FT /evidence="ECO:0000259|Pfam:PF12946"
FT REGION 61..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 727..779
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 912..959
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1252..1282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1474..1495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 303..330
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 478..523
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 596..623
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 61..133
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 727..746
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 912..955
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1262..1282
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1724 AA; 196038 MW; 08519CCF1C6F795C CRC64;
MKIIFFLCSF LFFIINTQCV THESYQELVK KLEALEDAVL TGYGLFHKEK MILNEEEITT
KGASAQSGTS GTSGTSGTSG TSGTSGTSGT SGTSGTSGTS GTSGPSGPSG TSPSSRSNTL
PRSNTSSGAS PPADASDSDA KSYADLKHRV RNYLFTIKEL KYPELFDLTN HMLTLCDNIH
GFKYLIDGYE EINELLYKLN FYFDLLRAKL NDVCANDYCQ IPFNLKIRAN ELDVLKKLVF
GYRKPLDNIK DNVGKMEDYI KKNKTTIANI NELIEGSKKT IDQNKNADNE EGKKKLYQAQ
YDLSIYNKQL EEAHNLISVL EKRIDTLKKN ENIKKLLEDI DKIKTDAEKL TTGSKPNTLL
DKNKKIEEHE EKIKEIAKTI KFNIDSLFTD PLELEYYLRE KNKKVDVTPK SQDPTKSVQI
PKVPYPNGIV YPLPLTDIHN SLAADNDKNS YGDLMNPGTK EKINEKIITD NKERKIFINN
IKKQIDLEEK NINHTKEQNK KLLEDYEKSK KDYEELLEKF YEMKFNNNFD KDVVDKMFSA
RYTYNVEKQR YNNKFSSSNN SVYNVQKLKK ALSYLEDYSL RKGISEKDFN HYYTLKTGLE
ADIKKLTEEI KSSENKILEK NFKGLTHSAN ASLEVYDIVK LQVQKVLLIK KIEDLRKIEL
FLKNAQLKDS IHVPNIYKPQ NKPEPYYLIV LKKEVDKLKE FIPKVKDMLK KEQAVLSSIT
QPLVAASETT EDGGHSTHTL SQSGETEVTE ETEETEETVG HTTTVTITLP PTQPSPPKEV
KVVENSIEHK SNDNSQALTK TVYLKKLDEF LTKSYICHKY ILVSNSSMDQ KLLEVYNLTP
EEKNELKSCD PLDLLFNIQN NIPAMYSLYD SMNNDLQHLF FELYQKEMIY YLHKLKEENH
IKKLLEEQKQ ITGTSSTSSP GNTTVNTAQS ATHSNSQNQQ SNASSTNTQN GVAVSSGPAV
VEESHDPLTV LSISNDLKGI VSLLNLGNKT KVPNPLTIST TEMEKFYENI LKNNDTYFND
DIKQFVKSNS KVITGLTETQ KNALNDEIKK LKDTLQLSFD LYNKYKLKLD RLFNKKKELG
QDKMQIKKLT LLKEQLESKL NSLNNPHNVL QNFSVFFNKK KEAEIAETEN TLENTKILLK
HYKGLVKYYN GESSPLKTLS EVSIQTEDNY ANLEKFRVLS KIDGKLNDNL HLGKKKLSFL
SSGLHHLITE LKEVIKNKNY TGNSPSENNK KVNEALKSYE NFLPEAKVTT VVTPPQPDVT
PSPLSVRVSG SSGSTKEETQ IPTSGSLLTE LQQVVQSQNY DEEDDSLVVL PIFGESEDND
EYLDQVVTGE AISVTMDNIL SGFENEYDVI YLKPLAGVYR SLKKQIEKNI FTFNLNLNDI
LNSRLKKRKY FLDVLESDLM QFKHISSNEY IIEDSFKLLN SEQKNTLLKS YKYIKESVEN
DIKFAQEGIS YYEKVLAKYK DDLESIKKVI KEEKEKFPSS PPTTPPSPAK TDEQKKESKF
LPFLTNIETL YNNLVNKIDD YLINLKAKIN DCNVEKNEAH VKITKLSDLK AIDDKIDLFK
NHNDFEAIKK LINDDTKKDM LGKLLSTGLV QNFPNTIISK LIEGKFQDML NISQHQCVKK
QCPQNSGCFR HLDEREECKC LLNYKQEGDK CVENPNPTCN ENNGGCDADA KCTEEDSGSN
GKKITCECTK PDSYPLFDGI FCSSSNFLGI SFLLILMLIL YSFI
//
